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Results: 41
The specter of empty countrysides and wetlands—Impact of hunting take on birds in Indo-Burma
DL Yong, A Jain, SU Chowdhury, E Denstedt, K Khammavong, P Milavong, TDW Aung, ET Aung, A Jearwattanakanok, W Limparungpatthanakij, R Angkaew, K Sinhaseni, TT Le, HB Nguyen, P Tang, P Taing, VR Jones, B Vorsak
Mar 08, 2022
Hunting for the wild meat trade, medicines and other human uses has decimated Indo-Burma's vertebrate biota and has led to widespread defaunation. Yet, there is surprisingly little data on how hunting impacts wild bird...
Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.
Htin Lin Aung, Thanda Tun, Danesh Moradigaravand, Claudio U Köser, Wint Wint Nyunt, Si Thu Aung, Thandar Lwin, Kyi Kyi Thinn, John A Crump, Julian Parkhill, Sharon J Peacock, Gregory M Cook, Philip C Hill
May 24, 2016
Is bigger better? The relationship between size and reproduction in female Asian elephants.
JAH Crawley, HS Mumby, SN Chapman, M Lahdenperä, KU Mar, W Htut, A Thura Soe, HH Aung, V Lummaa
Apr 26, 2018
The limited availability of resources is predicted to impose trade-offs between growth, reproduction and self-maintenance in animals. However, although some studies have shown that early reproduction suppresses growth...
Recent changes in the number of spoon-billed sandpipers Calidris pygmaea wintering on the Upper Gulf of Mottama in Myanmar
Pyae-Phyo AUNG, Saw MOSES, Nigel CLARK, Guy ANDERSON, Geoff HILTON, Graeme BUCHANAN, Christoph ZÖCKLER, RE Green
Sep 28, 2018
The spoon-billed sandpiper Calidris pygmaea, a migratory arctic-breeding shorebird, is one of the world’s rarest birds and its population has undergone a large decline in recent decades. We conducted surveys at its most...
Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge.
Sonia Baig, Ehsan Parvaresh Rizi, Chelsea Chia, Muhammad Shabeer, Nweni Aung, Tze Ping Loh, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Chin Meng Khoo, Sue-Anne Toh
Oct 09, 2020
Background: Oxidative stress induced by nutritional overload has been linked to the pathogenesis of insulin resistance, which is associated with metabolic syndrome, obesity, type 2 diabetes and diabetic vascular complications....
Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds.
Tuong L Nguyen, Ye K Aung, Shuai Li, Nhut Ho Trinh, Christopher F Evans, Laura Baglietto, Kavitha Krishnan, Gillian S Dite, Jennifer Stone, Dallas R English, Yun-Mi Song, Joohon Sung, Mark A Jenkins, Melissa C Southey, Graham G Giles, John L Hopper
Feb 18, 2019
BACKGROUND: Case-control studies show that mammographic density is a better risk factor when defined at higher than conventional pixel-brightness thresholds. We asked if this applied to interval and/or screen-detected cancers....
Australian women Breast Cancer Interval cancer Mammographic density Mammography Masking effect Nested case–control cohort study Screen-detected Aged Breast Breast Density Breast Neoplasms Case-Control Studies Early Detection of Cancer Female Humans Image Processing Computer-Assisted Mammography Middle Aged Prognosis Prospective Studies Risk Assessment Risk Factors Software
Prospective association between handgrip strength and cardiac structure and function in UK adults.
Sebastian E Beyer, Mihir M Sanghvi, Nay Aung, Alice Hosking, Jackie A Cooper, José Miguel Paiva, Aaron M Lee, Kenneth Fung, Elena Lukaschuk, Valentina Carapella, Murray A Mittleman, Soren Brage, Stefan K Piechnik, Stefan Neubauer, Steffen E Petersen
Jul 20, 2018
BACKGROUND: Handgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Sue-Anne Toh
Oct 08, 2020
INTRODUCTION AND OBJECTIVE: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
A New Comprehensive Colorectal Cancer Risk Prediction Model Incorporating Family History, Personal Characteristics, and Environmental Factors.
Yingye Zheng, Xinwei Hua, Aung K Win, Robert J Macinnis, Steven Gallinger, Loic Le Marchand, Noralane M Lindor, John A Baron, John L Hopper, James G Dowty, Antonis C Antoniou, Jiayin Zheng, Mark A Jenkins, Polly A Newcomb
Feb 28, 2020
PURPOSE: Reducing colorectal cancer incidence and mortality through early detection would improve efficacy if targeted. We developed a colorectal cancer risk prediction model incorporating personal, family, genetic, and...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
Mar 14, 2020
INTRODUCTION AND OBJECTIVE:Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Oxidative Stress Adipocytes Inflammation mononuclear cells myotubes family history of type 2 diabetes
Published by: BMJ open diabetes research & care
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
Feb 10, 2020
Introduction and objective: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer.
Aung Ko Win, Mark A Jenkins, James G Dowty, Antonis C Antoniou, Andrew Lee, Graham G Giles, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Dennis J Ahnen, Stephen N Thibodeau, Graham Casey, Steven Gallinger, Loïc Le Marchand, Robert W Haile, John D Potter, Yingye Zheng, Noralane M Lindor, Polly A Newcomb, John L Hopper, Robert J Macinnis
Jan 25, 2017
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers
Costanza Paoletti, Gaia Schiavon, Emily M Dolce, Elizabeth P Darga, T Hedley Carr, Joseph Geradts, Matthias Hoch, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Shethah Morgan, Parul Patel, Vicky Rowlands, Nitharsan Sathiyayogan, Kimberly Aung, Erika Hamilton, Manish Patel, Anne Armstrong, Komal Jhaveri, Seock-Ah Im, Nadia Iqbal, Fouziah Butt, Caroline Dive, Elizabeth A Harrington, J Carl Barrett, Richard Baird, Daniel F Hayes
Nov 16, 2018
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive metastatic breast cancers include, among others, ER loss and acquired activating mutations in the ligand-binding domain of the ER...
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.
Pieter WM Bonnemaijer, Elisabeth M van Leeuwen, Adriana I Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P Khawaja, Mark Simcoe, René Höhn, Angela J Cree, Rob P Igo, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium, UK Biobank Eye and Vision Consortium, Aslihan Gerhold-Ay, Stefan Nickels, James F Wilson, Caroline Hayward, Thibaud S Boutin, Ozren Polašek, Tin Aung, Chiea Chuen Khor, Najaf Amin, Andrew J Lotery, Janey L Wiggs, Ching-Yu Cheng, Pirro G Hysi, Christopher J Hammond, Alberta AHJ Thiadens, Stuart MacGregor, Caroline CW Klaver, Cornelia M van Duijn
Nov 26, 2020
genome-wide association studies Optic Nerve Diseases Case-Control Studies Computational Biology Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Molecular Sequence Annotation Optic Disk Optic Nerve Diseases Polymorphism Single Nucleotide Quantitative Trait Loci Quantitative Trait Heritable Signal Transduction
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Sonja Neumeyer, Barbara L Banbury, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Stephanie A Bien, Dan D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Graham Casey, Andrew T Chan, Stephen J Chanock, James Y Dai, Steven Gallinger, Edward L Giovannucci, Graham G Giles, William M Grady, Jochen Hampe, Michael Hoffmeister, John L Hopper, Li Hsu, Mark A Jenkins, Amit Joshi, Susanna C Larsson, Loic Le Marchand, Annika Lindblom, Victor Moreno, Mathieu Lemire, Li Li, Yi Lin, Kenneth Offit, Polly A Newcomb, Paul D Pharaoh, John D Potter, Lihong Qi, Gad Rennert, Clemens Schafmayer, Robert E Schoen, Martha L Slattery, Mingyang Song, Cornelia M Ulrich, Aung K Win, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Stephen B Gruber, Hermann Brenner, Ulrike Peters, Jenny Chang-Claude
Jul 13, 2018
BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on...
An open dataset of <i>Plasmodium vivax</i> genome variation in 1,895 worldwide samples.
Ishag Adam, Mohammad Shafiul Alam, Sisay Alemu, Chanaki Amaratunga, Roberto Amato, Voahangy Andrianaranjaka, Nicholas M Anstey, Abraham Aseffa, Elizabeth Ashley, Ashenafi Assefa, Sarah Auburn, Bridget E Barber, Alyssa Barry, Dhelio Batista Pereira, Jun Cao, Nguyen Hoang Chau, Kesinee Chotivanich, Cindy Chu, Arjen M Dondorp, Eleanor Drury, Diego F Echeverry, Berhanu Erko, Fe Espino, Rick Fairhurst, Abdul Faiz, María Fernanda Villegas, Qi Gao, Lemu Golassa, Sonia Goncalves, Matthew J Grigg, Yaghoob Hamedi, Tran Tinh Hien, Ye Htut, Kimberly J Johnson, Nadira Karunaweera, Wasif Khan, Srivicha Krudsood, Dominic P Kwiatkowski, Marcus Lacerda, Benedikt Ley, Pharath Lim, Yaobao Liu, Alejandro Llanos-Cuentas, Chanthap Lon, Tatiana Lopera-Mesa, Jutta Marfurt, Pascal Michon, Olivo Miotto, Rezika Mohammed, Ivo Mueller, Chayadol Namaik-Larp, Paul N Newton, Thuy-Nhien Nguyen, Francois Nosten, Rintis Noviyanti, Zuleima Pava, Richard D Pearson, Beyene Petros, Aung P Phyo, Ric N Price, Sasithon Pukrittayakamee, Awab Ghulam Rahim, Milijaona Randrianarivelojosia, Julian C Rayner, Angela Rumaseb, Sasha V Siegel, Victoria J Simpson, Kamala Thriemer, Alberto Tobon-Castano, Hidayat Trimarsanto, Marcelo Urbano Ferreira, Ivan D Vélez, Sonam Wangchuk, Thomas E Wellems, Nicholas J White, Timothy William, Maria F Yasnot, Daniel Yilma
Jul 02, 2022
This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new...
Published by: Wellcome open research
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne EM Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline CW Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Sep 05, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In...
ADAMTS Proteins Asian People Cornea Corneal Diseases Corneal Dystrophies Hereditary Decorin Ehlers-Danlos Syndrome Eye Diseases Hereditary Fibrillin-1 Gene Expression Genome Human Genome-Wide Association Study Glaucoma Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait Heritable Transforming Growth Factor beta2 White People
Pf7
Muzamil Mahdi Abdel Hamid, Mohamed Hassan Abdelraheem, Desmond Omane Acheampong, Ambroise Ahouidi, Mozam Ali, Jacob Almagro-Garcia, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Ben Andagalu, Tim Anderson, Voahangy Andrianaranjaka, Ifeyinwa Aniebo, Enoch Aninagyei, Felix Ansah, Patrick O Ansah, Tobias Apinjoh, Paulo Arnaldo, Elizabeth Ashley, Sarah Auburn, Gordon A Awandare, Hampate Ba, Vito Baraka, Alyssa Barry, Philip Bejon, Gwladys I Bertin, Maciej F Boni, Steffen Borrmann, Teun Bousema, Marielle Bouyou-Akotet, Oralee Branch, Peter C Bull, Huch Cheah, Keobouphaphone Chindavongsa, Thanat Chookajorn, Kesinee Chotivanich, Antoine Claessens, David J Conway, Vladimir Corredor, Erin Courtier, Alister Craig, Umberto D'Alessandro, Souleymane Dama, Nicholas Day, Brigitte Denis, Mehul Dhorda, Mahamadou Diakite, Abdoulaye Djimde, Christiane Dolecek, Arjen Dondorp, Seydou Doumbia, Chris Drakeley, Eleanor Drury, Patrick Duffy, Diego F Echeverry, Thomas G Egwang, Sonia Maria Mauricio Enosse, Berhanu Erko, Rick M Fairhurst, Abdul Faiz, Caterina A Fanello, Mark Fleharty, Matthew Forbes, Mark Fukuda, Dionicia Gamboa, Anita Ghansah, Lemu Golassa, Sonia Goncalves, G L Abby Harrison, Sara Anne Healy, Jason A Hendry, Anastasia Hernandez-Koutoucheva, Tran Tinh Hien, Catherine A Hill, Francis Hombhanje, Amanda Hott, Ye Htut, Mazza Hussein, Mallika Imwong, Deus Ishengoma, Scott A Jackson, Chris G Jacob, Julia Jeans, Kimberly J Johnson, Claire Kamaliddin, Edwin Kamau, Jon Keatley, Theerarat Kochakarn, Drissa S Konate, Abibatou Konaté, Aminatou Kone, Dominic P Kwiatkowski, Myat P Kyaw, Dennis Kyle, Mara Lawniczak, Samuel K Lee, Martha Lemnge, Pharath Lim, Chanthap Lon, Kovana M Loua, Celine I Mandara, Jutta Marfurt, Kevin Marsh, Richard James Maude, Mayfong Mayxay, Oumou Maïga-Ascofaré, Olivo Miotto, Toshihiro Mita, Victor Mobegi, Abdelrahim Osman Mohamed, Olugbenga A Mokuolu, Jaqui Montgomery, Collins Misita Morang'a, Ivo Mueller, Kathryn Murie, Paul N Newton, Thang Ngo Duc, Thuy Nguyen, Thuy-Nhien Nguyen, Tuyen Nguyen Thi Kim, Hong Nguyen Van, Harald Noedl, Francois Nosten, Rintis Noviyanti, Vincent Ntui-Njock Ntui, Alexis Nzila, Lynette Isabella Ochola-Oyier, Harold Ocholla, Abraham Oduro, Irene Omedo, Marie A Onyamboko, Jean-Bosco Ouedraogo, Kolapo Oyebola, Wellington Aghoghovwia Oyibo, Richard Pearson, Norbert Peshu, Aung P Phyo, Christopher V Plowe, Ric N Price, Sasithon Pukrittayakamee, Huynh Hong Quang, Milijaona Randrianarivelojosia, Julian C Rayner, Pascal Ringwald, Anna Rosanas-Urgell, Eduard Rovira-Vallbona, Valentin Ruano-Rubio, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Victoria J Simpson, Mahamadou S Sissoko, Christen Smith, Xin-Zhuan Su, Colin Sutherland, Shannon Takala-Harrison, Arthur Talman, Livingstone Tavul, Ngo Viet Thanh, Vandana Thathy, Aung Myint Thu, Mahamoudou Toure, Antoinette Tshefu, Federica Verra, Joseph Vinetz, Thomas E Wellems, Jason Wendler, Nicholas J White, Georgia Whitton, William Yavo, Rob W van der Pluijm
Apr 02, 2023
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries...
Published by: Wellcome open research
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.
Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W Hewitt, Ayellet V Segrè, John M Rouhana, Andrew R Hamel, Robert P Igo, Helene Choquet, Ayub Qassim, Navya S Josyula, Jessica N Cooke Bailey, Pieter WM Bonnemaijer, Adriana Iglesias, Owen M Siggs, Terri L Young, Veronique Vitart, Alberta AHJ Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B Melles, K Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD Consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K Lupton, Nicholas G Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J Foster, Peng T Khaw, James E Morgan, Nicholas G Strouthidis, Peter Kraft, Jae H Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L Haines, Chris Hammond, Louis R Pasquale, Caroline CW Klaver, Michael Hauser, Chiea Chuen Khor, David A Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E Craig, Stuart MacGregor, Janey L Wiggs
Feb 24, 2021
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and...
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Philip J Law, Maria Timofeeva, Ceres Fernandez-Rozadilla, Peter Broderick, James Studd, Juan Fernandez-Tajes, Susan Farrington, Victoria Svinti, Claire Palles, Giulia Orlando, Amit Sud, Amy Holroyd, Steven Penegar, Evropi Theodoratou, Peter Vaughan-Shaw, Harry Campbell, Lina Zgaga, Caroline Hayward, Archie Campbell, Sarah Harris, Ian J Deary, John Starr, Laura Gatcombe, Maria Pinna, Sarah Briggs, Lynn Martin, Emma Jaeger, Archana Sharma-Oates, James East, Simon Leedham, Roland Arnold, Elaine Johnstone, Haitao Wang, David Kerr, Rachel Kerr, Tim Maughan, Richard Kaplan, Nada Al-Tassan, Kimmo Palin, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Daniel D Buchanan, Aung-Ko Win, John Hopper, Mark E Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Duggan, Graham Casey, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Douglas F Easton, Paul DP Pharoah, Julian Peto, Federico Canzian, Anthony Swerdlow, Rosalind A Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, PRACTICAL Consortium, Andrea Harkin, Karen Allan, John McQueen, James Paul, Timothy Iveson, Mark Saunders, Katja Butterbach, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Iva Kirac, Petar Matošević, Philipp Hofer, Stefanie Brezina, Andrea Gsur, Jeremy P Cheadle, Lauri A Aaltonen, Ian Tomlinson, Richard S Houlston, Malcolm G Dunlop
Jun 07, 2019
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that...
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Jennifer Wessel, Audrey Y Chu, Sara M Willems, Shuai Wang, Hanieh Yaghootkar, Jennifer A Brody, Marco Dauriz, Marie-France Hivert, Sridharan Raghavan, Leonard Lipovich, Bertha Hidalgo, Keolu Fox, Jennifer E Huffman, Ping An, Yingchang Lu, Laura J Rasmussen-Torvik, Niels Grarup, Margaret G Ehm, Li Li, Abigail S Baldridge, Alena Stančáková, Ravinder Abrol, Céline Besse, Anne Boland, Jette Bork-Jensen, Myriam Fornage, Daniel F Freitag, Melissa E Garcia, Xiuqing Guo, Kazuo Hara, Aaron Isaacs, Johanna Jakobsdottir, Leslie A Lange, Jill C Layton, Man Li, Jing Hua Zhao, Karina Meidtner, Alanna C Morrison, Mike A Nalls, Marjolein J Peters, Maria Sabater-Lleal, Claudia Schurmann, Angela Silveira, Albert V Smith, Lorraine Southam, Marcus H Stoiber, Rona J Strawbridge, Kent D Taylor, Tibor V Varga, Kristine H Allin, Najaf Amin, Jennifer L Aponte, Tin Aung, Caterina Barbieri, Nathan A Bihlmeyer, Michael Boehnke, Cristina Bombieri, Donald W Bowden, Sean M Burns, Yuning Chen, Yii-DerI Chen, Ching-Yu Cheng, Adolfo Correa, Jacek Czajkowski, Abbas Dehghan, Georg B Ehret, Gudny Eiriksdottir, Stefan A Escher, Aliki-Eleni Farmaki, Mattias Frånberg, Giovanni Gambaro, Franco Giulianini, William A Goddard, Anuj Goel, Omri Gottesman, Megan L Grove, Stefan Gustafsson, Yang Hai, Göran Hallmans, Jiyoung Heo, Per Hoffmann, Mohammad K Ikram, Richard A Jensen, Marit E Jørgensen, Torben Jørgensen, Maria Karaleftheri, Chiea C Khor, Andrea Kirkpatrick, Aldi T Kraja, Johanna Kuusisto, Ethan M Lange, IT Lee, Wen-Jane Lee, Aaron Leong, Jiemin Liao, Chunyu Liu, Yongmei Liu, Cecilia M Lindgren, Allan Linneberg, Giovanni Malerba, Vasiliki Mamakou, Eirini Marouli, Nisa M Maruthur, Angela Matchan, Roberta McKean-Cowdin, Olga McLeod, Ginger A Metcalf, Karen L Mohlke, Donna M Muzny, Ioanna Ntalla, Nicholette D Palmer, Dorota Pasko, Andreas Peter, Nigel W Rayner, Frida Renström, Ken Rice, Cinzia F Sala, Bengt Sennblad, Ioannis Serafetinidis, Jennifer A Smith, Nicole Soranzo, Elizabeth K Speliotes, Eli A Stahl, Kathleen Stirrups, Nikos Tentolouris, Anastasia Thanopoulou, Mina Torres, Michela Traglia, Emmanouil Tsafantakis, Sundas Javad, Lisa R Yanek, Eleni Zengini, Diane M Becker, Joshua C Bis, James B Brown, L Adrienne Cupples, Torben Hansen, Erik Ingelsson, Andrew J Karter, Carlos Lorenzo, Rasika A Mathias, Jill M Norris, Gina M Peloso, Wayne H-H Sheu, Daniela Toniolo, Dhananjay Vaidya, Rohit Varma, Lynne E Wagenknecht, Heiner Boeing, Erwin P Bottinger, George Dedoussis, Panos Deloukas, Ele Ferrannini, Oscar H Franco, Paul W Franks, Richard A Gibbs, Vilmundur Gudnason, Anders Hamsten, Tamara B Harris, Andrew T Hattersley, Caroline Hayward, Albert Hofman, Jan-Håkan Jansson, Claudia Langenberg, Lenore J Launer, Daniel Levy, Ben A Oostra, Christopher J O'Donnell, Stephen O'Rahilly, Sandosh Padmanabhan, James S Pankow, Ozren Polasek, Michael A Province, Stephen S Rich, Paul M Ridker, Igor Rudan, Matthias B Schulze, Blair H Smith, André G Uitterlinden, Mark Walker, Hugh Watkins, Tien Y Wong, Eleftheria Zeggini, EPIC-InterAct Consortium, Markku Laakso, Ingrid B Borecki, Daniel I Chasman, Oluf Pedersen, Bruce M Psaty, E Shyong Tai, Cornelia M van Duijn, Nicholas J Wareham, Dawn M Waterworth, Eric Boerwinkle, WH Linda Kao, Jose C Florez, Ruth JF Loos, James G Wilson, Timothy M Frayling, David S Siscovick, Josée Dupuis, Jerome I Rotter, James B Meigs, Robert A Scott, Mark O Goodarzi
Mar 24, 2015
Black People Blood Glucose Diabetes mellitus Type 2 Exome Fasting Genetic Association Studies Genetic Loci Genetic Predisposition to Disease genetic variation Glucagon-Like Peptide-1 Receptor Glucose-6-Phosphatase Humans Insulin Mutation Rate Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide White People
Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer.
Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stéphane Bézieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey, Robert J Macinnis, Peter T Campbell, Jenny Chang-Claude, Martha L Slattery, Andrew T Chan, Amit D Joshi, Mingyang Song, Yin Cao, Michael O Woods, Emily White, Stephanie J Weinstein, Cornelia M Ulrich, Michael Hoffmeister, Stephanie A Bien, Tabitha A Harrison, Jochen Hampe, Christopher I Li, Clemens Schafmayer, Kenneth Offit, Paul D Pharoah, Victor Moreno, Annika Lindblom, Alicja Wolk, Anna H Wu, Li Li, Marc J Gunter, Andrea Gsur, Temitope O Keku, Rachel Pearlman, D Timothy Bishop, Sergi Castellví-Bel, Leticia Moreira, Pavel Vodicka, Ellen Kampman, Graham G Giles, Demetrius Albanes, John A Baron, Sonja I Berndt, Stefanie Brezina, Stephan Buch, Daniel D Buchanan, Antonia Trichopoulou, Gianluca Severi, María-Dolores Chirlaque, Maria-José Sánchez, Domenico Palli, Tilman Kühn, Neil Murphy, Amanda J Cross, Andrea N Burnett-Hartman, Stephen J Chanock, Albert de la Chapelle, Douglas F Easton, Faye Elliott, Dallas R English, Edith JM Feskens, Liesel M Fitzgerald, Phyllis J Goodman, John L Hopper, Thomas J Hudson, David J Hunter, Eric J Jacobs, Corinne E Joshu, Sébastien Küry, Sanford D Markowitz, Roger L Milne, Elizabeth A Platz, Gad Rennert, Hedy S Rennert, Fredrick R Schumacher, Robert S Sandler, Daniela Seminara, Catherine M Tangen, Stephen N Thibodeau, Amanda E Toland, Franzel JB van Duijnhoven, Kala Visvanathan, Ludmila Vodickova, John D Potter, Satu Männistö, Korbinian Weigl, Jane Figueiredo, Vicente Martín, Susanna C Larsson, Patrick S Parfrey, Wen-Yi Huang, Heinz-Josef Lenz, Jose E Castelao, Manuela Gago-Dominguez, Victor Muñoz-Garzón, Christoph Mancao, Christopher A Haiman, Lynne R Wilkens, Erin Siegel, Elizabeth Barry, Ban Younghusband, Bethany Van Guelpen, Sophia Harlid, Anne Zeleniuch-Jacquotte, Peter S Liang, Mengmeng Du, Graham Casey, Noralane M Lindor, Loic Le Marchand, Steven J Gallinger, Mark A Jenkins, Polly A Newcomb, Stephen B Gruber, Robert E Schoen, Heather Hampel, Douglas A Corley, Li Hsu, Ulrike Peters, Richard B Hayes
Dec 12, 2019
BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for...
colon cancer EOCRC Penetrance SNP Age of Onset Case-Control Studies Cohort Studies Colorectal Neoplasms DNA Mutational Analysis Datasets as Topic Female Genetic Predisposition to Disease Genome-Wide Association Study Genotyping Techniques Humans Life Style Male Medical History Taking Middle Aged Mutation Rate Polymorphism Single Nucleotide Risk Factors whole genome sequencing
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