The aggregation of β-amyloid (Aβ) into toxic oligomers is a hallmark of Alzheimer’s disease pathology. Here we present a novel approach for the development of peptides capable of preventing amyloid aggregation based upon the...
Level sets have been widely used to isolate features of breast tumors in ultrasound images. However, region-based methods always produce multiple contours. Since tumors are regularly undefined from the shadows and muscular...
Leaves comprise multiple cell types but our knowledge of the patterns of gene expression that underpin their functional specialization is fragmentary. Our understanding and ability to undertake the rational redesign of these...
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3....
The aggregation of β-amyloid (Aβ) into toxic oligomers is a hallmark of Alzheimer’s disease pathology. Here we present a novel approach for the development of peptides capable of preventing amyloid aggregation based upon the...
BACKGROUND: The progressive myoclonic epilepsies (PME) are a heterogeneous group of disorders in which a specific diagnosis cannot be made in a subset of patients, despite exhaustive investigation. C9orf72 repeat expansions are...
The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified...
Late Pliocene and Early Pleistocene epochs 3.6 to 0.8 million years ago1 had climates resembling those forecasted under future warming2. Palaeoclimatic records show strong polar amplification with mean annual temperatures of...
Abstract: The semiconductor tracker (SCT) is one of the tracking systems for charged particles in the ATLAS detector. It consists of 4088 silicon strip sensor modules. During Run 2 (2015–2018) the Large Hadron Collider delivered...
Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable...
A search for the narrow structure, X(5568), reported by the D0 Collaboration in the decay sequence X→B_{s}^{0}π^{±}, B_{s}^{0}→J/ψϕ, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the...
Abstract: A search for direct pair production of scalar partners of the top quark (top squarks or scalar third-generation up-type leptoquarks) in the all-hadronic tt¯ plus missing transverse momentum final state is presented....
Abstract: The inclusive top quark pair (tt¯) production cross-section σtt¯ has been measured in proton–proton collisions at s=13TeV, using 36.1 fb-1 of data collected in 2015–2016 by the ATLAS experiment at the LHC. Using events...
Abstract: The problems of neutrino masses, matter-antimatter asymmetry, and dark matter could be successfully addressed by postulating right-handed neutrinos with Majorana masses below the electroweak scale. In this work...
Abstract: A search for new physics with non-resonant signals in dielectron and dimuon final states in the mass range above 2 TeV is presented. This is the first search for non-resonant signals in dilepton final states at the LHC...
Abstract: The production cross-sections for W± and Z bosons are measured using ATLAS data corresponding to an integrated luminosity of 4.0 pb-1 collected at a centre-of-mass energy s=2.76 TeV. The decay channels W→ℓν and Z→ℓℓ...
Abstract: This paper describes precision measurements of the transverse momentum pTℓℓ (ℓ=e, μ) and of the angular variable ϕη∗ distributions of Drell–Yan lepton pairs in a mass range of 66–116 GeV. The analysis uses data from...