Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.
Diana Zabini,
Elise Granton,
Yijie Hu,
Maria Zena Miranda,
Ulrike Weichelt,
Sandra Breuils Bonnet,
Sébastien Bonnet,
Nicholas W Morrell,
Kim A Connelly,
Steeve Provencher,
Bahil Ghanim,
Walter Klepetko,
Andrea Olschewski,
Andras Kapus,
Wolfgang M Kuebler
Jan 04, 2019
RATIONALE: Vascular remodeling in pulmonary arterial hypertension (PAH) results from smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of BMPR-II (bone morphogenetic protein receptor 2) signaling and...