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Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism.
The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of proteins...
Is mRNA decapping by ApaH like phosphatases present in eukaryotes beyond the Kinetoplastida?
BACKGROUND: ApaH like phosphatases (ALPHs) originate from the bacterial ApaH protein and have been identified in all eukaryotic super-groups. Only two of these proteins have been functionally characterised. We have shown that...
Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.
Terry K Smith, Nadina Vasileva, Eva Gluenz, Stephen Terry, Neil Portman, Susanne Kramer, Mark Carrington, Shulamit Michaeli, Keith Gull, Gloria Rudenko
May 29, 2018
BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian...
Freedom of expression as self-restraint
In my recent book Freedom of Expression as Self-Restraint, I expound and defend the moral principle of freedom of expression. This article recounts a few of the main strands of the exposition in that book, and it...
MH Kramer
May 09, 2022
Factors Affecting Translation of Messenger RNA's In Vitro: Use of a GTP Analogue to Investigate Rates of Polypeptide Chain Elongation
Fred Russell Kramer
Jan 01, 0001
The order of addition of amino acids to a growing protein is determined by the codon sequence of a messenger RNA molecule. This translation process was studied in vitro with a cell-free protein synthesis system derived from...
Published by: Rockefeller University
Ethical Dilemmas and Big Data
Using big data in organizations has the potential to improve innovation, accuracy, and efficiency. Big data is also connected with risks for both the organization and society at large. It is therefore vital to improve our...
Published by: IGI Global Scientific Publishing
There's Nothing Quasi about Quasi-Realism
MH Kramer
Feb 09, 2017
This paper seeks to clarify and defend the proposition that moral realism is best elaborated as a moral doctrine. I begin by upholding Ronald Dworkin’s anti-Archimedean critique of the error theory against some strictures by...
The Role of Language in Structuring Social Networks Following Market Integration in a Yucatec Maya Population.
Language is the human universal mode of communication, and is dynamic and constantly in flux accommodating user needs as individuals interface with a changing world. However, we know surprisingly little about how language...
Match-Making Reactors to Chemistry
Flavien Susanne, Benjamin Martin, Michel Aubry, Joerg Sedelmeier, Fabio Lima, Serbuelent Sevinc, Lorenzo Piccioni, Julien Haber, Berthold Schenkel, Francesco Venturoni
Jan 25, 2018
The focus of this study was to develop a chemical reaction sequence toward a key benzoxazole building block, required for clinical manufacturing of a lead candidate in the respiratory disease area. The chemistry consisted of...
The Tocque Formula and Newfoundland English
Susanne Wagner
Sep 30, 2014
Summer settlements had been established on the island of Newfoundland since at least the 17th century. A dominion of the British Crown, Newfoundland entered Confederation as the tenth Canadian province (Newfoundland and...
Published by: Atlantic Provinces Linguistic Association
Family Capital in Family Businesses
Family capital is all social, human, and financial capital a family has at their disposal in the family to advance the business. Family capital is the pool of resources unique to family business and it has the potential for...
Entrepreneurship & Innovation Business and Management Small and Medium Enterprises Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Ready or Not (To Apply)? Autoregulatory Dysfunction Indices and Lesion Progression in Traumatic Brain Injury.
Susanne Muehlschlegel
Jan 06, 2020
Failure of cerebral autoregulation has been linked to unfavourable outcome after traumatic brain injury. Preliminary evidence from a small retrospective single-center analysis suggest that autoregulatory dysfunction may be...
Academic temporalities
This article focuses on academic temporalities to consider the rhythms, repetitions and discontinuities of academic work. Using a photo-serial methodology which generated an archive of images taken at the same time of day for...
The Tocque Formula and Newfoundland English
Susanne Wagner
Sep 30, 2014
Summer settlements had been established on the island of Newfoundland since at least the 17th century. A dominion of the British Crown, Newfoundland entered Confederation as the tenth Canadian province (Newfoundland and...
Published by: Atlantic Provinces Linguistic Association
Mutations of the nACh Receptor M4 Helix Reveal Different Phenotypes in Different Expression Systems
The role of the outermost helix (M4) in the pentameric ligand-gated ion channel (pLGIC) family is currently not fully understood. It is known that M4 is important for receptor assembly, possibly via interactions with neighboring...
Aerobic and Strength Training in Concomitant Metabolic Syndrome and Type 2 Diabetes
Conrad P Earnest, Neil M Johannsen, Damon L Swift, Fiona B Gillison, Catherine R Mikus, Alejandro Lucia, Kimberly Kramer, Carl J Lavie, Timothy S Church
Jul 01, 2014
Concomitant type 2 diabetes (T2D) and metabolic syndrome exacerbates mortality risk; yet, few studies have examined the effect of combining (AER+RES) aerobic (AER) and resistance (RES) training for individuals with T2D and...
Transporters as information processors in bacterial signalling pathways
Transporters are essential players in bacterial growth and survival, since they are key for uptake of nutrients on the one hand, and for defence against endogenous and environmental stresses on the other hand. Remarkably, in...
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