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Long-Term Sustained Effect of Liver-Targeted Adeno-Associated Virus Gene Therapy for Mitochondrial Neurogastrointestinal Encephalomyopathy.
Javier Torres-Torronteras, Raquel Cabrera-Pérez, Ferran Vila-Julià, Carlo Viscomi, Yolanda Cámara, Michio Hirano, Massimo Zeviani, Ramon Martí
Jul 04, 2018
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in TYMP, the gene encoding the enzyme thymidine phosphorylase (TP). TP dysfunction results in systemic accumulation of the noxious TP...
AAV MNGIE liver/metabolic Mitochondria thymidine phosphorylase Animals Carcinogenesis Deoxyuridine Dependovirus Female Gene Dosage Genetic Therapy Genetic Vectors Intestinal Pseudo-Obstruction Kaplan-Meier Estimate Liver Male Mice Mitochondria Liver Muscular Dystrophy Oculopharyngeal Ophthalmoplegia Thymidine Thymidine Phosphorylase Time Factors Transgenes
An N-acetylglucosamine transporter required for arbuscular mycorrhizal symbioses in rice and maize
M Nadal, R Sawers, S Naseem, B Bassin, C Kulicke, A Sharman, G An, K An, KR Ahern, A Romag, TP Brutnell, C Gutjahr, N Geldner, C Roux, E Martinoia, JB Konopka, U Paszkowski
Jun 27, 2017
The Feasibility of Digitalizing Teaching Practice Through Mobile App Development
Matshidiso Taole, Zingiswa Jojo, Mogamat Davids, Michael Van Wyk, Mantsose Sethusha, Karel Prins
Jan 01, 2023
With the closure of educational institutions during COVID-19, some leadership and management teams resorted to technology for online teaching. However, for the teaching practicum (TP) module, the move to online required...
Published by: IGI Global Scientific Publishing
Texture Analysis of T1 weighted and fluid attenuated inversion recovery images detects abnormalities which correlate with disease progression in small vessel disease
Background and Purpose
MRI techniques may be useful to assess disease severity in cerebral small vessel disease (SVD), identify those individuals who are most likely to progress to dementia, monitor disease progression and act...
Retrospective evaluation of hyperproteinorrachia without pleocytosis (albuminocytologic dissociation) and survival in dogs.
BACKGROUND: Hyperproteinorrachia (raised cerebrospinal fluid total protein [CSF-TP]) without pleocytosis (HP) (also known as albuminocytologic dissociation) is identified in dogs with different neurologic diseases. However, the...
Pathogenic mtDNA mutations causing mitochondrial myopathy
Steven A Hardy, Emma L Blakely, Andrew I Purvis, Mariana C Rocha, Syeda Ahmed, Gavin Falkous, Joanna Poulton, Michael R Rose, Olivia O'Mahony, Niamh Bermingham, Charlotte F Dougan, Yi Shiau Ng, Rita Horvath, Doug M Turnbull, Grainne S Gorman, Robert W Taylor
Oct 01, 2019
Pathogenic mitochondrial tRNA (mt-tRNA) gene mutations represent a prominent cause of primary mitochondrial DNA (mtDNA)-related disease despite accounting for only 5%-10% of the mitochondrial genome.(1,2) Although some common...
Evaluating Stiffness of Fibreglass and Thermoplastic Splint Materials and Inter-fragmentary Motion in a Canine Tibial Fracture Model.
Amanda L Wagoner, Matthew J Allen, Claudia Zindl, Alan Litsky, Robert Orsher, Ron Ben-Amotz
Jun 11, 2018
OBJECTIVES: Various materials are used to construct splints for mid-diaphyseal tibial fracture stabilization. The objective of this study was to compare construct stiffness and inter-fragmentary bone motion when fibreglass (FG)...
Repeat prostate biopsy strategies after initial negative biopsy
Adam W Nelson, Rebecca C Harvey, Richard A Parker, Christof Kastner, Andrew Doble, Vincent J Gnanapragasam
Apr 17, 2020
INTRODUCTION: There is no consensus on how to investigate men with negative transrectal ultrasound guided prostate biopsy (TRUS-B) but ongoing suspicion of cancer. Three strategies used are transperineal (TP-B), transrectal...
From Face Perception to Individual Recognition: The Missing Link
Sofia Mariana Landi
Jan 01, 0001
Recognizing other individuals is a key social aspect of our everyday lives. To recognize a familiar individual, we must establish a link between sensory inputs and a representation of that individual held in memory. In primates...
Published by: Rockefeller University
Seismic excitation of offshore wind turbines and transition piece response
Expansion of the offshore wind industry in seismically active areas has raised concerns
regarding the structural integrity of offshore wind turbines under earthquake
loading. This paper details a 3D finite element study to...
Dissociating hyper- and hypoself biases to a core self-representation
Biases to favour self-related information over information related to other people have been demonstrated across a range of both high- and low-level tasks, but it is unclear whether these tasks ‘tap’ the same types of self...
Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes
Maria Pantelidou, Iztok Caglic, Anne George, Oleg Blyuss, Vincent J Gnanapragasam, Tristan Barrett
Oct 12, 2022
PURPOSE: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. METHODS: Single-centre prospective study of patients undergoing MRI for...
Rapid Alterations in Rat Brain Tryptophan Hydroxylase Activity; Effects of Adrenal Steroids, Drugs and Stressors
Efrain Charles Azmitia, Jr.
Jan 01, 0001
Tryptophan (TP) hydroxylase activity was measured using a modification of the method developed by Ichiyama et al. (l968). The distribution of the enzyme in the rat brain was determined and found to correlate with serotonin...
Published by: Rockefeller University
System Dynamics Modeling Of Socioeconomic Development Mode Associated With Water Usage In Baiyangdian Lake, Northern China
With continual increase of environmental pressure from human activities, it has become necessary to study the process of socioeconomic water usage influencing the water quality. Based on the system dynamic model developed before...
Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes
Maria Pantelidou, Iztok Caglic, Anne George, Oleg Blyuss, Vincent J Gnanapragasam, Tristan Barrett
Sep 09, 2022
PURPOSE: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. METHODS: Single-centre prospective study of patients undergoing MRI for...
This Gut Ain't Big Enough for Both of Us. Or Is It? Helminth-Microbiota Interactions in Veterinary Species
Gastrointestinal helminth parasites share their habitat with a myriad of other organisms, that is, the commensal microbiota. Increasing evidence, particularly in humans and rodent models of helminth infection, points towards a...
Maritime hominin dispersals in the Pleistocene
To what extent is there spatial and temporal patterning in the spread of our genus around the planet, and what environmental and behavioural factors specify this patterning? The prevailing model of Pleistocene dispersals of Homo...
High-Spin and Reactive Fe<sub>13</sub> Cluster with Exposed Metal Sites
Anna G. Scott, Diogo Alves Galico, Isabel Bogacz, Paul H. Oyala, Junko Yano, Elizaveta A. Suturina, Muralee Murugesu, Theodor Agapie
Dec 04, 2023
Atomically defined large metal clusters have applications in new reaction development and preparation of materials with tailored properties. Expanding the synthetic toolbox for reactive high nuclearity metal complexes, we...
Engineering polyamide nanofiltration membrane with bifunctional terpolymer brushes for antifouling and antimicrobial properties
Xinyu Zhang, Fan He, Zhe Yang, Ming Xie, Huixue Ren, Daoji Wu, Jingtao Xu, Congwei Luo, Langming Bai
Jul 15, 2023
In order to alleviate the organic/biological membrane fouling, we propose a difunctional nanofiltration membrane with integrating antifouling and antibacterial properties. In this work, the random terpolymer containing...
Antibacterial antifouling nanofiltration membrane Quaternary ammonium salts Zwitterionic moieties /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Patterning and Its Causation in the Pre-Neolithic Colonization of the Mediterranean Islands (Late Pleistocene to Early Holocene)
In 1981 one of us (Cherry) first attempted to identify spatial and temporal patterning in the human colonization of the Mediterranean islands. Since the 1980s, slowly accumulating evidence has suggested that the Mediterranean...
Holographic colour prints for enhanced optical security by combined phase and amplitude control.
Conventional optical security devices provide authentication by manipulating a specific property of light to produce a distinctive optical signature. For instance, microscopic colour prints modulate the amplitude, whereas...
Uncovering opportunities for effective species conservation banking requires navigating technical and practical complexities
Abstract: In the USA, Species Conservation Banking is a prominent example of compensatory biodiversity impact mitigation, with an annual market value estimated at US$354.2 million. Species Conservation Banking represents a...
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