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The evolution of mendelian randomization for investigating drug effects.
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues investigating the associations between genetically-proxied inhibition of antihypertensive drug targets and risk of common...
Interview with Stephen Lovegrove - OH 126
Stephen Lovegrove
Jan 01, 0001
In his December 2014 interview with Michelle Dubert-Bellrichard, Stephen Lovegrove shares his story coming to Winthrop as an "out" student recently kicked out of a religious college. Lovegrove details his perception of the...
Published by: Winthrop University
Appraising the causal role of smoking in multiple diseases
BACKGROUND: The causal association between cigarette smoking and several diseases remains equivocal. The purpose of this study was to appraise the causal role of smoking in a wide range of diseases by summarizing the evidence...
NBC's Chuck Todd Said Comedian Stephen Colbert is Making a Mockery of the Political System
Winthrop University
Jan 01, 0001
Addressing the audience on media coverage of the political campaign, Chuck Todd said comedian Stephen Colbert is making a mockery of the system. The process is a mess, Todd said, but he wondered if Colbert is trying to influence...
Published by: Winthrop University
Meaning at the Crossroads
Stephen Costello
Mar 16, 2022
Stephen J. Costello holds a BA, MA, and PhD in philosophy. He has addressed two parliaments—Stormont on human rights and the European Parliament in Brussels on mental health. He has twenty-five years’ experience giving seminars...
Published by: Memorial University of Newfoundland
What indeed can be tested with an instrumental variable?
Stephen Burgess
Oct 19, 2018
An astronomer, a physicist and a mathematician are on a train in Scotland. The astronomer looks out of the window, sees a black sheep standing in a field, and remarks, “How odd. All the sheep in Scotland are black!” “No, no...
Meaning at the Crossroads
Stephen Costello
Mar 16, 2022
Stephen J. Costello holds a BA, MA, and PhD in philosophy. He has addressed two parliaments—Stormont on human rights and the European Parliament in Brussels on mental health. He has twenty-five years’ experience giving seminars...
Published by: Memorial University of Newfoundland
Causal role of high body mass index in multiple chronic diseases
The Lantern Vol. 44, No. 1, Fall 1977
Robert Brancatelli, Stephen M. Lange, Chris Kile, Lisa Ungrady, Len Ulan, Leslie Bechtel, Stuart Dearden, David Hoag, Ted Lis, Pamela Roediger, David Donia, Jonathan J. Zap
Jan 01, 0001
Onto My Love Saturday Midnight Michelle Today Firefly Black Midnight Bamboo Arms Caesaropapism A Day In My Life I Only For Stephen April 18, 1958 to July 15, 1977 with Emphasis on July 15 Ode to Little...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol-Associated Mechanisms in Etiology of Age-Related Macular Degeneration.
Multivariable Mendelian randomization
Mendelian randomization causal inference Epidemiologic Methods instrumental variables lipid fractions pleiotropy Biomarkers Causality Cholesterol HDL Cholesterol LDL Coronary Disease Genetic Pleiotropy genetic variation Humans Mathematical Computing Mendelian Randomization Analysis Models Genetic Predictive Value of Tests Risk Factors Sensitivity and Specificity Triglycerides United Kingdom
Pleiotropy robust methods for multivariable Mendelian randomization
Abstract: Mendelian randomization is a powerful tool for inferring the presence, or otherwise, of causal effects from observational data. However, the nature of genetic variants is such that pleiotropy remains a barrier to valid...
RESEARCH ARTICLE RESEARCH ARTICLES Mendelian randomization multivariable pleiotropy robust estimation
Published by: Statistics in Medicine
Mendelian randomization with invalid instruments
MR-Egger test Mendelian randomization invalid instruments Meta-Analysis pleiotropy small study bias Bias blood pressure Body Height Causality Coronary Artery Disease Genetic Pleiotropy genetic variation Humans Mendelian Randomization Analysis Meta-Analysis as Topic Models Biological Regression Analysis Respiration Risk Assessment Statistics as Topic
IGF-1 and cardiometabolic diseases
AIMS/HYPOTHESIS: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease...
Smoking and stroke
We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630...
Mendelian randomization in the bone field.
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk...
Polygenic modelling of treatment effect heterogeneity.
Mendelian randomization is the use of genetic variants to assess the effect of intervening on a risk factor using observational data. We consider the scenario in which there is a pharmacomimetic (i.e., treatment-mimicking)...
causal inference effect heterogeneity instrumental variable Mendelian randomization polygenic modelling Biological Specimen Banks Cholesterol LDL Computer Simulation Epistasis Genetic Female Genetic Heterogeneity genetic variation Humans Male Mendelian Randomization Analysis Middle Aged Multifactorial Inheritance Risk Factors United Kingdom
An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting.
Valid estimation of a causal effect using instrumental variables requires that all of the instruments are independent of the outcome conditional on the risk factor of interest and any confounders. In Mendelian randomization...
How humans can contribute to Mendelian randomization analyses.
Mendelian randomization (MR) can be variously dated as 67,1 33,2 283 or 164 (amongst others) years old. It is clear that in recent times there has been an exponential increase in publications on MR, both theoretical and...
Pleiotropy robust methods for multivariable Mendelian randomization.
Mendelian randomization is a powerful tool for inferring the presence, or otherwise, of causal effects from observational data. However, the nature of genetic variants is such that pleiotropy remains a barrier to valid causal...
Genetically proxied interleukin-6 receptor inhibition
Respiratory disease is a main feature of severe COVID-19, and the potential of IL-6 receptor blockade to increase risk of pneumonia warrants vigilance and caution in its application to treat COVID-19 https://bit.ly/34Y8Ner
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