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Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward...

Deep Brain Stimulation Depression Depressive Disorder Treatment-Resistant Habenula Humans Prospective Studies Quality of life Treatment Outcome

Subthalamic nucleus (STN) deep brain stimulation (DBS) can improve motor symptoms in Parkinson's disease (PD), as well as potentially improving otherwise intractable comorbid depressive symptoms. To address the latter issue, we...

Parkinson’s disease brain metabolism positron emission tomography subthalamic nucleus deep brain stimulation treatment-resistant depression

Fewer than 50% of all patients with major depressive disorder (MDD) treated with currently available antidepressants (ADs) show full remission. Moreover, about one third of the patients suffering from MDD does not respond to...

Adenosine Diphosphate Adenosine Triphosphate Adenylate Kinase Animals Antidepressive Agents antioxidants Depression Discriminant Analysis Energy Metabolism Hippocampus Ketamine Least-Squares Analysis Mice Inbred C57BL Multivariate Analysis Oxidative Phosphorylation Phosphorylation Time Factors

In coeliac disease (CeD), immune-mediated small intestinal damage is precipitated by gluten, leading to variable symptoms and complications, occasionally including aggressive T-cell lymphoma. Diagnosis, based primarily on...

T-cell receptor repertoire T-lymphocyte TRD TRG Clustering coeliac disease Duodenum gluten Machine Learning Adult Celiac disease Diet Gluten-Free Female Humans Intestine Small Machine Learning Male Middle Aged Receptors Antigen T-Cell gamma-delta

GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process...

LPS Alveolar Apoptosis Inflammation signaling Acute Lung Injury Adult Animals Cell Line Tumor Cytokine Receptor Common beta Subunit Disease Models Animal Female Gene Expression Regulation Humans Lipopolysaccharides Male Mice Mice Inbred BALB C Mice Transgenic Neutrophils Pulmonary Alveoli Receptors Granulocyte-Macrophage Colony-Stimulating Factor Time Factors

Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn's disease (CD), some of which confer susceptibility to both diseases. In order to identify...

Case-Control Studies Crohn Disease Female Gene Expression Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Polymorphism Single Nucleotide Scleroderma Systemic

BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian...

C-Reactive Protein Genome-Wide Association Study Genotype Heart Diseases Humans Immune System Diseases Mendelian Randomization Analysis Mental Disorders Metabolic Diseases Polymorphism Single Nucleotide

Abstract: Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to...

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