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News Media and the Emotional Public Sphere
This article examines the individual, collective, and social emotions embedded in media discussions of the financial crisis. Emotional experiences toward crises and the political institutions associated with them serve as...
News Media and the Emotional Public Sphere
This article examines the individual, collective, and social emotions embedded in media discussions of the financial crisis. Emotional experiences toward crises and the political institutions associated with them serve as...
The effects of dam-reservoir interaction on the nonlinear seismic response of earth dams
The objective of this study is to investigate the effects of dam–reservoir interaction (DRI) on the nonlinear seismic response of earth dams. Although DRI effects have for long been considered as insignificant for earth dams...
Earth dam Reservoir dam-reservoir interaction Dynamic analysis earthquake Finite elements /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/1900/1909 name=Geotechnical Engineering and Engineering Geology
The effects of dam-reservoir interaction on the nonlinear seismic response of earth dams
The objective of this study is to investigate the effects of dam–reservoir interaction (DRI) on the nonlinear seismic response of earth dams. Although DRI effects have for long been considered as insignificant for earth dams...
Earth dam Reservoir dam-reservoir interaction Dynamic analysis earthquake Finite elements /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/1900/1909 name=Geotechnical Engineering and Engineering Geology
Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease.
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher Jh Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Jan 04, 2022
The most frequent missense mutations in familial Parkinson's disease (PD) occur in the highly conserved LRRK2/PARK8 gene with G2019S mutation. We previously established a fly model of PD carrying the LRRK2-G2019S mutation that...
BMP/Mad D. melanogaster Gastrodia elata Blume Lrrk2 NRF2 Parkinson's Disease Glia MOUSE neuroscience Animals Benzyl Alcohols Butyrates Disease Models Animal Dopaminergic Neurons Drosophila melanogaster Gastrodia Glucosides Locomotion Mice NF-E2-Related Factor 2 Neuroglia Neuroprotection Neuroprotective Agents Parkinson Disease Plant Extracts Signal Transduction
Multi-frequency, multi-sonar mapping of shallow habitats – Efficacy and management implications in the National Marine Park of Zakynthos, Greece
Elias Fakiris, Philippe Blondel, George Papatheodorou, Dimitris Christodoulou, Xenophon Dimas, Nikos Georgiou, Stavroula Kordella, Dimitriadis Charalampos, Yuri Rzhanov, Maria Geraga, George Ferentinos
Feb 23, 2019
In this work, multibeam echosounder (MBES) and dual frequency sidescan sonar (SSS) data are combined to map the shallow (5–100 m) benthic habitats of the National Marine Park of Zakynthos (NMPZ), Greece, a Marine Protected Area...
Angular backscatter responses Benthic habitat mapping Marine protected area (MPA) Multi-frequency acoustic backscatter Multibeam echosounder National Marine Park of Zakynthos (NMPZ) object-based image analysis (OBIA) Seagrass mapping Sidescan sonar /dk/atira/pure/subjectarea/asjc/1900/1900 name=General Earth and Planetary Sciences /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Multi-frequency, multi-sonar mapping of shallow habitats – Efficacy and management implications in the National Marine Park of Zakynthos, Greece
Elias Fakiris, Philippe Blondel, George Papatheodorou, Dimitris Christodoulou, Xenophon Dimas, Nikos Georgiou, Stavroula Kordella, Dimitriadis Charalampos, Yuri Rzhanov, Maria Geraga, George Ferentinos
Feb 23, 2019
In this work, multibeam echosounder (MBES) and dual frequency sidescan sonar (SSS) data are combined to map the shallow (5–100 m) benthic habitats of the National Marine Park of Zakynthos (NMPZ), Greece, a Marine Protected Area...
Angular backscatter responses Benthic habitat mapping Marine protected area (MPA) Multi-frequency acoustic backscatter Multibeam echosounder National Marine Park of Zakynthos (NMPZ) object-based image analysis (OBIA) Seagrass mapping Sidescan sonar /dk/atira/pure/subjectarea/asjc/1900/1900 name=General Earth and Planetary Sciences /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M. Shchepinova, Ivan R. Corrêa Jr, David J. Hodson, Johannes Broichhagen, Edward W. Tate, Frank Reimann, Victoria Salem, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Nov 10, 2020
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic...
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.
Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M Shchepinova, Ivan R Corrêa, David J Hodson, Johannes Broichhagen, Edward W Tate, Frank Reimann, Victoria Salem, Guy A Rutter, Tricia Tan, Stephen R Bloom, Alejandra Tomas, Ben Jones
Jan 25, 2021
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic...
Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections.
Matthew D Parker, Hazel Stewart, Ola M Shehata, Benjamin B Lindsey, Dhruv R Shah, Sharon Hsu, Alexander J Keeley, David G Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F Louka, Hailey R Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E Hansford, Luke R Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew E Firth, James R Edgar, Silvana Gaudieri, Simon Mallal, COVID-19 Genomics UK (COG-UK) Consortium, Mark O Collins, Andrew A Peden, Thushan I de Silva
Aug 06, 2022
B.1.1.7 lineage SARS-CoV-2 is more transmissible, leads to greater clinical severity, and results in modest reductions in antibody neutralization. Subgenomic RNA (sgRNA) is produced by discontinuous transcription of the...
Genetically determined height and coronary artery disease.
Christopher P Nelson, Stephen E Hamby, Danish Saleheen, Jenna C Hopewell, Lingyao Zeng, Themistocles L Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O Boehm, Robert J Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W Franks, Leif Groop, Alistair S Hall, Anders Hamsten, Christian Hengstenberg, G Kees Hovingh, Erik Ingelsson, Sekar Kathiresan, Frank Kee, Inke R König, Jaspal Kooner, Terho Lehtimäki, Winifred März, Ruth McPherson, Andres Metspalu, Markku S Nieminen, Christopher J O'Donnell, Colin NA Palmer, Annette Peters, Markus Perola, Muredach P Reilly, Samuli Ripatti, Robert Roberts, Veikko Salomaa, Svati H Shah, Stefan Schreiber, Agneta Siegbahn, Unnur Thorsteinsdottir, Giovani Veronesi, Nicholas Wareham, Cristen J Willer, Pierre A Zalloua, Jeanette Erdmann, Panos Deloukas, Hugh Watkins, Heribert Schunkert, John Danesh, John R Thompson, Nilesh J Samani, CARDIoGRAM+C4D Consortium
Jun 03, 2015
Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections.
Matthew D Parker, Hazel Shaw, Ola M Shehata, Benjamin B Lindsey, Dhruv R Shah, Sharon Hsu, Alexander J Keeley, David G Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F Louka, Hailey R Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E Hansford, Luke R Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew Firth, James Edgar, Silvana Gaudieri, Simon Mallal, COVID-19 Genomics UK (COG-UK) Consortium, Mark O Collins, Andrew A Peden, Thushan I de Silva
Jul 06, 2022
B.1.1.7 lineage SARS-CoV-2 is more transmissible, leads to greater clinical severity, and results in modest reductions in antibody neutralization. Subgenomic RNA (sgRNA) is produced by discontinuous transcription of the...
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant
Stavroula Kanoni, Jennifer A Nettleton, Marie-France Hivert, Zheng Ye, Frank JA van Rooij, Dmitry Shungin, Emily Sonestedt, Julius S Ngwa, Mary K Wojczynski, Rozenn N Lemaitre, Stefan Gustafsson, Jennifer S Anderson, Toshiko Tanaka, George Hindy, Georgia Saylor, Frida Renstrom, Amanda J Bennett, Cornelia M van Duijn, Jose C Florez, Caroline S Fox, Albert Hofman, Ron C Hoogeveen, Denise K Houston, Frank B Hu, Paul F Jacques, Ingegerd Johansson, Lars Lind, Yongmei Liu, Nicola McKeown, Jose Ordovas, James S Pankow, Eric JG Sijbrands, Ann-Christine Syvänen, André G Uitterlinden, Mary Yannakoulia, M Carola Zillikens, MAGIC Investigators, Nick J Wareham, Inga Prokopenko, Stefania Bandinelli, Nita G Forouhi, L Adrienne Cupples, Ruth J Loos, Goran Hallmans, Josée Dupuis, Claudia Langenberg, Luigi Ferrucci, Stephen B Kritchevsky, Mark I McCarthy, Erik Ingelsson, Ingrid B Borecki, Jacqueline CM Witteman, Marju Orho-Melander, David S Siscovick, James B Meigs, Paul W Franks, George V Dedoussis
Jan 23, 2018
OBJECTIVE: Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose...
Physical activity attenuates the influence of FTO variants on obesity risk
Tuomas O Kilpeläinen, Lu Qi, Soren Brage, Stephen J Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, Samia Mora, Marika Kaakinen, Camilla Helene Sandholt, Christina Holzapfel, Christine S Autenrieth, Elina Hyppönen, Stéphane Cauchi, Meian He, Zoltan Kutalik, Meena Kumari, Alena Stančáková, Karina Meidtner, Beverley Balkau, Jonathan T Tan, Massimo Mangino, Nicholas J Timpson, Yiqing Song, M Carola Zillikens, Kathleen A Jablonski, Melissa E Garcia, Stefan Johansson, Jennifer L Bragg-Gresham, Ying Wu, Jana V van Vliet-Ostaptchouk, N Charlotte Onland-Moret, Esther Zimmermann, Natalia V Rivera, Toshiko Tanaka, Heather M Stringham, Günther Silbernagel, Stavroula Kanoni, Mary F Feitosa, Soren Snitker, Jonatan R Ruiz, Jeffery Metter, Maria Teresa Martinez Larrad, Mustafa Atalay, Maarit Hakanen, Najaf Amin, Christine Cavalcanti-Proença, Anders Grøntved, Göran Hallmans, John-Olov Jansson, Johanna Kuusisto, Mika Kähönen, Pamela L Lutsey, John J Nolan, Luigi Palla, Oluf Pedersen, Louis Pérusse, Frida Renström, Robert A Scott, Dmitry Shungin, Ulla Sovio, Tuija H Tammelin, Tapani Rönnemaa, Timo A Lakka, Matti Uusitupa, Manuel Serrano Rios, Luigi Ferrucci, Claude Bouchard, Aline Meirhaeghe, Mao Fu, Mark Walker, Ingrid B Borecki, George V Dedoussis, Andreas Fritsche, Claes Ohlsson, Michael Boehnke, Stefania Bandinelli, Cornelia M van Duijn, Shah Ebrahim, Debbie A Lawlor, Vilmundur Gudnason, Tamara B Harris, Thorkild IA Sørensen, Karen L Mohlke, Albert Hofman, André G Uitterlinden, Jaakko Tuomilehto, Terho Lehtimäki, Olli Raitakari, Bo Isomaa, Pål R Njølstad, Jose C Florez, Simin Liu, Andy Ness, Timothy D Spector, E Shyong Tai, Philippe Froguel, Heiner Boeing, Markku Laakso, Michael Marmot, Sven Bergmann, Chris Power, Kay-Tee Khaw, Daniel Chasman, Paul Ridker, Torben Hansen, Keri L Monda, Thomas Illig, Marjo-Riitta Järvelin, Nicholas J Wareham, Frank B Hu, Leif C Groop, Marju Orho-Melander, Ulf Ekelund, Paul W Franks, Ruth JF Loos
Nov 16, 2017
BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have...
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Rona J Strawbridge, Josée Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, Denis Rybin, John R Petrie, Mary E Travers, Nabila Bouatia-Naji, Antigone S Dimas, Alexandra Nica, Eleanor Wheeler, Han Chen, Benjamin F Voight, Jalal Taneera, Stavroula Kanoni, John F Peden, Fabiola Turrini, Stefan Gustafsson, Carina Zabena, Peter Almgren, David JP Barker, Daniel Barnes, Elaine M Dennison, Johan G Eriksson, Per Eriksson, Elodie Eury, Lasse Folkersen, Caroline S Fox, Timothy M Frayling, Anuj Goel, Harvest F Gu, Momoko Horikoshi, Bo Isomaa, Anne U Jackson, Karen A Jameson, Eero Kajantie, Julie Kerr-Conte, Teemu Kuulasmaa, Johanna Kuusisto, Ruth JF Loos, Jian'an Luan, Konstantinos Makrilakis, Alisa K Manning, María Teresa Martínez-Larrad, Narisu Narisu, Maria Nastase Mannila, John Ohrvik, Clive Osmond, Laura Pascoe, Felicity Payne, Avan A Sayer, Bengt Sennblad, Angela Silveira, Alena Stancáková, Kathy Stirrups, Amy J Swift, Ann-Christine Syvänen, Tiinamaija Tuomi, Ferdinand M van 't Hooft, Mark Walker, Michael N Weedon, Weijia Xie, Björn Zethelius, DIAGRAM Consortium, GIANT Consortium, MuTHER Consortium, CARDIoGRAM consortium, C4D Consortium, Halit Ongen, Anders Mälarstig, Jemma C Hopewell, Danish Saleheen, John Chambers, Sarah Parish, John Danesh, Jaspal Kooner, Claes-Göran Ostenson, Lars Lind, Cyrus C Cooper, Manuel Serrano-Ríos, Ele Ferrannini, Tom J Forsen, Robert Clarke, Maria Grazia Franzosi, Udo Seedorf, Hugh Watkins, Philippe Froguel, Paul Johnson, Panos Deloukas, Francis S Collins, Markku Laakso, Emmanouil T Dermitzakis, Michael Boehnke, Mark I McCarthy, Nicholas J Wareham, Leif Groop, François Pattou, Anna L Gloyn, George V Dedoussis, Valeriya Lyssenko, James B Meigs, Inês Barroso, Richard M Watanabe, Erik Ingelsson, Claudia Langenberg, Anders Hamsten, Jose C Florez
May 09, 2018
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D)....
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, John Danesh, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, Paul S de Vries, Moritz von Scheidt
Dec 08, 2022
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie PG Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger EG Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski
Oct 04, 2021
BACKGROUND: Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in...
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.
Jordi Merino, Hassan S Dashti, Sherly X Li, Chloé Sarnowski, Anne E Justice, Misa Graff, Constantina Papoutsakis, Caren E Smith, George V Dedoussis, Rozenn N Lemaitre, Mary K Wojczynski, Satu Männistö, Julius S Ngwa, Minjung Kho, Tarunveer S Ahluwalia, Natalia Pervjakova, Denise K Houston, Claude Bouchard, Tao Huang, Marju Orho-Melander, Alexis C Frazier-Wood, Dennis O Mook-Kanamori, Louis Pérusse, Craig E Pennell, Paul S de Vries, Trudy Voortman, Olivia Li, Stavroula Kanoni, Lynda M Rose, Terho Lehtimäki, Jing Hua Zhao, Mary F Feitosa, Jian'an Luan, Nicola M McKeown, Jennifer A Smith, Torben Hansen, Niina Eklund, Mike A Nalls, Tuomo Rankinen, Jinyan Huang, Dena G Hernandez, Christina-Alexandra Schulz, Ani Manichaikul, Ruifang Li-Gao, Marie-Claude Vohl, Carol A Wang, Frank JA van Rooij, Jean Shin, Ioanna P Kalafati, Felix Day, Paul M Ridker, Mika Kähönen, David S Siscovick, Claudia Langenberg, Wei Zhao, Arne Astrup, Paul Knekt, Melissa Garcia, DC Rao, Qibin Qi, Luigi Ferrucci, Ulrika Ericson, John Blangero, Albert Hofman, Zdenka Pausova, Vera Mikkilä, Nick J Wareham, Sharon LR Kardia, Oluf Pedersen, Antti Jula, Joanne E Curran, M Carola Zillikens, Jorma S Viikari, Nita G Forouhi, José M Ordovás, John C Lieske, Harri Rissanen, André G Uitterlinden, Olli T Raitakari, Jessica C Kiefte-de Jong, Josée Dupuis, Jerome I Rotter, Kari E North, Robert A Scott, Michael A Province, Markus Perola, L Adrienne Cupples, Stephen T Turner, Thorkild IA Sørensen, Veikko Salomaa, Yongmei Liu, Yun J Sung, Lu Qi, Stefania Bandinelli, Stephen S Rich, Renée de Mutsert, Angelo Tremblay, Wendy H Oddy, Oscar H Franco, Tomas Paus, Jose C Florez, Panos Deloukas, Leo-Pekka Lyytikäinen, Daniel I Chasman, Audrey Y Chu, Toshiko Tanaka
Sep 19, 2018
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two...
Aged aging Alpha-Ketoglutarate-Dependent Dioxygenase FTO Cohort Studies Energy Intake Female Fibroblast Growth Factors Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genomics Genotype Heart Diseases Humans Male Membrane Proteins Middle Aged nutrients obesity Polymorphism Single Nucleotide Receptors Retinoic Acid White People
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, Biobank Japan, EPIC-CVD, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, CARDIoGRAMplusC4D Consortium
Jan 06, 2023
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD)...
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
A. Mesut Erzurumluoglu, Mengzhen Liu, Victoria E. Jackson, Daniel R. Barnes, Gargi Datta, Carl A. Melbourne, Robin Young, Chiara Batini, Praveen Surendran, Tao Jiang, Sheikh Daud Adnan, Saima Afaq, Arpana Agrawal, Elisabeth Altmaier, Antonis C. Antoniou, Folkert W. Asselbergs, Clemens Baumbach, Laura Bierut, Sarah Bertelsen, Michael Boehnke, Michiel L. Bots, David M Brazel, John C. Chambers, Jenny Chang-Claude, Chu Chen, Janie Corley, Yi-Ling Chou, Sean P. David, Rudolf A. de Boer, Christiaan A. de Leeuw, Joe G. Dennis, Anna F. Dominiczak, Alison M. Dunning, Douglas F. Easton, Charles Eaton, Paul Elliott, Evangelos Evangelou, Jessica D. Faul, Tatiana Foroud, Alison Goate, Jian Gong, Hans J. Grabe, Jeff Haessler, Christopher Haiman, Göran Hallmans, Anke R. Hammerschlag, Sarah E. Harris, Andrew Hattersley, Andrew Heath, Chris Hsu, William G. Iacono, Stavroula Kanoni, Manav Kapoor, Jaakko Kaprio, Sharon L. Kardia, Fredrik Karpe, Jukka Kontto, Jaspal S. Kooner, Charles Kooperberg, Kari Kuulasmaa, Markku Laakso, Dongbing Lai, Claudia Langenberg, Nhung Le, Guillaume Lettre, Anu Loukola, Jian’an Luan, Pamela A. F. Madden, Massimo Mangino, Riccardo E. Marioni, Eirini Marouli, Jonathan Marten, Nicholas G. Martin, Matt McGue, Kyriaki Michailidou, Evelin Mihailov, Alireza Moayyeri, Marie Moitry, Martina Müller-Nurasyid, Aliya Naheed, Matthias Nauck, Matthew J. Neville, Sune Fallgaard Nielsen, Kari North, Markus Perola, Paul D. P. Pharoah, Giorgio Pistis, Tinca J. Polderman, Danielle Posthuma, Neil Poulter, Beenish Qaiser, Asif Rasheed, Alex Reiner, Frida Renström, John Rice, Rebecca Rohde, Olov Rolandsson, Nilesh J. Samani, Maria Samuel, David Schlessinger, Steven H Scholte, Robert A. Scott, Peter Sever, Yaming Shao, Nick Shrine, Jennifer A. Smith, John M. Starr, Kathleen Stirrups, Danielle Stram, Heather M. Stringham, Ioanna Tachmazidou, Jean-Claude Tardif, Deborah J. Thompson, Hilary A. Tindle, Vinicius Tragante, Stella Trompet, Valerie Turcot, Jessica Tyrrell, Ilonca Vaartjes, Andries R van der Leij, Peter van der Meer, Tibor V. Varga, Niek Verweij, Henry Völzke, Nicholas J. Wareham, Helen R. Warren, David R. Weir, Stefan Weiss, Leah Wetherill, Hanieh Yaghootkar, Ersin Yavas, Yu Jiang, Fang Chen, Xiaowei Zhan, Weihua Zhang, Wei Zhao, Kaixin Zhou, Philippe Amouyel, Stefan Blankenberg, Mark J. Caulfield, Rajiv Chowdhury, Francesco Cucca, Ian J. Deary, Panos Deloukas, Emanuele Di Angelantonio, Marco Ferrario, Jean Ferrières, Paul W. Franks, Tim M. Frayling, Philippe Frossard, Ian P. Hall, Caroline Hayward, Jan-Håkan Jansson, J. Wouter Jukema, Frank Kee, Satu Männistö, Andres Metspalu, Patricia B. Munroe, Børge Grønne Nordestgaard, Colin N. A. Palmer, Veikko Salomaa, Naveed Sattar, Timothy Spector, David Peter Strachan, Pim van der Harst, Eleftheria Zeggini, Danish Saleheen, Adam S. Butterworth, Louise V. Wain, Goncalo R. Abecasis, John Danesh, Martin D. Tobin, Scott Vrieze, Dajiang J. Liu, Joanna M. M. Howson
Sep 25, 2020
Abstract: Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking...
COVIDiSTRESS Global Survey dataset on psychological and behavioural consequences of the COVID-19 outbreak
Yuki Yamada, Dominik-Borna Ćepulić, Tao Coll-Martín, Stéphane Debove, Guillaume Gautreau, Hyemin Han, Jesper Rasmussen, Thao P. Tran, Giovanni A. Travaglino, Andreas Lieberoth, Angélique M. Blackburn, Loïs Boullu, Mila Bujić, Grace Byrne, Marjolein C. J. Caniëls, Ivan Flis, Marta Kowal, Nikolay R. Rachev, Vicenta Reynoso-Alcántara, Oulmann Zerhouni, Oli Ahmed, Rizwana Amin, Sibele Aquino, João Carlos Areias, John Jamir Benzon R. Aruta, Dastan Bamwesigye, Jozef Bavolar, Andrew R. Bender, Pratik Bhandari, Tuba Bircan, Huseyin Cakal, Tereza Capelos, Jiří Čeněk, Brendan Ch’ng, Fang-Yu Chen, Stavroula Chrona, Carlos C. Contreras-Ibáñez, Pablo Sebastián Correa, Irene Cristofori, Wilson Cyrus-Lai, Guillermo Delgado-Garcia, Eliane Deschrijver, Carlos Díaz, İlknur Dilekler, Vilius Dranseika, Dmitrii Dubrov, Kristina Eichel, Eda Ermagan-Caglar, Rebekah Gelpí, Rubén Flores González, Amanda Griffin, Moh Abdul Hakim, Krzysztof Hanusz, Yuen Wan Ho, Dayana Hristova, Barbora Hubena, Keiko Ihaya, Gozde Ikizer, Md. Nurul Islam, Alma Jeftic, Shruti Jha, Fernanda Pérez-Gay Juárez, Pavol Kacmar, Kalina Kalinova, Phillip S. Kavanagh, Mehmet Kosa, Karolina Koszałkowska, Raisa Kumaga, David Lacko, Yookyung Lee, Antonio G. Lentoor, Gabriel A. De Leon, Shiang-Yi Lin, Samuel Lins, Claudio Rafael Castro López, Agnieszka E. Lys, Samkelisiwe Mahlungulu, Tsvetelina Makaveeva, Salomé Mamede, Silvia Mari, Tiago A. Marot, Liz Martinez, Dar Meshi, Débora Jeanette Mola, Sara Morales-Izquierdo, Arian Musliu, Priyanka A. Naidu, Arooj Najmussaqib, Jean C. Natividade, Steve Nebel, Jana Nezkusilova, Irina Nikolova, Manuel Ninaus, Valdas Noreika, María Victoria Ortiz, Daphna Hausman Ozery, Daniel Pankowski, Tiziana Pennato, Martin Pírko, Lotte Pummerer, Cecilia Reyna, Eugenia Romano, Hafize Sahin, Aybegum Memisoglu Sanli, Gülden Sayılan, Alessia Scarpaci, Cristina Sechi, Maor Shani, Aya Shata, Pilleriin Sikka, Nidhi Sinha, Sabrina Stöckli, Anna Studzinska, Emilija Sungailaite, Zea Szebeni, Benjamin Tag, Mihaela Taranu, Franco Tisocco, Jarno Tuominen, Fidan Turk, Muhammad Kamal Uddin, Ena Uzelac, Sara Vestergren, Roosevelt Vilar, Austin Horng-En Wang, J. Noël West, Charles K. S. Wu, Teodora Yaneva, Yao-Yuan Yeh
Jan 04, 2021
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
A Mesut Erzurumluoglu, Mengzhen Liu, Victoria E Jackson, Daniel R Barnes, Gargi Datta, Carl A Melbourne, Robin Young, Chiara Batini, Praveen Surendran, Tao Jiang, Sheikh Daud Adnan, Saima Afaq, Arpana Agrawal, Elisabeth Altmaier, Antonis C Antoniou, Folkert W Asselbergs, Clemens Baumbach, Laura Bierut, Sarah Bertelsen, Michael Boehnke, Michiel L Bots, David M Brazel, John C Chambers, Jenny Chang-Claude, Chu Chen, Janie Corley, Yi-Ling Chou, Sean P David, Rudolf A de Boer, Christiaan A de Leeuw, Joe G Dennis, Anna F Dominiczak, Alison M Dunning, Douglas F Easton, Charles Eaton, Paul Elliott, Evangelos Evangelou, Jessica D Faul, Tatiana Foroud, Alison Goate, Jian Gong, Hans J Grabe, Jeff Haessler, Christopher Haiman, Göran Hallmans, Anke R Hammerschlag, Sarah E Harris, Andrew Hattersley, Andrew Heath, Chris Hsu, William G Iacono, Stavroula Kanoni, Manav Kapoor, Jaakko Kaprio, Sharon L Kardia, Fredrik Karpe, Jukka Kontto, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Markku Laakso, Dongbing Lai, Claudia Langenberg, Nhung Le, Guillaume Lettre, Anu Loukola, Jian'an Luan, Pamela AF Madden, Massimo Mangino, Riccardo E Marioni, Eirini Marouli, Jonathan Marten, Nicholas G Martin, Matt McGue, Kyriaki Michailidou, Evelin Mihailov, Alireza Moayyeri, Marie Moitry, Martina Müller-Nurasyid, Aliya Naheed, Matthias Nauck, Matthew J Neville, Sune Fallgaard Nielsen, Kari North, Markus Perola, Paul DP Pharoah, Giorgio Pistis, Tinca J Polderman, Danielle Posthuma, Neil Poulter, Beenish Qaiser, Asif Rasheed, Alex Reiner, Frida Renström, John Rice, Rebecca Rohde, Olov Rolandsson, Nilesh J Samani, Maria Samuel, David Schlessinger, Steven H Scholte, Robert A Scott, Peter Sever, Yaming Shao, Nick Shrine, Jennifer A Smith, John M Starr, Kathleen Stirrups, Danielle Stram, Heather M Stringham, Ioanna Tachmazidou, Jean-Claude Tardif, Deborah J Thompson, Hilary A Tindle, Vinicius Tragante, Stella Trompet, Valerie Turcot, Jessica Tyrrell, Ilonca Vaartjes, Andries R van der Leij, Peter van der Meer, Tibor V Varga, Niek Verweij, Henry Völzke, Nicholas J Wareham, Helen R Warren, David R Weir, Stefan Weiss, Leah Wetherill, Hanieh Yaghootkar, Ersin Yavas, Yu Jiang, Fang Chen, Xiaowei Zhan, Weihua Zhang, Wei Zhao, Wei Zhao, Kaixin Zhou, Philippe Amouyel, Stefan Blankenberg, Mark J Caulfield, Rajiv Chowdhury, Francesco Cucca, Ian J Deary, Panos Deloukas, Emanuele Di Angelantonio, Marco Ferrario, Jean Ferrières, Paul W Franks, Tim M Frayling, Philippe Frossard, Ian P Hall, Caroline Hayward, Jan-Håkan Jansson, J Wouter Jukema, Frank Kee, Satu Männistö, Andres Metspalu, Patricia B Munroe, Børge Grønne Nordestgaard, Colin NA Palmer, Veikko Salomaa, Naveed Sattar, Timothy Spector, David Peter Strachan, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium Understanding Society Scientific Group, Pim van der Harst, Eleftheria Zeggini, Danish Saleheen, Adam S Butterworth, Louise V Wain, Goncalo R Abecasis, John Danesh, Martin D Tobin, Scott Vrieze, Dajiang J Liu, Joanna MM Howson
Jan 17, 2019
Exome-wide association study of plasma lipids in >300,000 individuals.
Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David Cm Liewald, Li An Lin, Allan Linneberg, Ruth JF Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas GD Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin NA Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R Van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter WF Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Charge Diabetes Working Group, EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, Joanna MM Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
May 21, 2018
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC)...
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