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Results: 92
Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England.
OBJECTIVES: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. DESIGN: We developed a Bayesian model to...
A zebrafish model for Mycobacterium leprae granulomatous infection
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at ~30°C, so we sought to model...
Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England
Objectives: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. Design: We developed a Bayesian model to...
Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage.
Phthiocerol dimycocerosates (PDIMs) are a class of mycobacterial lipids that promote virulence in Mycobacterium tuberculosis and Mycobacterium marinum. It has recently been shown that PDIMs work in concert with the M....
The antecedents and consequences of affordable value innovations for emerging markets
Emerging markets offer tremendous growth opportunities for firms. While established multinational firms typically focus on premium segments in emerging markets, they often fail to leverage additional growth opportunities in...
Cognitive Rigidity, Habitual Tendencies, and Obsessive-Compulsive Symptoms
Recent theories have posited a range of cognitive risk factors for obsessive-compulsive disorder (OCD), including cognitive inflexibility and a maladaptive reliance on habits. However, empirical and methodological...
Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage
Phthiocerol dimycocerosates (PDIMs) are a class of mycobacterial lipids that promote virulence in Mycobacterium tuberculosis and Mycobacterium marinum. It has recently been shown that PDIMs work in concert with the M....
Revisiting the timetable of tuberculosis.
Tuberculosis has a much shorter incubation period than is widely thought, say Marcel A Behr and colleagues, and this has implications for prioritising research and public health strategies
Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals.
Christoph Teufel, Naresh Subramaniam, Veronika Dobler, Jesus Perez, Johanna Finnemann, Puja R Mehta, Ian M Goodyer, Paul C Fletcher
Sep 21, 2015
Cationic surfactant mediated hybridization and hydrophobization of DNA molecules at the liquid/liquid interface and their phase transfer
Murali Sastry, Ashavani Kumar, Mrunalini Pattarkine, Vidya Ramakrishnan, Krishna N. Ganesh
Jan 01, 0001
Hybridization of complementary oligonucleotides mediated by a cationic surfactant at the water/hexane interface leads to hydrophobic, double-helical DNA which may be readily phase transferred to the organic phase and cast into...
Cationic surfactant hybridization DNA water/hexane interface Substrate Hydrophobic Oligonucleotides Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
A zebrafish model for ocular tuberculosis.
Ocular tuberculosis (TB) commonly causes severe inflammation and vision loss in TB-endemic countries. The mechanism by which tuberculous infection becomes established in the eye is poorly understood. We have developed the...
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or...
BAX Calcium ER ROS TNF-mediated necrosis Calcium Channel Blockers macrophage Mitochondrion ryanodine receptors Tuberculosis Animals Apoptosis Calcium Endoplasmic Reticulum Humans Lysosomes MACROPHAGES Membrane potential Mitochondrial Mitochondria Mycobacterium Infections Nontuberculous Mycobacterium marinum Mycobacterium tuberculosis Necrosis Reactive Oxygen Species THP-1 Cells Tuberculosis Tumor Necrosis Factor-alpha Zebrafish
Studies on the formation of DNA-cationic lipid composite films and DNA hybridization in the composites
The formation of composite films of double-stranded DNA and cationic lipid molecules (octadecylamine, ODA) and the hybridization of complementary single-stranded DNA molecules in such composite films are demonstrated. The...
Coating materials Lipids Genetics molecules hybridization Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
Is Mycobacterium tuberculosis infection life long?
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis. Marcel A Behr and colleagues argue that most of these people are no longer infected
Hybridization of DNA by sequential immobilization of oligonucleotides at the air-water interface
The hybridization of DNA by sequential electrostatic and hydrogen-bonding immobilization of single-stranded complementary oligonucleotides at the air-water interface with cationic Langmuir monolayers is demonstrated. The...
Monolayers Interfaces Genetics molecules hybridization Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission.
Kevin K Takaki, Gabriel Rinaldi, Matthew Berriman, Antonio J Pagán, Lalita Ramakrishnan
Feb 03, 2021
Schistosome eggs provoke the formation of granulomas, organized immune aggregates, around them. For the host, the granulomatous response can be both protective and pathological. Granulomas are also postulated to facilitate egg...
Schistosoma egg extrusion Schistosoma egg translocation Schistosoma mansoni granulomas Helminths Humans innate immunity miracidia Schistosomiasis Zebrafish Animals Feces Granuloma Granuloma Foreign-Body Humans Immunity Innate Intestines MACROPHAGES Mice Ovum Schistosoma mansoni Schistosomiasis mansoni Zebrafish
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response
Kevin K. Takaki, Francisco J. Roca, Gabriele Schramm, Ruud H. P. Wilbers, Wannaporn Ittiprasert, Paul J. Brindley, Gabriel Rinaldi, Matthew Berriman, Lalita Ramakrishnan, Antonio J. Pagán
Jan 29, 2021
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of...
TNF induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport
Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to...
Delay of Initial Feeding of Zebrafish Larvae Until 8 Days Postfertilization Has No Impact on Survival or Growth Through the Juvenile Stage.
The use of early-stage zebrafish for biomedical research spans early organogenesis to free-swimming larva. A key benefit of this model organism is that repeated assessments spanning several days can be performed of individual...
Elongational stalling activates mitoribosome-associated quality control.
Nirupa Desai, Hanting Yang, Viswanathan Chandrasekaran, Razina Kazi, Michal Minczuk, V Ramakrishnan
Dec 01, 2020
The human mitochondrial ribosome (mitoribosome) and associated proteins regulate the synthesis of 13 essential subunits of the oxidative phosphorylation complexes. We report the discovery of a mitoribosome-associated quality...
Cryoelectron Microscopy Electron Transport Complex IV Escherichia coli Exoribonucleases HEK293 Cells Humans Mitochondrial Proteins Mitochondrial Ribosomes Nuclear Proteins Peptide Termination Factors Protein Domains RNA Transfer RNA-Binding Proteins Ribosomal Proteins Transcription Elongation Genetic Transcriptional Elongation Factors
Latent Tuberculosis
The term latent tuberculosis (TB) was coined two centuries ago to describe post-mortem tuberculous pathology in the absence of ante-mortem tuberculosis manifestations. However, the meaning of the term has changed with each...
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