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Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.
Monte Carlo simulations of a mesoscale model of oligonucleosomes are analyzed to examine the role of dynamic-linker histone (LH) binding/unbinding in high monovalent salt with divalent ions, and to further interpret noted...
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Perceived Diagnostic Uncertainty in Pediatric Chronic Pain
In this review, we argue that perceived diagnostic uncertainty in idiopathic pediatric chronic pain patients and their parents is critically important for understanding pain cognitions, behavioral responses to pain, treatment...
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Perceived Diagnostic Uncertainty in Pediatric Chronic Pain
In this review, we argue that perceived diagnostic uncertainty in idiopathic pediatric chronic pain patients and their parents is critically important for understanding pain cognitions, behavioral responses to pain, treatment...
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Diagnostic uncertainty in youth with chronic pain and their parents

Diagnostic uncertainty—the perception of a lack of or incorrect label to explain symptoms—has been reported by parents of youth with chronic pain. This study was the first to examine diagnostic uncertainty in both youth with...

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A Method for Rapid Ethical Deliberation in Research and Innovation Projects
There are many and diverse methods available that can help researchers, designers, developers, and engineers integrate ethics in their research and innovation projects. In practice, however, they can find this challenging. They...
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure.
The basic and intrinsically disordered C-terminal domain (CTD) of the linker histone (LH) is essential for chromatin compaction. However, its conformation upon nucleosome binding and its impact on chromatin organization remain...
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Diagnostic uncertainty in pediatric chronic pain
Introduction: Diagnostic uncertainty (DU), which is the perception that a label or explanation for a patient’s health problem is missing or inaccurate, has been linked to distress, anxiety, and difficulty coping among adults...
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Diagnostic uncertainty in youth with chronic pain and their parents

Diagnostic uncertainty—the perception of a lack of or incorrect label to explain symptoms—has been reported by parents of youth with chronic pain. This study was the first to examine diagnostic uncertainty in both youth with...

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Drawing a line in the sand’
Background: Diagnostic uncertainty is the subjective perception of an inability to provide an accurate explanation of the patient’s health problem or that a label is missing or incorrect. While recently explored in youth with...
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Drawing a line in the sand’
Background: Diagnostic uncertainty is the subjective perception of an inability to provide an accurate explanation of the patient’s health problem or that a label is missing or incorrect. While recently explored in youth with...
Published by:
Diagnostic uncertainty in pediatric chronic pain
Introduction: Diagnostic uncertainty (DU), which is the perception that a label or explanation for a patient’s health problem is missing or inaccurate, has been linked to distress, anxiety, and difficulty coping among adults...
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Complex pattern of facial remapping in somatosensory cortex following congenital but not acquired hand loss.
Cortical remapping after hand loss in the primary somatosensory cortex (S1) is thought to be predominantly dictated by cortical proximity, with adjacent body parts remapping into the deprived area. Traditionally, this remapping...
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Antidepressants for pain management in adults with chronic pain

Background: Chronic pain is common in adults, and often has a detrimental impact upon physical ability, well-being, and quality of life. Previous reviews have shown that certain antidepressants may be effective in reducing...

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Antidepressants for pain management in adults with chronic pain

Background: Chronic pain is common in adults, and often has a detrimental impact upon physical ability, well-being, and quality of life. Previous reviews have shown that certain antidepressants may be effective in reducing...

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Rapid metal pollutant deposition from the volcanic plume of Kīlauea, Hawai’i
Abstract: Long-lived basaltic volcanic eruptions are a globally important source of environmentally reactive, volatile metal pollutant elements such as selenium, cadmium and lead. The 2018 eruption of Kīlauea, Hawai’i produced...
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Rapid metal pollutant deposition from the volcanic plume of Kīlauea, Hawai’i
Abstract: Long-lived basaltic volcanic eruptions are a globally important source of environmentally reactive, volatile metal pollutant elements such as selenium, cadmium and lead. The 2018 eruption of Kīlauea, Hawai’i produced...
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