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Identification of serpins specific for activated protein C using a lysate-based screening assay.
Activated protein C (APC) is a powerful anticoagulant enzyme that proteolytically inactivates the cofactors of the Xase and prothrombinase complexes, factors VIIIa and Va. A common mutation in factor V, fVLeiden, confers...
Early (n170/m170) face-sensitivity despite right lateral occipital brain damage in acquired prosopagnosia.
Compared to objects, pictures of faces elicit a larger early electromagnetic response at occipito-temporal sites on the human scalp, with an onset of 130 ms and a peak at about 170 ms. This N170 face effect is larger in the...
Rapid Isolation of Rare Isotype-Switched Hybridoma Variants
Stéphanie Charrin, Roberta Palmulli, Martine Billard, Denis Clay, Claude Boucheix, Guillaume Van Niel, Eric Rubinstein
Jul 04, 2020
CD63, a member of the tetraspanin superfamily, is used as a marker of late endosomes and lysosome-related organelles, as well as a marker of exosomes. Here, we selected rare isotype variants of TS63 by sorting hybridoma cells on...
Targeting activated protein C to treat hemophilia.
PURPOSE OF REVIEW: Hemophilia is a debilitating disease, marked by frequent, painful bleeding events, joint deterioration and early death. All current treatments consist of i.v. infusions of replacement factor or other...
Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury
Stéphanie Debette, Sabrina Schilling, Marie-Gabrielle Duperron, Susanna C Larsson, Hugh S Markus
Aug 02, 2019
IMPORTANCE: Covert vascular brain injury (VBI) is highly prevalent in community-dwelling older persons, but its clinical and therapeutic implications are debated. OBJECTIVE: To better understand the clinical significance of VBI...
Impairment in karrikin but not strigolactone sensing enhances root skewing in Arabidopsis thaliana.
Stéphanie M Swarbreck, Yannick Guerringue, Elsa Matthus, Fiona JC Jamieson, Julia M Davies
Oct 23, 2019
Roots form highly complex systems varying in growth direction and branching pattern to forage for nutrients efficiently. Here mutations in the KAI2 (KARRIKIN INSENSITIVE) α/β-fold hydrolase and the MAX2 (MORE AXILLARY GROWTH 2)...
Arabidopsis thaliana karrikin ROOT skewing Strigolactone waving 4-Butyrolactone Arabidopsis Arabidopsis Proteins Carrier Proteins Furans Gene Expression Regulation Plant Hydrolases Intracellular Signaling Peptides and Proteins Lactones Mutation Phenotype Plant Growth Regulators Plant Roots Pyrans Signal Transduction Transcriptome
A Roadmap for Lowering Crop Nitrogen Requirement.
Stéphanie M Swarbreck, Meng Wang, Yuan Wang, Daniel Kindred, Roger Sylvester-Bradley, Weiming Shi, Varinderpal-Singh, Alison R Bentley, Howard Griffiths
Jun 24, 2019
Increasing nitrogen fertilizer applications have sustained a growing world population in the 20th century. However, to avoid any further associated environmental damage, new sustainable agronomic practices together with new...
BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation.
Nicolas Jardin, François Giudicelli, Daniel Ten Martín, Anaïs Vitrac, Stéphanie De Gois, Rachel Allison, Corinne Houart, Evan Reid, Jamilé Hazan, Coralie Fassier
Nov 01, 2018
Axon navigation BMP signalling hereditary spastic paraplegia Neuropilin 1 Spastin Zebrafish Animals Axons Bone Morphogenetic Proteins COS Cells CRISPR-Cas Systems Cell Line Cell Movement Chlorocebus aethiops GTP-Binding Proteins Gene Knockout Techniques Humans Membrane Proteins Motor Neurons Neuropilin-1 Protein Isoforms Spastic Paraplegia Hereditary Spastin Zebrafish Zebrafish Proteins
Over-expression of TaDWF4 increases wheat productivity under low and sufficient nitrogen through enhanced carbon assimilation.
Matthew J Milner, Stéphanie M Swarbreck, Melanie Craze, Sarah Bowden, Howard Griffiths, Alison R Bentley, Emma J Wallington
Mar 03, 2022
There is a strong pressure to reduce nitrogen (N) fertilizer inputs while maintaining or increasing current cereal crop yields. We show that overexpression of TaDWF4-B, the dominant shoot expressed homoeologue of OsDWF4, in...
Trade-offs in the genetic control of functional and nutritional quality traits in UK winter wheat.
A complex network of trade-offs exists between wheat quality and nutritional traits. We investigated the correlated relationships among several milling and baking traits as well as mineral density in refined white and whole...
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape.
Lenka Veselovska, Sebastien A Smallwood, Heba Saadeh, Kathleen R Stewart, Felix Krueger, Stéphanie Maupetit-Méhouas, Philippe Arnaud, Shin-Ichi Tomizawa, Simon Andrews, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Previously, a role was demonstrated for transcription in the acquisition of DNA methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome by whole genome approaches revealed that the...
Animals Cell Cycle Proteins Chromatin Assembly and Disassembly CpG Islands DNA Methylation DNA Transposable Elements Female Gene Expression Profiling Genes Tumor Suppressor Genomic Imprinting High-Throughput Nucleotide Sequencing Mice Mice Transgenic Oocytes Sequence Analysis RNA Transcription Factors Transcription Initiation Site Transcriptome
Phosphate Deprivation Can Impair Mechano-Stimulated Cytosolic Free Calcium Elevation in Arabidopsis Roots.
Elsa Matthus, Nicholas H Doddrell, Gaëtan Guillaume, Amirah B Mohammad-Sidik, Katie A Wilkins, Stéphanie M Swarbreck, Julia M Davies
Dec 04, 2020
The root tip responds to mechanical stimulation with a transient increase in cytosolic free calcium as a possible second messenger. Although the root tip will grow through a heterogeneous soil nutrient supply, little is known of...
Over-expression of TaDWF4 increases wheat productivity under low and sufficient nitrogen through enhanced carbon assimilation.
Matthew J Milner, Stéphanie M Swarbreck, Melanie Craze, Sarah Bowden, Howard Griffiths, Alison R Bentley, Emma J Wallington
Apr 03, 2022
There is a strong pressure to reduce nitrogen (N) fertilizer inputs while maintaining or increasing current cereal crop yields. We show that overexpression of TaDWF4-B, the dominant shoot expressed homoeologue of OsDWF4, in...
Carbon flux through photosynthesis and central carbon metabolism show distinct patterns between algae, C 3 and C 4 plants
Haim Treves, Anika Küken, Stéphanie Arrivault, Hirofumi Ishihara, Ines Hoppe, Alexander Erban, Melanie Höhne, Thiago Alexandre Moraes, Joachim Kopka, Jedrzej Szymanski, Zoran Nikoloski, Mark Stitt
Jan 28, 2022
Abstract: Photosynthesis-related pathways are regarded as a promising avenue for crop improvement. Whilst empirical studies have shown that photosynthetic efficiency is higher in microalgae than in C3 or C4 crops, the underlying...
Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils
Ellen Hubin, Stéphanie Deroo, Gabriele Kaminksi Schierle, Clemens Kaminski, Louise Serpell, Vinod Subramaniam, Nico van Nuland, Kerensa Broersen, Vincent Raussens, Rabia Sarroukh
Feb 12, 2020
Most Alzheimer's disease (AD) cases are late-onset and characterized by the aggregation and deposition of the amyloid-beta (Aβ) peptide in extracellular plaques in the brain. However, a few rare and hereditary Aβ mutations, such...
Step-by-step protocol for the isolation and transient transformation of hornwort protoplasts.
Anna Neubauer, Stéphanie Ruaud, Manuel Waller, Eftychios Frangedakis, Fay-Wei Li, Svenja I Nötzold, Susann Wicke, Aurélien Bailly, Péter Szövényi
Jun 07, 2022
PREMISE: A detailed protocol for the protoplast transformation of hornwort tissue is not yet available, limiting molecular biological investigations of these plants and comparative analyses with other bryophytes, which display a...
Mechanochemical Polarization of Contiguous Cell Walls Shapes Plant Pavement Cells.
Mateusz Majda, Peter Grones, Ida-Maria Sintorn, Thomas Vain, Pascale Milani, Pawel Krupinski, Beata Zagórska-Marek, Corrado Viotti, Henrik Jönsson, Ewa J Mellerowicz, Olivier Hamant, Stéphanie Robert
Jan 31, 2018
The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has...
A Partial C4 Photosynthetic Biochemical Pathway in Rice.
HsiangChun Lin, Stéphanie Arrivault, Robert A Coe, Shanta Karki, Sarah Covshoff, Efren Bagunu, John E Lunn, Mark Stitt, Robert T Furbank, Julian M Hibberd, William Paul Quick
Oct 29, 2020
Introduction of a C4 photosynthetic pathway into C3 rice (Oryza sativa) requires installation of a biochemical pump that concentrates CO2 at the site of carboxylation in modified bundle sheath cells. To investigate the...
Phosphate Starvation Alters Abiotic-Stress-Induced Cytosolic Free Calcium Increases in Roots.
Elsa Matthus, Katie A Wilkins, Stéphanie M Swarbreck, Nicholas H Doddrell, Fabrizio G Doccula, Alex Costa, Julia M Davies
Feb 08, 2019
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement
Jan Kotál, Stéphanie G. I. Polderdijk, Helena Langhansová, Monika Ederová, Larissa A. Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A. Huntington, Jindřich Chmelař
Sep 02, 2021
Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne...
AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data.
Carlos P Roca, Oliver T Burton, Václav Gergelits, Teresa Prezzemolo, Carly E Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stéphanie Humblet-Baron, Adrian Liston
Jul 09, 2021
Compensating in flow cytometry is an unavoidable challenge in the data analysis of fluorescence-based flow cytometry. Even the advent of spectral cytometry cannot circumvent the spillover problem, with spectral unmixing an...
Carbon flux through photosynthesis and central carbon metabolism show distinct patterns between algae, C3 and C4 plants.
Haim Treves, Anika Küken, Stéphanie Arrivault, Hirofumi Ishihara, Ines Hoppe, Alexander Erban, Melanie Höhne, Thiago Alexandre Moraes, Joachim Kopka, Jedrzej Szymanski, Zoran Nikoloski, Mark Stitt
Jan 28, 2022
Photosynthesis-related pathways are regarded as a promising avenue for crop improvement. Whilst empirical studies have shown that photosynthetic efficiency is higher in microalgae than in C3 or C4 crops, the underlying reasons...
Dominant ACO2 mutations are a frequent cause of isolated optic atrophy.
Majida Charif, Naïg Gueguen, Marc Ferré, Zouhair Elkarhat, Salim Khiati, Morgane LeMao, Arnaud Chevrollier, Valerie Desquiret-Dumas, David Goudenège, Céline Bris, Selma Kane, Jennifer Alban, Stéphanie Chupin, Céline Wetterwald, Leonardo Caporali, Francesca Tagliavini, Chiara LaMorgia, Michele Carbonelli, Neringa Jurkute, Abdelhamid Barakat, Philippe Gohier, Christophe Verny, Magalie Barth, Vincent Procaccio, Dominique Bonneau, Xavier Zanlonghi, Isabelle Meunier, Nicole Weisschuh, Simone Schimpf-Linzenbold, Felix Tonagel, Ulrich Kellner, Patrick Yu-Wai-Man, Valerio Carelli, Bernd Wissinger, Patrizia Amati-Bonneau, Pascal Reynier, European ION Group, Guy Lenaers
Jul 02, 2021
Biallelic mutations in ACO2, encoding the mitochondrial aconitase 2, have been identified in individuals with neurodegenerative syndromes, including infantile cerebellar retinal degeneration and recessive optic neuropathies...
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