The aggregation of β-amyloid (Aβ) into toxic oligomers is a hallmark of Alzheimer’s disease pathology. Here we present a novel approach for the development of peptides capable of preventing amyloid aggregation based upon the...
Leaves comprise multiple cell types but our knowledge of the patterns of gene expression that underpin their functional specialization is fragmentary. Our understanding and ability to undertake the rational redesign of these...
Level sets have been widely used to isolate features of breast tumors in ultrasound images. However, region-based methods always produce multiple contours. Since tumors are regularly undefined from the shadows and muscular...
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3....
The aggregation of β-amyloid (Aβ) into toxic oligomers is a hallmark of Alzheimer’s disease pathology. Here we present a novel approach for the development of peptides capable of preventing amyloid aggregation based upon the...
BACKGROUND: The progressive myoclonic epilepsies (PME) are a heterogeneous group of disorders in which a specific diagnosis cannot be made in a subset of patients, despite exhaustive investigation. C9orf72 repeat expansions are...
The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified...
Late Pliocene and Early Pleistocene epochs 3.6 to 0.8 million years ago1 had climates resembling those forecasted under future warming2. Palaeoclimatic records show strong polar amplification with mean annual temperatures of...
Abstract: The semiconductor tracker (SCT) is one of the tracking systems for charged particles in the ATLAS detector. It consists of 4088 silicon strip sensor modules. During Run 2 (2015–2018) the Large Hadron Collider delivered...
Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable...
Abstract: A search for heavy resonances decaying into a pair of Z bosons leading to ℓ+ℓ-ℓ′+ℓ′- and ℓ+ℓ-νν¯ final states, where ℓ stands for either an electron or a muon, is presented. The search uses proton–proton collision data...
Abstract: Differential cross-sections are measured for top-quark pair production in the all-hadronic decay mode, using proton-proton collision events collected by the ATLAS experiment in which all six decay jets are separately...
Abstract: A search for new phenomena with top quark pairs in final states with one isolated electron or muon, multiple jets, and large missing transverse momentum is performed. Signal regions are designed to search for two-...
Abstract: A search for new-physics resonances decaying into a lepton and a jet performed by the ATLAS experiment is presented. Scalar leptoquarks pair-produced in pp collisions at s = 13 TeV at the Large Hadron Collider are...
Abstract: A search for a chargino-neutralino pair decaying via the 125 GeV Higgs boson into photons is presented. The study is based on the data collected between 2015 and 2018 with the ATLAS detector at the LHC, corresponding...
Abstract: Higgs boson properties are studied in the four-lepton decay channel (where lepton = e, μ) using 139 fb-1 of proton–proton collision data recorded at s=13 TeV by the ATLAS experiment at the Large Hadron Collider. The...
Abstract: The problems of neutrino masses, matter-antimatter asymmetry, and dark matter could be successfully addressed by postulating right-handed neutrinos with Majorana masses below the electroweak scale. In this work...