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The Drosophila anatomy ontology.
BACKGROUND: Anatomy ontologies are query-able classifications of anatomical structures. They provide a widely-used means for standardising the annotation of phenotypes and expression in both human-readable and programmatically...
Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.
Malick M Gibani, Elizabeth Jones, Amber Barton, Celina Jin, Juliette Meek, Susana Camara, Ushma Galal, Eva Heinz, Yael Rosenberg-Hasson, Gerlinde Obermoser, Claire Jones, Danielle Campbell, Charlotte Black, Helena Thomaides-Brears, Christopher Darlow, Christina Dold, Laura Silva-Reyes, Luke Blackwell, Maria Lara-Tejero, Xuyao Jiao, Gabrielle Stack, Christoph J Blohmke, Jennifer Hill, Brian Angus, Gordon Dougan, Jorge Galán, Andrew J Pollard
Jul 02, 2020
Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually1. The typhoid toxin is postulated to have a central role in disease pathogenesis, the...
Comparison of first-time microvascular decompression with percutaneous surgery for trigeminal neuralgia
OBJECTIVE: Common surgical treatments for trigeminal neuralgia (TN) include microvascular decompression (MVD) and percutaneous procedures (glycerol rhizolysis; thermocoagulation; and balloon compression). Although the efficacy...
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo JL Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Sep 15, 2020
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their...
System Dynamics Modeling Of Socioeconomic Development Mode Associated With Water Usage In Baiyangdian Lake, Northern China
With continual increase of environmental pressure from human activities, it has become necessary to study the process of socioeconomic water usage influencing the water quality. Based on the system dynamic model developed before...
Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.
Reactivation of human cytomegalovirus (HCMV) in transplant recipients can cause life-threatening disease. Consequently, for transplant recipients, killing latently infected cells could have far-reaching clinical benefits. In...
Antigens CD34 Cell Death Cells Cultured Chemokines Cytomegalovirus Disease Reservoirs Endocytosis Genes Viral Hematopoietic Stem Cell Transplantation Humans Lipopolysaccharide Receptors Monocytes Receptors Chemokine Recombinant Fusion Proteins Stem Cells Viral Load Viral Proteins Virus Activation Virus Latency
System Dynamics Modeling Of Socioeconomic Development Mode Associated With Water Usage In Baiyangdian Lake, Northern China
With continual increase of environmental pressure from human activities, it has become necessary to study the process of socioeconomic water usage influencing the water quality. Based on the system dynamic model developed before...
Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo J L Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Jul 28, 2021
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to...
Published by: Chemical science
Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels.
Acid-sensing ion channels (ASICs) are members of the diverse family of degenerin/epithelial sodium channels (DEG/ENaCs). They perform a wide range of physiological roles in healthy organisms, including in gut function and...
Higgs-mass predictions in the MSSM and beyond
P Slavich, S Heinemeyer, E Bagnaschi, H Bahl, M Goodsell, HE Haber, T Hahn, R Harlander, W Hollik, G Lee, M Mühlleitner, S Paßehr, H Rzehak, D Stöckinger, A Voigt, CEM Wagner, G Weiglein, BC Allanach, T Biekötter, S Borowka, J Braathen, M Carena, TN Dao, G Degrassi, F Domingo, P Drechsel, U Ellwanger, M Gabelmann, R Gröber, J Klappert, T Kwasnitza, D Meuser, L Mihaila, N Murphy, K Nickel, W Porod, EAR Rojas, I Sobolev, F Staub
Jul 07, 2021
Predictions for the Higgs masses are a distinctive feature of supersymmetric
extensions of the Standard Model, where they play a crucial role in
constraining the parameter space. The discovery of a Higgs boson and the
remarkably...
Common variants in breast cancer risk loci predispose to distinct tumor subtypes.
Thomas U Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L Milne, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Michael Lush, Qin Wang, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Federico Canzian, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana M Eccles, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mark S Goldberg, Anna González-Neira, Grethe I Grenaker Alnaes, Mervi Grip, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Elaine F Harkness, Bernadette AM Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Anthony Howell, ABCTB Investigators, kConFab/AOCS Investigators, Milena Jakimovska, Anna Jakubowska, Esther M John, Michael E Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N Kristensen, Ute Krüger, Katerina Kubelka-Sabit, Allison W Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J Macinnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona Mclean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G Newman, Jesse Nodora, Kenneth Offit, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Rüdiger, Emmanouil Saloustros, Sarah Sampson, Dale P Sandler, Elinor J Sawyer, Rita K Schmutzler, Minouk J Schoemaker, Ben Schöttker, Mark E Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C Southey, John J Spinelli, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Lauren R Teras, Mary Beth Terry, Diana Torres, Melissa A Troester, Celine M Vachon, Carolien HM van Deurzen, Elke M van Veen, Philippe Wagner, Clarice R Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Fergus J Couch, Jacques Simard, Peter Kraft, Douglas F Easton, Paul DP Pharoah, Marjanka K Schmidt, Montserrat García-Closas, Nilanjan Chatterjee
Feb 05, 2022
BACKGROUND: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these...
A Simultaneous Multiparametric 18F-FDG PET/MRI Radiomics Model for the Diagnosis of Triple Negative Breast Cancer.
Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Pascal AT Baltzer, Sazan Rasul, Peter Gibbs, Marcus Hacker, Ramona Woitek, Katja Pinker, Thomas H Helbich
Aug 17, 2022
PURPOSE: To investigate whether a machine learning (ML)-based radiomics model applied to 18F-FDG PET/MRI is effective in molecular subtyping of breast cancer (BC) and specifically in discriminating triple negative (TN) from...
Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.
TN Phoenix, DM Patmore, S Boop, N Boulos, MO Jacus, YT Patel, MF Roussel, D Finkelstein, L Goumnerova, S Perreault, E Wadhwa, Y-J Cho, CF Stewart, RJ Gilbertson
Mar 11, 2016
Animals Antineoplastic Agents Blood-Brain Barrier Carrier Proteins Cerebellar Neoplasms Culture Media Conditioned Disease Models Animal Drug Resistance Neoplasm Endothelium Vascular Genetic Association Studies Genetic Vectors Genotype Glucose Transporter Type 1 Humans Medulloblastoma Membrane Proteins Mice Mice Transgenic Neoplasm Proteins Paracrine Communication Pericytes Recombinant Fusion Proteins Tight Junctions Transduction Genetic Vincristine Wnt Proteins Wnt Signaling Pathway
BRCA1-like signature in triple negative breast cancer
Tesa M Severson, Justine Peeters, Ian Majewski, Magali Michaut, Astrid Bosma, Philip C Schouten, Suet-Feung Chin, Bernard Pereira, Mae A Goldgraben, Tycho Bismeijer, Roelof JC Kluin, Jettie JF Muris, Karin Jirström, Ron M Kerkhoven, Lodewyk Wessels, Carlos Caldas, René Bernards, Iris M Simon, Sabine Linn
Jul 05, 2018
Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10-15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination-mediated DNA repair and deficiency...
BRCA1 Breast Cancer Genomic Instability targeted therapy Triple negative breast cancer Adult Aged Aged 80 and over Comparative Genomic Hybridization DNA Methylation DNA Mutational Analysis Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes BRCA1 High-Throughput Nucleotide Sequencing Humans Microarray Analysis Middle Aged Molecular Targeted Therapy Promoter Regions Genetic Transcriptome Triple Negative Breast Neoplasms
Deep sequencing approach for investigating infectious agents causing fever.
TN Susilawati, AR Jex, C Cantacessi, M Pearson, S Navarro, A Susianto, AC Loukas, WJH McBride
Apr 22, 2016
A Simultaneous Multiparametric 18F-FDG PET/MRI Radiomics Model for the Diagnosis of Triple Negative Breast Cancer.
Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Pascal AT Baltzer, Sazan Rasul, Peter Gibbs, Marcus Hacker, Ramona Woitek, Katja Pinker, Thomas H Helbich
Sep 25, 2022
PURPOSE: To investigate whether a machine learning (ML)-based radiomics model applied to 18F-FDG PET/MRI is effective in molecular subtyping of breast cancer (BC) and specifically in discriminating triple negative (TN) from...
Assessing DNA methylation in the developing human intestinal epithelium
J Kraiczy, K Nayak, A Ross, T Raine, TN Mak, M Gasparetto, E Cario, V Rakyan, R Heuschkel, M Zilbauer
Jul 28, 2015
Computational tools and workflows in metabolomics
RJM Weber, TN Lawson, RM Salek, TMD Ebbels, RC Glen, R Goodacre, JL Griffin, K Haug, A Koulman, P Moreno, M Ralser, C Steinbeck, WB Dunn, MR Viant
Mar 10, 2017
This work was completed through funding provided by the BBSRC [BB/L005077/1 and BB/M019985/1] and Wellcome Trust [202952/Z/16/Z].
Fetal hydrops and the Incremental yield of Next-generation sequencing over standard prenatal Diagnostic testing (FIND) study
F Mone, RY Eberhardt, ME Hurles, DJ McMullan, ER Maher, J Lord, LS Chitty, E Dempsey, T Homfray, JL Giordano, RJ Wapner, L Sun, TN Sparks, ME Norton, MD Kilby
Oct 01, 2021
OBJECTIVE: To determine the incremental yield of exome sequencing (ES) over chromosomal microarray analysis (CMA) or karyotyping in prenatally diagnosed non-immune hydrops fetalis (NIHF). METHODS: A prospective cohort study...
Assessing the Impact of Defects on Lead-Free Perovskite-Inspired Photovoltaics via Photoinduced Current Transient Spectroscopy
V Pecunia, J Zhao, C Kim, BR Tuttle, J Mei, F Li, Y Peng, TN Huq, RLZ Hoye, ND Kelly, SE Dutton, K Xia, JL MacManus-Driscoll, H Sirringhaus
Jun 10, 2021
Smart Contracts Security Threats and Solutions
Blockchain-enabled smart contracts are subjected to several issues leading to vigorous attacks such as the decentralized autonomous organization (DAO) and the ParitySig bug on the Ethereum platform with disastrous consequences....
Published by: IGI Global Scientific Publishing
The Impact of Electronic Word-of-Mouth on the Purchase Intention of Tourists on Online Hotel Booking Applications
The study emphasizes the growing significance of electronic word-of-mouth (EWOM) in marketing, especially in service industries like tourism. Employing a research model combining the information adoption model (IAM) and the...
Published by: IGI Global Scientific Publishing
A decade of advances in transposon-insertion sequencing.
Amy K Cain, Lars Barquist, Andrew L Goodman, Ian T Paulsen, Julian Parkhill, Tim van Opijnen
Aug 04, 2020
It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS) methods, which combine genome-wide transposon mutagenesis with high-throughput sequencing to estimate the fitness contribution or...
Strongly Enhanced Photovoltaic Performance and Defect Physics of Air-Stable Bismuth Oxyiodide (BiOI)
RLZ Hoye, LC Lee, RC Kurchin, TN Huq, KHL Zhang, M Sponseller, L Nienhaus, RE Brandt, J Jean, JA Polizzotti, A Kursumović, MG Bawendi, V Bulović, V Stevanović, T Buonassisi, JL MacManus-Driscoll
Aug 23, 2017
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