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Results: 29
Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device.
PURPOSE: To describe the feasibility of peripheral OCT imaging in retinal diseases using a novel full-field device. METHODS: A total of 134 consecutive eyes were referred and imaged on the Optos Silverstone swept-source OCT...
Intracellular SERS nanoprobes for distinction of different neuronal cell types.
Distinction between closely related and morphologically similar cells is difficult by conventional methods especially without labeling. Using nuclear-targeted gold nanoparticles (AuNPs) as intracellular probes we demonstrate the...
Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging
Simrat K Sodhi, Austin Pereira, Jonathan D Oakley, John Golding, Carmelina Trimboli, Daniel B Russakoff, Netan Choudhry
Mar 18, 2022
PURPOSE: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using...
Finite Element Modeling of Hot Compression Testing of Titanium Alloys
Patryk Jedrasiak, Hugh Shercliff, Sumeet Mishra, Christopher S Daniel, Joao Quinta da Fonseca
Oct 24, 2022
This paper presents experimental results and finite element analysis of hot upsetting of titanium alloys Ti64
and Ti407 using a dilatometer in loading mode. All samples showed barrelling, as a consequence of an
inhomogeneous...
Investigating biomechanical noise in neuroblastoma cells using the quartz crystal microbalance.
biomechanical noise frequency stability neuroblastoma cells quartz crystal microbalance Biosensing Techniques Cell Line Tumor Cell Movement Cell Size Elastic Modulus Equipment Design Equipment Failure Analysis Humans Micro-Electrical-Mechanical Systems Neuroblastoma Neurons Reproducibility of Results Sensitivity and Specificity Signal-To-Noise Ratio Stress Mechanical
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal CAG expansion in exon 1 of the huntingtin (HTT) gene. Given its genetic basis it is possible to study patients both in the...
Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging
Simrat K Sodhi, Austin Pereira, Jonathan D Oakley, John Golding, Carmelina Trimboli, Daniel B Russakoff, Netan Choudhry
Feb 14, 2022
Visualizing electromagnetic fields at the nanoscale by single molecule localization.
Christian Steuwe, Miklos Erdelyi, G Szekeres, M Csete, Jeremy J Baumberg, Sumeet Mahajan, Clemens F Kaminski
Jun 08, 2015
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal CAG expansion in exon 1 of the huntingtin (HTT) gene. Given its genetic basis it is possible to study patients both in the...
Published by: Chemical science
Observing Single Molecules Complexing with Cucurbit[7]uril through Nanogap Surface-Enhanced Raman Spectroscopy.
Daniel O Sigle, Setu Kasera, Lars O Herrmann, Aniello Palma, Bart de Nijs, Felix Benz, Sumeet Mahajan, Jeremy J Baumberg, Oren A Scherman
Jan 18, 2016
A Clinical Practice Guideline for the Management of Patients With Degenerative Cervical Myelopathy
Michael G Fehlings, Lindsay A Tetreault, K Daniel Riew, James W Middleton, Bizhan Aarabi, Paul M Arnold, Darrel S Brodke, Anthony S Burns, Simon Carette, Robert Chen, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, James S Harrop, Langston T Holly, Sukhvinder Kalsi-Ryan, Mark Kotter, Brian K Kwon, Allan R Martin, James Milligan, Hiroaki Nakashima, Narihito Nagoshi, John Rhee, Anoushka Singh, Andrea C Skelly, Sumeet Sodhi, Jefferson R Wilson, Albert Yee, Jeffrey C Wang
Sep 29, 2018
Study Design: Guideline development. Objectives: The objective of this study is to develop guidelines that outline how to best manage (1) patients with mild, moderate, and severe myelopathy and (2) nonmyelopathic patients with...
Comparison Of Two Total Intravenous Anaesthesia Techniques
Babita Ramdev*, Sapna Bansal, Dinesh K. Sharma, Sangita R. Sharma, Gurdeep S. Sodhi and Jasbir Kaur.
Apr 16, 2015
Introduction: T.I.V.A has many advantages over inhalational anaesthetics . The drugs used for T.I.VA. have a quicker onset, recovery and minimal side effects .This study was conducted to compare the two T.I.V.A techniques...
Published by: IJHS Medical Association
Comparison Of Two Total Intravenous Anaesthesia Techniques
Babita Ramdev*, Sapna Bansal, Dinesh K. Sharma, Sangita R. Sharma, Gurdeep S. Sodhi and Jasbir Kaur.
Apr 16, 2015
Introduction: T.I.V.A has many advantages over inhalational anaesthetics . The drugs used for T.I.VA. have a quicker onset, recovery and minimal side effects .This study was conducted to compare the two T.I.V.A techniques...
Published by: IJHS Medical Association
Copper-catalyzed rearrangement of oximes into primary amides
Sumeet Kumar Sharma, Simon D Bishopp, C L Allen, R Lawrence, M J Bamford, A A Lapkin, Pawel Plucinski, R J Watson, Jonathan M J Williams
Aug 17, 2011
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)(2) (1-2 mol %) was found to be effective for this transformation at 80 C. The...
Copper-catalyzed rearrangement of oximes into primary amides
Sumeet Kumar Sharma, Simon D Bishopp, C L Allen, R Lawrence, M J Bamford, A A Lapkin, Pawel Plucinski, R J Watson, Jonathan M J Williams
Aug 17, 2011
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)(2) (1-2 mol %) was found to be effective for this transformation at 80 C. The...
DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface.
Christine Lock, Janell Kwok, Sumeet Kumar, Azlina Ahmad-Annuar, Vairavan Narayanan, Adeline SL Ng, Yi Jayne Tan, Nagaendran Kandiah, Eng-King Tan, Zofia Czosnyka, Marek Czosnyka, John D Pickard, Nicole C Keong
Feb 22, 2019
Normal pressure hydrocephalus (NPH) is a syndrome comprising gait disturbance, cognitive decline and urinary incontinence that is an unique model of reversible brain injury, but it presents as a challenging spectrum of disease...
Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease.
Adriana Huertas-Vazquez, Christopher P Nelson, Xiuqing Guo, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Jo Ayala, Katherine Jerger, Harpriya Chugh, WTCCC+, Peter S Braund, Panos Deloukas, Alistair S Hall, Anthony J Balmforth, Michelle Jones, Kent D Taylor, Sara L Pulit, Christopher Newton-Cheh, Karen Gunson, Jonathan Jui, Jerome I Rotter, Christine M Albert, Nilesh J Samani, Sumeet S Chugh
Nov 17, 2017
BACKGROUND: Recent genome-wide association studies (GWAS) have identified novel loci associated with sudden cardiac death (SCD). Despite this progress, identified DNA variants account for a relatively small portion of overall...
Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ.
David J Swan, Dominik Aschenbrenner, Christopher A Lamb, Krishnendu Chakraborty, Jonathan Clark, Sumeet Pandey, Karin R Engelhardt, Rui Chen, Athena Cavounidis, Yuchun Ding, Natalio Krasnogor, Christopher D Carey, Meghan Acres, Stephanie Needham, Andrew J Cant, Peter D Arkwright, Anita Chandra, Klaus Okkenhaug, Holm H Uhlig, Sophie Hambleton
May 16, 2019
Phosphoinositide 3-kinase δ (PI3Kδ), a lipid kinase consisting of a catalytic (p110δ, encoded by PIK3CD) and a regulatory subunit (p85, encoded by PIK3R1), generates the second messenger phosphatidylinositol...
Clinical Outcomes After Ventriculo-Peritoneal Shunting in Patients With Classic vs. Complex NPH.
Eng Tah Goh, Christine Lock, Audrey Jia Luan Tan, Bee Ling Tan, Sai Liang, Robin Pillay, Sumeet Kumar, Azlina Ahmad-Annuar, Vairavan Narayanan, Janell Kwok, Yi Jayne Tan, Adeline SL Ng, Eng King Tan, Zofia Czosnyka, Marek Czosnyka, John D Pickard, Nicole C Keong
Jul 26, 2022
Objective: Normal pressure hydrocephalus (NPH) is a neurological condition characterized by a clinical triad of gait disturbance, cognitive impairment, and urinary incontinence in conjunction with ventriculomegaly. Other...
Clinical Outcomes After Ventriculo-Peritoneal Shunting in Patients With Classic vs. Complex NPH.
Eng Tah Goh, Christine Lock, Audrey Jia Luan Tan, Bee Ling Tan, Sai Liang, Robin Pillay, Sumeet Kumar, Azlina Ahmad-Annuar, Vairavan Narayanan, Janell Kwok, Yi Jayne Tan, Adeline SL Ng, Eng King Tan, Zofia Czosnyka, Marek Czosnyka, John D Pickard, Nicole C Keong
Sep 02, 2022
OBJECTIVE: Normal pressure hydrocephalus (NPH) is a neurological condition characterized by a clinical triad of gait disturbance, cognitive impairment, and urinary incontinence in conjunction with ventriculomegaly. Other...
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M Croft, Carsten Posovszky, Astor Rodrigues, Richard K Russell, Farah Barakat, Marcus KH Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C Matte, Kimberly C Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A Baeumler, Tudor A Fulga, Eli M Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C Barrett, Abdul Elkadri, Anne M Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B Snapper, Neil Shah, Aleixo M Muise, David C Wilson, Holm H Uhlig, Carl A Anderson
Jan 31, 2020
Adult Age of Onset Case-Control Studies Child Child Preschool Cohort Studies Female Genes Recessive Genetic Predisposition to Disease genetic variation Humans Infant Infant Newborn Inflammatory Bowel Diseases Loss of Function Mutation Male Mosaicism Multifactorial Inheritance Mutation NADPH Oxidase 2 Pedigree Primary Immunodeficiency Diseases Risk Factors Exome Sequencing
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M Croft, Carsten Posovszky, Astor Rodrigues, Richard K Russell, Farah Barakat, Marcus K H Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C Matte, Kimberly C Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A Baeumler, Tudor A Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C Barrett, Abdul Elkadri, Anne M Griffiths, Scott B Snapper, Neil Shah, Aleixo M Muise, David C Wilson, Holm H Uhlig, Carl A Anderson
Mar 25, 2020
Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients...
Published by: Nature Communications
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