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Chimpanzees and bonobos differ in intrinsic motivation for tool use.
Tool use in nonhuman apes can help identify the conditions that drove the extraordinary expansion of hominin technology. Chimpanzees and bonobos are our closest living relatives. Whereas chimpanzees are renowned for their tool...
Modification of Service Content for Evolution of Service Platform Ecosystems
In platform ecosystems, the proper modification of goods provided could promote innovation and fulfill the need for diversity among consumers. However, most platforms in the service industry currently serve merely as...
Published by: IGI Global Scientific Publishing
Structure of the network glass-former ZnCl
Anita Zeidler, Prae Chirawatkul, Philip S. Salmon, Takeshi Usuki, Shinji Kohara, Henry E. Fischer, W. Spencer Howells
Jan 01, 2015
The structure of the network glass-forming material ZnCl was measured using both neutron and high-energy x-ray diffraction for the glass at 298(1) K and for the liquid over the temperature range 601(1)-977(2) K. Intermediate...
Sex Differences in Object Manipulation in Wild Immature Chimpanzees (Pan troglodytes schweinfurthii) and Bonobos (Pan paniscus)
Sex differences in immatures predict behavioural differences in adulthood in many mammal species. Because most studies have focused on sex differences in social interactions, little is known about possible sex differences in...
Interpretable brain age prediction using linear latent variable models of functional connectivity
Ricardo Pio Monti, Alex Gibberd, Sandipan Roy, Matt Nunes, Romy Lorenz, Robert Leech, Takeshi Ogawa, Motoaki Kawanabe, Aapo Hyvarinen
Jun 10, 2020
Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on...
Association of alcohol consumption with prevalence of fatty liver after adjustment for dietary patterns
Ryoko Tajima, Fumiaki Imamura, Takeshi Kimura, Satomi Kobayashi, Katsunori Masuda, Kaoruko Iida
Jul 24, 2019
Interpretable brain age prediction using linear latent variable models of functional connectivity
Ricardo Pio Monti, Alex Gibberd, Sandipan Roy, Matthew Nunes, Romy Lorenz, Robert Leech, Takeshi Ogawa, Motoaki Kawanabe, Aapo Hyvärinen
Jun 10, 2020
Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on...
Structure of the network glass-former ZnCl
Anita Zeidler, Prae Chirawatkul, Philip S. Salmon, Takeshi Usuki, Shinji Kohara, Henry E. Fischer, W. Spencer Howells
Jan 01, 2015
The structure of the network glass-forming material ZnCl was measured using both neutron and high-energy x-ray diffraction for the glass at 298(1) K and for the liquid over the temperature range 601(1)-977(2) K. Intermediate...
Interpretable brain age prediction using linear latent variable models of functional connectivity
Ricardo Pio Monti, Alex Gibberd, Sandipan Roy, Matt Nunes, Romy Lorenz, Robert Leech, Takeshi Ogawa, Motoaki Kawanabe, Aapo Hyvarinen
Jun 10, 2020
Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on...
Current and evolving standards of care for patients with ARDS.
Mario Menk, Elisa Estenssoro, Sarina K Sahetya, Ary Serpa Neto, Pratik Sinha, Arthur S Slutsky, Charlotte Summers, Takeshi Yoshida, Thomas Bein, Niall D Ferguson
Nov 20, 2020
Care for patients with acute respiratory distress syndrome (ARDS) has changed considerably over the 50 years since its original description. Indeed, standards of care continue to evolve as does how this clinical entity is...
Interpretable brain age prediction using linear latent variable models of functional connectivity.
Ricardo Pio Monti, Alex Gibberd, Sandipan Roy, Matthew Nunes, Romy Lorenz, Robert Leech, Takeshi Ogawa, Motoaki Kawanabe, Aapo Hyvärinen
Jul 13, 2020
Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on...
Prospective association of soft drink consumption with depressive symptoms.
Ikuko Kashino, Takeshi Kochi, Fumiaki Imamura, Masafumi Eguchi, Keisuke Kuwahara, Akiko Nanri, Kayo Kurotani, Shamima Akter, Huan Hu, Takako Miki, Isamu Kabe, Tetsuya Mizoue
May 01, 2020
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura, Ryuji Hamamoto
Jun 28, 2011
Biomarkers Tumor Carcinoma Non-Small-Cell Lung Cell Cycle Proteins Cell Line Tumor Cell Proliferation DNA-Binding Proteins Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing HCT116 Cells HEK293 Cells HeLa Cells Hep G2 Cells Humans Lung Neoplasms Minichromosome Maintenance Complex Component 7 Neoplasms Nuclear Proteins Prognosis Protein Binding Protein-Arginine N-Methyltransferases RNA Small Interfering
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis
Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I Field, John D Kelly, David E Neal, Hiroki Yamaue, Bruce AJ Ponder, Yusuke Nakamura, Ryuji Hamamoto
Sep 12, 2011
Cell Line Tumor Cell Proliferation E2F1 Transcription Factor E2F2 Transcription Factor Female Gene Expression Regulation Neoplastic Humans Jumonji Domain-Containing Histone Demethylases Male Nuclear Proteins Oligonucleotide Array Sequence Analysis Precancerous Conditions Repressor Proteins Reproducibility of Results Retinoblastoma Protein Signal Transduction Tissue Array Analysis Up-Regulation
The Amyloid-β Pathway in Alzheimer's Disease.
Harald Hampel, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi Iwatsubo, Colin L Masters, Min Cho, Lars Lannfelt, Jeffrey L Cummings, Andrea Vergallo
Jan 28, 2022
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics...
The amyloid-β pathway in Alzheimer's disease
Harald Hampel, Yan Hu, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi Iwatsubo, Colin L Masters, Min Cho, Lars Lannfelt, Jeffrey L Cummings, Andrea Vergallo
Mar 30, 2023
WHAT IS THIS SUMMARY ABOUT?: This plain language summary of an article published in Molecular Psychiatry, reviews the evidence supporting the role of the amyloid-β (Aβ) pathway and its dysregulation in Alzheimer's disease (AD)...
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Terumasa Umemoto, Keiyo Takubo, Hitoshi Takizawa, Susumu Goyama, Yasushi Ishihama, Hiroaki Honda, Berthold Göttgens, Toshio Kitamura
Dec 16, 2019
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between "dormant" and "active" HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line...
CDK G(0) phase HSC Calcium Cell Cycle dormancy Hematopoietic stem cell p27 Animals Biomarkers Calcium Cell Proliferation Cell Self Renewal Cytoplasm Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Hematopoietic Stem Cells Male Mice Mice Inbred C57BL Resting Phase Cell Cycle Single-Cell Analysis
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Evanna L Mills, Kerry A Pierce, Mark P Jedrychowski, Ryan Garrity, Sally Winther, Sara Vidoni, Takeshi Yoneshiro, Jessica B Spinelli, Gina Z Lu, Lawrence Kazak, Alexander S Banks, Marcia C Haigis, Shingo Kajimura, Michael P Murphy, Steven P Gygi, Clary B Clish, Edward T Chouchani
Oct 10, 2018
Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease1. Thermogenic respiration is initiated by adipocyte lipolysis through cyclic AMP-protein kinase A...
Alternatives to Student Outbound Mobility-Improving Students' Cultural Competency Skills Online to Improve Global Health Without Travel.
Anette Wu, Vinay Maddula, Jasmine Singh, Mandeep Gill Sagoo, Chung-Liang Chien, Richard Wingate, Heike Kielstein, Hannes Traxler, Cecilia Brassett, Jens Waschke, Fransziska Vielmuth, Takeshi Sakurai, Mina Zeroual, Jorgen Olsen, Salma El-Batti, Suvi Viranta-Kovanen, Shuji Kitahara, Kevin Keay, Carol Kunzel, Paulette Bernd, Geoffroy PJC Noël
Jul 28, 2021
INTRODUCTION: Student outbound mobility is a major element in internationalization of medical education and global health education. However, this approach is often criticized, as it is inherently inequitable....
IFPA meeting 2018 workshop report II
Christiane Albrecht, Larry Chamley, D Stephen Charnock-Jones, Sally Collins, Hiroshi Fujiwara, Thaddeus Golos, Solene Grayo, Natalie Hannan, Lynda Harris, Kiyotake Ichizuka, Nicholas P Illsley, Mitsutoshi Iwashita, Sampada Kallol, Abdulla Al-Khan, Gendie Lash, Takeshi Nagamatsu, Akitoshi Nakashima, Kaoru Niimi, Masataka Nomoto, Christopher Redman, Shigeru Saito, Kenji Tanimura, Masatoshi Tomi, Hirokazu Usui, Manu Vatish, Bryce Wolfe, Eiko Yamamoto, Perrie O'Tierney-Ginn
Mar 25, 2019
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops...
Abnormally invasive placenta Drug delivery Gestational trophoblastic disease Infection Preeclampsia Animals Biomedical Research Drug Delivery Systems Education Female Gestational Trophoblastic Disease gynecology History 21st Century Humans Inflammation Japan Obstetrics Placenta Placenta Diseases pre-eclampsia Pregnancy Pregnancy Complications Infectious Societies Medical
Paleomagnetism. Solar nebula magnetic fields recorded in the Semarkona meteorite.
YAP is essential for tissue tension to ensure vertebrate 3D body shape
Sean Porazinski, Huijia Wang, Yoichi Asaoka, Martin Behrndt, Tatsuo Miyamoto, Hitoshi Morita, Shoji Hata, Takashi Sasaki, S. F Gabriel Krens, Yumi Osada, Satoshi Asaka, Akihiro Momoi, Sarah Linton, Joel B. Miesfeld, Brian A. Link, Takeshi Senga, Atahualpa Castillo-Morales, Araxi O. Urrutia, Nobuyoshi Shimizu, Hideaki Nagase, Shinya Matsuura, Stefan Bagby, Hisato Kondoh, Hiroshi Nishina, Carl Philipp Heisenberg, Makoto Furutani-Seiki
May 14, 2015
Vertebrates have a unique 3D body shape in which correct tissue and organ shape and alignment are essential for function. For example, vision requires the lens to be centred in the eye cup which must in turn be correctly...
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