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Computational Chemistry on a Budget
An increasing number of new drugs have their origin in small biotech or academia. In contrast to big pharma, these environments are often more limited in terms of resources, and this necessitates different approaches to the drug...
Validation of Performance Homogeneity of Chan-Vese Model on Selected Tumour Cells
This study aims to analyze the Chan-Vese model's performance using a variety of tumor images. The processes involve the tumors' segmentation, detecting the tumors, identifying the segmented tumor region, and extracting the...
Published by: IGI Global Scientific Publishing
Penalized likelihood estimation of the proportional hazards model for survival data with interval censoring.
This paper considers the problem of semi-parametric proportional hazards model fitting where observed survival times contain event times and also interval, left and right censoring times. Although this is not a new topic, many...
Bayesian adaptive clinical trial designs for respiratory medicine.
The use of Bayesian adaptive designs for clinical trials has increased in recent years, particularly during the COVID-19 pandemic. Bayesian adaptive designs offer a flexible and efficient framework for conducting clinical trials...
Correlation of fluorescence microscopy, electron microscopy, and NanoSIMS stable isotope imaging on a single tissue section.
Céline Loussert-Fonta, Gaëlle Toullec, Arun Aby Paraecattil, Quentin Jeangros, Thomas Krueger, Stephane Escrig, Anders Meibom
Sep 09, 2020
Correlative light and electron microscopy allows localization of specific molecules at the ultrastructural level in biological tissue but does not provide information about metabolic turnover or the distribution of labile...
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
Stephane Emond, Maya Petek, Emily J. Kay, Brennen Heames, Sean R. A. Devenish, Nobuhiko Tokuriki, Florian Hollfelder
Jul 10, 2020
Abstract: Insertions and deletions (InDels) are frequently observed in natural protein evolution, yet their potential remains untapped in laboratory evolution. Here we introduce a transposon-based mutagenesis approach (TRIAD) to...
Connectivity-based parcellation of normal and anatomically distorted human cerebral cortex.
Stephane Doyen, Peter Nicholas, Anujan Poologaindran, Lewis Crawford, Isabella M Young, Rafeael Romero-Garcia, Michael E Sughrue
Dec 15, 2021
For over a century, neuroscientists have been working toward parcellating the human cortex into distinct neurobiological regions. Modern technologies offer many parcellation methods for healthy cortices acquired through magnetic...
NR4A1 Deletion in Marginal Zone B Cells Exacerbates Atherosclerosis in Mice-Brief Report.
Meritxell Nus, Gemma Basatemur, Maria Galan, Laia Cros-Brunsó, Tian X Zhao, Leanne Masters, James Harrison, Nichola Figg, Dimitrios Tsiantoulas, Frederic Geissmann, Christoph J Binder, Andrew P Sage, Ziad Mallat
Sep 01, 2020
OBJECTIVE: NR4A orphan receptors have been well studied in vascular and myeloid cells where they play important roles in the regulation of inflammation in atherosclerosis. NR4A1 (nerve growth factor IB) is among the most highly...
Animals Atherosclerosis Cholesterol Diet Western Mice Animals Aorta Aortic Diseases Atherosclerosis B-Lymphocytes Disease Models Animal Disease Progression Gene Deletion Lymphoid Tissue Male Mice Inbred C57BL Mice Knockout Nuclear Receptor Subfamily 4 Group A Member 1 Plaque Atherosclerotic Receptors LDL Signal Transduction
A mutation of the human EPHB2 gene leads to a major platelet functional defect.
Eliane Berrou, Christelle Soukaseum, Rémi Favier, Frédéric Adam, Ziane Elaib, Alexandre Kauskot, Jean-Claude Bordet, Paola Ballerini, Stephane Loyau, Miao Feng, Karine Dias, Abbas Muheidli, Stephane Girault, Alan T Nurden, Ernest Turro, Willem H Ouwehand, Cécile V Denis, Martine Jandrot-Perrus, Jean-Philippe Rosa, Paquita Nurden, Marijke Bryckaert
Nov 22, 2018
The ephrin transmembrane receptor family of tyrosine kinases is involved in platelet function. We report the first EPHB2 variant affecting platelets in 2 siblings (P1 and P2) from a consanguineous family with recurrent bleeding...
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
Stephane Emond, Maya Petek, Emily J. Kay, Brennen Heames, Sean R. A. Devenish, Nobuhiko Tokuriki, Florian Hollfelder
Jul 28, 2021
Abstract: Insertions and deletions (InDels) are frequently observed in natural protein evolution, yet their potential remains untapped in laboratory evolution. Here we introduce a transposon-based mutagenesis approach (TRIAD) to...
Evaluation of Data Imbalance Algorithms on the Prediction of Credit Card Fraud
Winfred Yaokumah, Justice Appati, Michael Soli, Stephane Nwolley, Godlove Otoo, Julius Ludu
Oct 01, 2021
Credit card fraud has been on the rise for some years now after the introduction of card payment systems. To curb this menace, computational methods have been proposed. Unfortunately, the data available for such a study is...
Published by: IGI Global Scientific Publishing
Early identification of patients with Chagas disease at risk of developing cardiomyopathy using 2-D speckle tracking strain
Sithu Win, Monica Miranda-Schaeubinger, Ronald Gustavo Durán Saucedo, Paula Carballo Jimenez, Jorge Flores, Brandon Mercado-Saavedra, Lola Camila Telleria, Anne Raafs, Manuela Verastegui, Caryn Bern, Freddy Tinajeros, Stephane Heymans, Rachel Marcus, Robert H Gilman, Monica Mukherjee, Chagas Working Group
Jul 02, 2022
Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours
Ricardo Leão, Maarten Albersen, Leendert HJ Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J Hamilton, Klaus-Peter Dieckmann
Jun 10, 2021
CONTEXT: Clinical management of testicular germ cell tumours (GCTs) is hampered by low sensitivity and specificity of the biomarkers currently in use. Circulating microRNAs (miRs) might offer the potential to address areas of...
Impaired Punishment Learning in Conduct Disorder
Erik M. Elster, Ruth Pauli, Sarah Baumann, Stephane A. De Brito, Graeme Fairchild, Christine M. Freitag, Kerstin Konrad, Veit Roessner, Inti A. Brazil, Patricia L. Lockwood, Gregor Kohls
Apr 30, 2024
Objective: Conduct disorder (CD) has been associated with deficits in the use of punishment to guide reinforcement learning (RL) and decision making. This may explain the poorly planned and often impulsive antisocial and...
Outcomes of the NHS England National Extracorporeal Membrane Oxygenation Service for adults with respiratory failure
Alex Warren, Yi-da Chiu, Sofía S Villar, Jo-Anne Fowles, Nicola Symes, Julian Barker, Luigi Camporota, Chris Harvey, Stephane Ledot, Ian Scott, Alain Vuylsteke, NHS England-commissioned National ECMO Service
Jul 02, 2020
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is increasingly used to support adults with severe respiratory failure refractory to conventional measures. In 2011, NHS England commissioned a national service to provide...
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
Sarvenaz Metghalchi, Marie Vandestienne, Yacine Haddad, Bruno Esposito, Julien Dairou, Alain Tedgui, Ziad Mallat, Stephane Potteaux, Soraya Taleb
Jun 21, 2018
AIMS: Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix degradation. Despite considerable progress in...
The discovery and maturation of peptide biologics targeting the small G protein Cdc42
George JN Tetley, Natasha P Murphy, Stephane Bonetto, Gabriela Ivanova-Berndt, Jefferson Revell, Helen R Mott, R Neil Cooley, Darerca Owen
Jan 23, 2020
Cdc42 GTPase Kras (KRAS) biologics Cancer cancer therapeutics cell migration Cell Proliferation Cell Signaling cyclic peptide Drug Discovery Nuclear Magnetic Resonance (NMR) peptide conformation Binding Sites Cell Movement Cell Proliferation Cell-Penetrating Peptides Drug Discovery GTP Phosphohydrolases Humans Molecular Structure Neoplasm Invasiveness Neoplasms Peptides Cyclic Signal Transduction cdc42 GTP-Binding Protein ras Proteins
The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice.
Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi, Lynda Zeboudj, Andreas Giraud, Xavier Loyer, Marie Vandestienne, Julien Wain-Hobson, Bruno Esposito, Stephane Potteaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat, Soraya Taleb
Jun 21, 2018
RATIONALE: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between...
More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells.
Laura Gomez-Valero, Christophe Rusniok, Danielle Carson, Sonia Mondino, Ana Elena Pérez-Cobas, Monica Rolando, Shivani Pasricha, Sandra Reuter, Jasmin Demirtas, Johannes Crumbach, Stephane Descorps-Declere, Elizabeth L Hartland, Sophie Jarraud, Gordon Dougan, Gunnar N Schroeder, Gad Frankel, Carmen Buchrieser
Feb 18, 2019
The genus Legionella comprises 65 species, among which Legionella pneumophila is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally...
White matter microstructure of the extended limbic system in male and female youth with conduct disorder
Karen Gonzalez-Madruga, Jack Rogers, Nicola Toschi, Roberta Riccelli, Areti Smaragdi, Ignazio Puzzo, Christina Stadler, Kerstin Konrad, Christine Freitag, Stephane A. De Brito, Edmund Sonuga-Barke, Graeme Fairchild
Jan 01, 2020
Background: Previous studies of conduct disorder (CD) have reported structural and functional alterations in the limbic system. However, the white matter tracts that connect limbic regions have not been comprehensively studied....
Engineering the protein dynamics of an ancestral luciferase.
Andrea Schenkmayerova, Gaspar P Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T Bornscheuer, Jiri Damborsky
Jul 28, 2021
Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral protein...
NIH 3T3 Cells Animals Mammals Mice Luciferases Luciferases Renilla Protein Engineering Enzyme Stability Temperature Mutagenesis Binding Sites Protein Conformation Kinetics Mutation Catalysis Molecular Dynamics Simulation
Published by: Nature Communications
Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children
Colin Reilly, Nathalie Jette, Emma C. Johnson, Symon M. Kariuki, Francesca Meredith, Elaine Wirrell, Marco Mula, Mary Lou Smith, Samantha Walsh, Choong Yi Fong, Jo M. Wilmshurst, Mike Kerr, Kette Valente, Stephane Auvin
Dec 01, 2023
Limited guidance exists regarding the assessment and management of psychogenic non-epileptic seizures (PNES) in children. Our aim was to develop consensus-based recommendations to fill this gap. The members of the...
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