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Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Dec 16, 2019
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Feb 19, 2020
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Published by: ACS omega
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman
Dec 06, 2019
The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via phosphopeptide...
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E. Stokes, Bryn Hardwick, David J. Huggins, Amy Emery, Dominique L. Kunciw, Marko Hyvönen, David R. Spring, Grahame J. McKenzie, Ashok R. Venkitaraman
Nov 03, 2020
Abstract: The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via...
The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis.
Alexis Leah Braun, Francesco Meghini, Gema Villa-Fombuena, Morgane Guermont, Elisa Fernandez-Martinez, Zhang Qian, Maria Dolores Martín-Bermudo, Acaimo González-Reyes, David Moore Glover, Yuu Kimata
Jun 29, 2021
A feature of metazoan reproduction is the elimination of maternal centrosomes from the oocyte. In animals that form syncytial cysts during oogenesis, including Drosophila and human, all centrosomes within the cyst migrate to the...
Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells.
Souhayla El Maadidi, Alexander NR Weber, Precious Motshwene, Jan Moritz Schüssler, Daniel Backes, Sabine Dickhöfer, Hui Wang, Xiao Liu, Magno Delmiro Garcia, Christoph Taumer, Boumediene Soufi, Olaf-Oliver Wolz, Sascha N Klimosch, Mirita Franz-Wachtel, Boris Macek, Nicholas J Gay
Sep 10, 2020
Toll-like receptors (TLRs) are important sentinels of bacterial and viral infection and thus fulfil a critical sensory role in innate immunity. Polo-like kinases (PLKs), a five membered family of Ser/Thr protein kinases, have...
Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.
Hongqing Liang, Alessandro Esposito, Siddharth De, Suzan Ber, Philippe Collin, Uttam Surana, Ashok R Venkitaraman
Jan 25, 2021
The G2 checkpoint monitors DNA damage, preventing mitotic entry until the damage can be resolved. The mechanisms controlling checkpoint recovery are unclear. Here, we identify non-genetic heterogeneity in the fidelity and timing...
Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.
While the immune cell adaptor protein SKAP1 mediates LFA-1 activation induced by antigen-receptor (TCR/CD3) ligation on T-cells, it is unclear whether the adaptor interacts with other mediators of T-cell function. In this...
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Oct 31, 2019
Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear...
D. melanogaster Spd-2 Cell Biology centriole Centrosome feedback loop pericentriolar material polo kinase Animals Centrosome Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Feedback Physiological Homeodomain Proteins Mitosis Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases
Optimal home energy management under hybrid photovoltaic-storage uncertainty
Energy storage and demand response (DR) resources, in combination with intermittent renewable generation, are expected to provide domestic customers with the ability to reducing their electricity consumption. This study...
Quantification of Additional Reinforcement Cost from Severe 3-Phase Imbalance
This letter is an enhancement to our previous paper that quantifies additional reinforcement costs (ARCs) for low voltage (LV) assets under moderate degree of 3-phase imbalance. The original formulas cause an overestimation of...
Quantification of Additional Reinforcement Cost from Severe 3-Phase Imbalance
This letter is an enhancement to our previous paper that quantifies additional reinforcement costs (ARCs) for low voltage (LV) assets under moderate degree of 3-phase imbalance. The original formulas cause an overestimation of...
Optimal home energy management under hybrid photovoltaic-storage uncertainty
Energy storage and demand response (DR) resources, in combination with intermittent renewable generation, are expected to provide domestic customers with the ability to reducing their electricity consumption. This study...
Small Molecules as Probes for Cell Division and Intracellular Transport
Ulf Peters
Jan 01, 0001
Cell-permeable small molecules that can act on their targets on fast time scales are powerful probes of cell division mechanisms and intracellular transport processes. Phenotype-based screens with chemical libraries have been...
Published by: Rockefeller University
Analysis of Long-term Indicators in the British Balancing Market
Proactive participation of uncertain renewable generation in the day-ahead (DA) wholesale market effectively reduces the system marginal price and carbon emissions, whilst significantly increasing the volumes of real-time...
Balancing market costs Flexible load Indexes long-term driving factors Pricing Real-time systems Renewable energy sources Resource management Vehicles /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Reliability planning of active distribution systems incorporating regulator requirements and network-reliability equivalents
This paper presents an integrated approach for reliability planning and risk estimation in active distribution systems. By incorporating the use of accurate reliability equivalents for different MV/LV networks and load...
Reliability planning of active distribution systems incorporating regulator requirements and network-reliability equivalents
This paper presents an integrated approach for reliability planning and risk estimation in active distribution systems. By incorporating the use of accurate reliability equivalents for different MV/LV networks and load...
Distributionally Robust Hydrogen Optimization with Ensured Security and Multi-Energy Couplings
Power-to-gas (P2G) can convert excessive renewable energy into hydrogen via electrolysis, which can then be transported by natural gas systems to bypass constrained electricity systems. However, the injection of hydrogen could...
Nutritional Labelling and Purchase Intention
With the aim of preventing malnutrition, it has been proposed to provide information to consumers about the nutritional content of food using labelling on packages to promote healthier eating habits. Since the way in which the...
Published by: IGI Global Scientific Publishing
An IoT-based Thermal Modelling of Dwelling Rooms to Enable Flexible Energy Management
The thermal model of dwellings is the basis for flexible energy management of smart homes, where heating load is a big part of demand. It can also be operated as virtual energy storage to enable flexibility. However, constrained...
Analysis of Long-term Indicators in the British Balancing Market
Proactive participation of uncertain renewable generation in the day-ahead (DA) wholesale market effectively reduces the system marginal price and carbon emissions, whilst significantly increasing the volumes of real-time...
Balancing market costs Flexible load Indexes long-term driving factors Pricing Real-time systems Renewable energy sources Resource management Vehicles /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Mirrored Images: The Passion and the First Crusade in a Fourteenth-Century Parisian Illuminated Manuscript (Paris, Bibliotheque Nationale de France, MS fr. 352)
Susanna A. Throop
Jan 01, 0001
This lavish mid-fourteenth-century Parisian illuminated manuscript (Paris, Bibliothèque nationale de France, MS fr. 352) combines a description of the Holy Land with an abridged version of the history and continuations of...
Passion of Christ First Crusade chivalry Jerusalem Philip VI of France Godfrey of Bouillon Eracles Sainte-Chapelle Arts and Humanities European History History History of Christianity History of Religion Medieval History Medieval Studies
Published by: Ursinus College
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