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Endowment of Scholarship Honors Late Alumna Anna Marie Hurst '12
Winthrop University
Jan 01, 0001
The Anna Marie Hurst Memorial Scholarship supports students majoring in elementary education, early childhood education or family and consumer sciences. Hurst, a native of Rock Hill, earned her B.S. in family and consumer...
Published by: Winthrop University
Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer Patients.
Leila Jahangiri, Tara Hurst
Dec 05, 2019
Somatic alterations to the genomes of solid tumours, which in some cases represent actionable drivers, provide diagnostic and prognostic insight into these complex diseases. Spatial and longitudinal tracking of somatic genomic...
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Senior Dies Suddenly Day Before Commencement Ceremony
Winthrop University
Jan 01, 0001
The passing of Anna Marie Hurst, a family and consumer sciences major from Rock Hill, S.C., will be acknowledged during the event at Winthrop Coliseum. Anna Hurst was home with her family last night helping to trim their...
Published by: Winthrop University
Beloved Winthrop Student Veterans Association Member Passes Away
Winthrop University
Jan 01, 0001
Tara Sims, of Fort Mill, was a senior studying business administration. She was a beloved member of the Student Veterans Association.
Published by: Winthrop University
Funerals against death
Tara Bailey, Tony Walter
Jan 01, 0001
While anthropological studies in non-Western societies show how funerals protect the community from the threat of death, sociological studies of British funerals have so far focused on meanings for the private family. The...
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Funerals against death
Tara Bailey, Tony Walter
Jan 01, 0001
While anthropological studies in non-Western societies show how funerals protect the community from the threat of death, sociological studies of British funerals have so far focused on meanings for the private family. The...
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A century of bias in genetics and evolution
Laurence Hurst
Jun 12, 2019

Mendel proposed that the heritable material is particulate and that transmission of alleles is unbiased. An assumption of unbiased transmission was necessary to show how variation can be preserved in the absence of selection...

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Purifying selection on exonic splice enhancers in intronless genes
Exonic splice enhancers (ESEs) are short nucleotide motifs, enriched near exon ends, that enhance the recognition of the splice site and thus promote splicing. Are intronless genes under selection to avoid these motifs so as not...
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A century of bias in genetics and evolution
Laurence Hurst
Jun 12, 2019

Mendel proposed that the heritable material is particulate and that transmission of alleles is unbiased. An assumption of unbiased transmission was necessary to show how variation can be preserved in the absence of selection...

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Why selection might be stronger when populations are small
The nearly-neutral theory predicts that small effective population size provides the conditions for weakened selection. This is postulated to explain why our genome is more “bloated” than that of, for example, yeast, ours having...
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Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp
In the great majority of genomes, the use of positive charge increases, on average, approaching protein N-termini. Such charged residues slow ribosomes by interacting with the negatively charged exit tunnel. This has been...
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Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution
While the principal force directing coding sequence (CDS) evolution is selection on protein function, to ensure correct gene expression CDSs must also maintain interactions with RNA-binding proteins (RBPs). Understanding how our...
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Error prevention and mitigation as forces in the evolution of genes and genomes
Why are short introns rarely a multiple of three nucleotides long? Why do essential genes cluster? Why are genes in operons often lined up in the order in which they are needed in the encoded pathway? In this Opinion article, we...
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Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster
Recent evidence suggests that germline transcription may affect both protein evolutionary rates, possibly mediated by repair processes, and recombination rates, possibly mediated by chromatin and epigenetic modification. Here...
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Panel manipulation in social stress testing
Background

Whilst acute stress paradigms in adults make use of adult panel members, similar paradigms modified for child participants have not manipulated the panel. Most work has utilised an audience of adult...
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GroEL dependency affects codon usage-support for a critical role of misfolding in gene evolution
T Warnecke, L D Hurst
Jan 19, 2010
It has recently been suggested that the use of optimal codons limits mistranslation-induced protein misfolding, yet evidence for this remains largely circumstantial. In contrast, molecular chaperones have long been recognized to...
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Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster
Recent evidence suggests that germline transcription may affect both protein evolutionary rates, possibly mediated by repair processes, and recombination rates, possibly mediated by chromatin and epigenetic modification. Here...
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Determinants of the usage of splice-associated<i> cis</i>-motifs predict the distribution of human pathogenic SNPs
Where in genes do pathogenic mutations tend to occur and does this provide clues as to the possible underlying mechanisms by which single nucleotide polymorphisms (SNPs) cause disease? As splice-disrupting mutations tend to...
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