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Results: 102
Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology.
Christopher Barrington, Dimitra Georgopoulou, Dubravka Pezic, Wazeer Varsally, Javier Herrero, Suzana Hadjur
Jul 01, 2020
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topologically associated...
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.
Michal R Gdula, Tatyana B Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Jun 17, 2019
The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of local topologically associated domains (TADs), A/B compartments and formation of two...
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.
Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T Odom, Linda Olsson, Naveen Ravi, Eleanor L Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Jun 20, 2019
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic...
Adolescent Aneuploidy CCCTC-Binding Factor Cell Cycle Proteins Child Child Preschool Chromatin Chromosomal Proteins Non-Histone Chromosome Aberrations Core Binding Factor Alpha 2 Subunit Female Gene Dosage Gene Expression Profiling Gene Expression Regulation Leukemic Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Precursor Cell Lymphoblastic Leukemia-Lymphoma Proteogenomics Proteome Proto-Oncogene Proteins c-ets Repressor Proteins Sequence Analysis RNA Transcription Genetic
Force-reversible chemical reaction at ambient temperature for designing toughened dynamic covalent polymer networks.
Mengqi Du, Hannes A Houck, Qiang Yin, Yewei Xu, Ying Huang, Yang Lan, Li Yang, Filip E Du Prez, Guanjun Chang
Jun 09, 2022
Force-reversible C-N bonds, resulting from the click chemistry reaction between triazolinedione (TAD) and indole derivatives, offer exciting opportunities for molecular-level engineering to design materials that respond to...
Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains.
Elissavet Kentepozidou, Sarah J Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T Odom, Maša Roller, Paul Flicek
Feb 08, 2020
BACKGROUND:CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation...
Published by: Genome biology
Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains.
Elissavet Kentepozidou, Sarah J Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T Odom, Maša Roller, Paul Flicek
Jan 31, 2020
BACKGROUND: CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation...
Force-reversible chemical reaction at ambient temperature for designing toughened dynamic covalent polymer networks.
Mengqi Du, Hannes A Houck, Qiang Yin, Yewei Xu, Ying Huang, Yang Lan, Li Yang, Filip E Du Prez, Guanjun Chang
Jul 10, 2022
Force-reversible C-N bonds, resulting from the click chemistry reaction between triazolinedione (TAD) and indole derivatives, offer exciting opportunities for molecular-level engineering to design materials that respond to...
Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family
The tegumental allergen-like (TAL) proteins from Schistosoma mansoni are part of a family of calcium binding proteins found only in parasitic flatworms. These proteins have attracted interest as potential drug or vaccine...
Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.
Pamela A Lochhead, Julie A Tucker, Natalie J Tatum, Jinhua Wang, David Oxley, Andrew M Kidger, Victoria P Johnson, Megan A Cassidy, Nathanael S Gray, Martin EM Noble, Simon J Cook
May 04, 2020
The dual protein kinase-transcription factor, ERK5, is an emerging drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been developed. However, selective ERK5 kinase inhibitors fail to...
Chronic hepatosplenomegaly in African school children
Chronic hepatosplenomegaly, which is known to have a complex aetiology, is common amongst children who reside in rural areas of sub-Saharan Africa. Two of the more common infectious agents of hepatosplenomegaly amongst these...
Intergenerational Education Effects of Early Marriage in Sub-Saharan Africa
This paper analyzes the evolution of the effects on educational inequality of early marriage by looking at the impact of whether women had married young on their children’s schooling outcomes for 25–32 countries (Demographic and...
The impact of bullying on students’ learning in Latin America
We examine the impact of bullying on learning and non-cognitive outcomes for sixth grade students in 15 Latin America countries using data from the Third Regional Comparative and Explanatory Study (TERCE) learning survey. We...
Goylette F Chami, Andreas A Kontoleon, Erwin Bulte, Alan Fenwick, Narcis B Kabatereine, Edridah M Tukahebwa, David W Dunne
Sep 22, 2015
coverage mass drug administration Schistosomiasis soil-transmitted helminths Sub-Saharan Africa Adolescent Adult Albendazole Animals Anthelmintics Chemoprevention Child Disease Transmission Infectious Female Hookworm Infections Humans Male Medication Adherence Population Groups Praziquantel Rural Population Schistosomiasis Uganda
Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris.
In murine models of Schistosoma mansoni infection, egg production is associated with a switch from T helper cell (Th)1- to Th2-type responses to both schistosome-specific and unrelated antigens. Polyparasitism is common in human...
Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling.
Surgical management of pneumomediastinum in the COVID-19 patient.
As the SARS-CoV-2 virus continues to infect millions of people worldwide, the medical profession is seeing a wide range of short-term and long-term complications of COVID-19. One lesser-known complication is that of...
Precision global health and comorbidity
In low-income countries, complex comorbidities and weak health systems confound disease diagnosis and treatment. Yet, data-driven approaches have not been applied to develop better diagnostic strategies or to tailor treatment...
biosocial Global Health Networks Precision Medicine Public Health Symptoms Adolescent Adult Child Child Preschool Cluster Analysis Communicable Diseases Comorbidity Delivery of Health Care Developing Countries Female Global Health Humans Hygiene Infant Male Middle Aged Rural Population Sanitation Socioeconomic Factors Uganda Water Supply Young Adult
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