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The Ursinus Weekly, February 18, 1918

Purd Eugene Deitz, George Leslie Omwake, Philip May

Jan 01, 0001

Founders' Day a most enjoyable occasion Winter meeting of the Board of Directors Peer Gynt recital crowning event Zwinglian prize essay: War and education Literary societies Scrubs are again defeated William H. Yoch...

Ursinus College Collegeville Pennsylvania newspaper Basketball YMCA YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History

Published by: Ursinus College

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The Ursinus Weekly, December 3, 1917

Purd Eugene Deitz, George Leslie Omwake, Calvin D. Yost, Sr., H. C. Hoover

Jan 01, 0001

Lecture by John Kendrick Bangs Ursinus 0, Muhlenberg 0: Rival teams battle to a scoreless tie in big Thanksgiving Day game Ursinus receives substantial bequest Engagement announced Alan Seeger College directory Fall...

Ursinus College Collegeville Pennsylvania newspaper Rebecca Miller Emma C. Hunsicker Football YMCA YWCA Schaff literary society Zwinglian literary society cultural history Higher Education Liberal Studies Social History United States History

Published by: Ursinus College

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Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants

Kathryn J. C. Watt, Richard M. Meade, Robert J. Williams, Jody M. Mason

Jun 15, 2022

Parkinson's Disease (PD) is characterized by the accumulation of Lewy bodies in dopaminergic neurons. The main protein component of Lewy bodies, α-synuclein (αS), is also firmly linked to PD through the identification of a...

amyloid aggregation early-onset Parkinson's disease Peptides /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1314 name=Physiology /dk/atira/pure/subjectarea/asjc/2800/2805 name=Cognitive Neuroscience /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology

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A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles

Richard Meade, Robert J Williams, Jody Mason

Aug 19, 2020

α-Synuclein (αS) deposition is a defining characteristic of Parkinson’s disease (PD) pathology, and other synucleinopathies. αS aggregates in disease, leading to the generation of neuronal inclusions known as Lewy bodies....

/dk/atira/pure/subjectarea/asjc/2800/2808 name=Neurology /dk/atira/pure/subjectarea/asjc/2700/2728 name=Clinical Neurology /dk/atira/pure/subjectarea/asjc/2800/2804 name=Cellular and Molecular Neuroscience

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The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein

Richard Meade, Kimberley Morris, Kathryn Watt, Robert J Williams, Jody Mason

Dec 05, 2020

Aggregation of alpha-Synuclein (aS) is widely regarded as a key factor in neuronal cell death, leading to a wide range of synucleinopathies that includes Parkinson’s Disease. Development of therapeutics has therefore focused on...

ALPHA-SYNUCLEIN Peptide Amyloid AGGREGATION primary nucleation Lipid vesicles Parkinson's Disease

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Cover Image for RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemic.

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RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemic.

Mark Griffiths, Susanna Meade, Charlotte Summers, Daniel Francis McAuley, Alastair Proudfoot, Marta Montero Baladia, Paul M Dark, Kate Diomede, Simon J Finney, Lui G Forni, Chris Meadows, Ian A Naldrett, Brijesh Patel, Gavin D Perkins, Mark A Samaan, Laurence Sharifi, Ganesh Suntharalingam, Nicholas T Tarmey, Harriet F Young, Matt P Wise, Peter M Irving

May 31, 2021

BACKGROUND: COVID-19 has become the most common cause of acute respiratory distress syndrome (ARDS) worldwide. Features of the pathophysiology and clinical presentation partially distinguish it from 'classical' ARDS. A Research...

ARDS covid-19 Assisted Ventilation Critical Care non invasive ventilation viral infection covid-19 COVID-19 Testing Humans Pandemics Research Respiration Artificial Respiratory Distress Syndrome SARS-CoV-2 United Kingdom

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Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation

James Torpey, Richard Meade, Ravina Mistry, Jody Mason, Jillian Madine

Oct 15, 2020

α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development fora range of neurodegenerative conditions, collectively termed synucleinopathies. Here,we probe the mechanism of action of a peptide 4554W...

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Margaret Audrey Padgett Golden

Susanna O Lee

Jan 01, 0001

Published by: Winthrop University

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Randomized controlled pilot trial of naloxone-on-release to prevent post-prison opioid overdose deaths

MKB Parmar, J Strang, L Choo, AM Meade, SM Bird

Aug 30, 2017

Fatality Naloxone opioid-overdose post-release Prevention Prisoners randomization trial

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A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles

Richard Meade, Robert J Williams, Jody Mason

Aug 19, 2020

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Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants

Kathryn J. C. Watt, Richard M. Meade, Robert J. Williams, Jody M. Mason

Jun 15, 2022

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Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants

Kathryn J. C. Watt, Richard M. Meade, Robert J. Williams, Jody M. Mason

Dec 31, 2022

α-synuclein (αS) is the key component of synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. αS was first linked to PD through the identification of point mutations in...

amyloid aggregation early onset Parkinson's disease Lipid vesicles Peptide /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology

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Cover Image for A downsized and optimised intracellular library-derived peptide prevents alpha-synuclein primary nucleation and toxicity without impacting upon lipid binding

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A downsized and optimised intracellular library-derived peptide prevents alpha-synuclein primary nucleation and toxicity without impacting upon lipid binding

Richard M. Meade, Kathryn J. C. Watt, Robert J. Williams, Jody M. Mason

Dec 03, 2021

Misfolding and aggregation of alpha-synuclein (αS) within dopaminergic neurons is a key factor in the development and progression of a group of age-related neurodegenerative diseases, termed synucleinopathies, that include...

Parkinson's Disease amyloid aggregation Lipid vesicles Peptide primary nucleation /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/1300/1315 name=Structural Biology /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology

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A downsized and optimised intracellular library-derived peptide prevents alpha-synuclein primary nucleation and toxicity without impacting upon lipid binding

Richard M. Meade, Kathryn J. C. Watt, Robert J. Williams, Jody M. Mason

Dec 03, 2021

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Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants

Kathryn J. C. Watt, Richard M. Meade, Robert J. Williams, Jody M. Mason

Dec 31, 2022

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The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein

Richard Meade, Kimberley Morris, Kathryn Watt, Robert J Williams, Jody Mason

Dec 05, 2020

ALPHA-SYNUCLEIN Peptide Amyloid AGGREGATION primary nucleation Lipid vesicles Parkinson's Disease

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Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation

James Torpey, Richard Meade, Ravina Mistry, Jody Mason, Jillian Madine

Oct 15, 2020

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Evolutionary divergence in brain size between migratory and resident birds

D Sol, N Garcia, A Iwaniuk, K Davis, A Meade, W A Boyle, Tamas Szekely

Mar 10, 2010

Despite important recent progress in our understanding of brain evolution, controversy remains regarding the evolutionary forces that have driven its enormous diversification in size. Here, we report that in passerine birds...

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An N-terminal alpha-Synuclein fragment binds lipid vesicles to modulate lipid induced aggregation

Richard Meade, Scott Allen, Chris Williams, Simon Tang, Matthew P Crump, Jody Mason

Sep 20, 2023

Misfolding and aggregation of alpha-synuclein (αS) into toxic conformations is involved in numerous neurodegenerative diseases. In Parkinson's disease (PD), this occurs within dopaminergic neurons, causing cell death and...

Parkinson's Disease ALPHA-SYNUCLEIN Amyloid Lipids Peptide protein aggregation /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/subjectarea/asjc/3100/3100 name=General Physics and Astronomy /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science

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An N-terminal alpha-Synuclein fragment binds lipid vesicles to modulate lipid induced aggregation

Richard Meade, Scott Allen, Chris Williams, Simon Tang, Matthew P Crump, Jody Mason

Sep 20, 2023

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Vaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virus.

Fatima Amanat, Shirin Strohmeier, Philip S Meade, Nicholas Dambrauskas, Barbara Mühlemann, Derek J Smith, Vladimir Vigdorovich, D Noah Sather, Lynda Coughlan, Florian Krammer

Jan 28, 2022

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Cover Image for Mirrored Images: The Passion and the First Crusade in a Fourteenth-Century Parisian Illuminated Manuscript (Paris, Bibliotheque Nationale de France, MS fr. 352)

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Mirrored Images: The Passion and the First Crusade in a Fourteenth-Century Parisian Illuminated Manuscript (Paris, Bibliotheque Nationale de France, MS fr. 352)

Susanna A. Throop

Jan 01, 0001

This lavish mid-fourteenth-century Parisian illuminated manuscript (Paris, Bibliothèque nationale de France, MS fr. 352) combines a description of the Holy Land with an abridged version of the history and continuations of...

Passion of Christ First Crusade chivalry Jerusalem Philip VI of France Godfrey of Bouillon Eracles Sainte-Chapelle Arts and Humanities European History History History of Christianity History of Religion Medieval History Medieval Studies

Published by: Ursinus College

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A Brief History of Cryptology and Winthrop

Susanna O Lee

Jan 01, 0001

This is a brief history of the Cryptology program and Winthrop College's involvement in the program in World War II

Published by: Winthrop University

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Homocysteine and small vessel stroke

Susanna C Larsson, Matthew Traylor, Hugh S Markus

Mar 19, 2019

OBJECTIVE: Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be...

Brain Ischemia homocysteine Humans Mendelian Randomization Analysis Microvessels Polymorphism Single Nucleotide stroke Vitamin B 12

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Mary Sue Britton McElveen

Susanna O Lee

Jan 01, 0001

Published by: Winthrop University