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Results: 55
Novel flaviviruses from mosquitoes
Eili Huhtamo, Shelley Cook, Gregory Moureau, Nathalie Y Uzcátegui, Tarja Sironen, Suvi Kuivanen, Niina Putkuri, Satu Kurkela, Ralph E Harbach, Andrew E Firth, Olli Vapalahti, Ernest A Gould, Xavier de Lamballerie
Apr 27, 2015
Making Waves
Lian Lundy, Despo Fatta-Kassinos, Jaroslav Slobodnik, Popi Karaolia, Lubos Cirka, Norbert Kreuzinger, Sara Castiglioni, Lubertus Bijlsma, Valeria Dulio, Geneviève Deviller, Foon Yin Lai, Nikiforos Alygizakis, Manuela Barneo, Jose Antonio Baz-Lomba, Frederic Béen, Marianna Cíchová, Kelly Conde-Pérez, Adrian Covaci, Erica Donner, Andrej Ficek, Francis Hassard, Annelie Hedström, Félix Hernandez, Veronika Janská, Kristen Jellison, Jan Hofman, Kelly Hill, Pei Ying Hong, Barbara Kasprzyk-Hordern, Stoimir Kolarević, Jan Krahulec, Dimitra Lambropoulou, Rosa de Llanos, Tomáš Mackuľak, Lorena Martinez-García, Francisco Martínez, Gertjan Medema, Adrienn Micsinai, Mette Myrmel, Mohammed Nasser, Harald Niederstätter, Leonor Nozal, Herbert Oberacher, Věra Očenášková, Leslie Ogorzaly, Dimitrios Papadopoulos, Beatriz Peinado, Tarja Pitkänen, Margarita Poza, Soraya Rumbo-Feal, Maria Blanca Sánchez, Anna J. Székely, Andrea Soltysova, Nikolaos S. Thomaidis, Juan Vallejo, Alexander van Nuijs, Vassie Ware, Maria Viklander
Jul 01, 2021
The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. Over the subsequent months, the potential for wastewater surveillance to contribute to COVID-19 mitigation programmes has been the focus of...
/dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2300/2302 name=Ecological Modelling /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Making Waves
Lian Lundy, Despo Fatta-Kassinos, Jaroslav Slobodnik, Popi Karaolia, Lubos Cirka, Norbert Kreuzinger, Sara Castiglioni, Lubertus Bijlsma, Valeria Dulio, Geneviève Deviller, Foon Yin Lai, Nikiforos Alygizakis, Manuela Barneo, Jose Antonio Baz-Lomba, Frederic Béen, Marianna Cíchová, Kelly Conde-Pérez, Adrian Covaci, Erica Donner, Andrej Ficek, Francis Hassard, Annelie Hedström, Félix Hernandez, Veronika Janská, Kristen Jellison, Jan Hofman, Kelly Hill, Pei Ying Hong, Barbara Kasprzyk-Hordern, Stoimir Kolarević, Jan Krahulec, Dimitra Lambropoulou, Rosa de Llanos, Tomáš Mackuľak, Lorena Martinez-García, Francisco Martínez, Gertjan Medema, Adrienn Micsinai, Mette Myrmel, Mohammed Nasser, Harald Niederstätter, Leonor Nozal, Herbert Oberacher, Věra Očenášková, Leslie Ogorzaly, Dimitrios Papadopoulos, Beatriz Peinado, Tarja Pitkänen, Margarita Poza, Soraya Rumbo-Feal, Maria Blanca Sánchez, Anna J. Székely, Andrea Soltysova, Nikolaos S. Thomaidis, Juan Vallejo, Alexander van Nuijs, Vassie Ware, Maria Viklander
Jul 01, 2021
The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. Over the subsequent months, the potential for wastewater surveillance to contribute to COVID-19 mitigation programmes has been the focus of...
/dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2300/2302 name=Ecological Modelling /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
Oct 04, 2019
GWAS blood cell traits cardiometabolic diseases colocalisation analysis Cytokines eQTLs metabolites Multivariate Analysis protein QTLs Adolescent Adult Aged Biomarkers Blood Proteins Cardiovascular Diseases Child Cytokines Female Follow-Up Studies Gene Regulatory Networks Genetic Pleiotropy Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Prognosis Prospective Studies Quantitative Trait Loci Young Adult
Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer.
Johanna Kondelin, Kari Salokas, Lilli Saarinen, Kristian Ovaska, Heli Rauanheimo, Roosa-Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, Alexandra E Gylfe, Tatiana Cajuso, Ulrika A Hänninen, Kimmo Palin, Heikki Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, Mervi Aavikko, Minna Taipale, Jussi Taipale, Laura Renkonen-Sinisalo, Anna Lepistö, Selja Koskensalo, Jan Böhm, Jukka-Pekka Mecklin, Halit Ongen, Emmanouil T Dermitzakis, Outi Kilpivaara, Pia Vahteristo, Mikko Turunen, Sampsa Hautaniemi, Sari Tuupanen, Auli Karhu, Niko Välimäki, Markku Varjosalo, Esa Pitkänen, Lauri A Aaltonen
Jun 05, 2019
Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Jun 06, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The future of zoonotic risk prediction
Colin J. Carlson, Maxwell J. Farrell, Zoe Grange, Barbara A. Han, Nardus Mollentze, Alexandra L. Phelan, Angela L. Rasmussen, Gregory F. Albery, Bernard Bett, David M. Brett-Major, Lily E. Cohen, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Kristian M. Forbes, Rory Gibb, Sam Halabi, Charlotte C. Hammer, Rebecca Katz, Jason Kindrachuk, Renata L. Muylaert, Felicia B. Nutter, Joseph Ogola, Kevin J. Olival, Michelle Rourke, Sadie J. Ryan, Noam Ross, Stephanie N. Seifert, Tarja Sironen, Claire J. Standley, Kishana Taylor, Marietjie Venter, Paul W. Webala
Sep 23, 2021
In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat...
The future of zoonotic risk prediction.
Colin J Carlson, Maxwell J Farrell, Zoe Grange, Barbara A Han, Nardus Mollentze, Alexandra L Phelan, Angela L Rasmussen, Gregory F Albery, Bernard Bett, David M Brett-Major, Lily E Cohen, Tad Dallas, Evan A Eskew, Anna C Fagre, Kristian M Forbes, Rory Gibb, Sam Halabi, Charlotte C Hammer, Rebecca Katz, Jason Kindrachuk, Renata L Muylaert, Felicia B Nutter, Joseph Ogola, Kevin J Olival, Michelle Rourke, Sadie J Ryan, Noam Ross, Stephanie N Seifert, Tarja Sironen, Claire J Standley, Kishana Taylor, Marietjie Venter, Paul W Webala
Oct 21, 2021
In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Dec 04, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W. Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N. Giordano, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T. Dermitzakis, Ian M. Forgie, Gary Frost, Torben Hansen, Tue H. Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J. McDonald, Oluf Pedersen, Femke Rutters, Jochen M. Schwenk, Harriet J. A. Teare, E. Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W. Franks
Nov 13, 2020
Abstract: Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed...
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes
Robert W Koivula, Naeimeh Atabaki-Pasdar, Giuseppe N Giordano, Tom White, Jerzy Adamski, Jimmy D Bell, Joline Beulens, Søren Brage, Søren Brunak, Federico De Masi, Emmanouil T Dermitzakis, Ian M Forgie, Gary Frost, Torben Hansen, Tue H Hansen, Andrew Hattersley, Tarja Kokkola, Azra Kurbasic, Markku Laakso, Andrea Mari, Timothy J McDonald, Oluf Pedersen, Femke Rutters, Jochen M Schwenk, Harriet JA Teare, E Louise Thomas, Ana Vinuela, Anubha Mahajan, Mark I McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Imre Pavo, Paul W Franks, IMI DIRECT Consortium
Jan 29, 2021
Beta cell function ectopic fat glycaemic control insulin sensitivity physical activity Prediabetes structural equation modelling Type 2 diabetes Aged Blood Glucose Cohort Studies Cross-Sectional Studies Denmark Diabetes mellitus Type 2 Energy Metabolism Exercise Female Finland Glucose Tolerance Test glycemic control Homeostasis Humans Insulin Resistance Male Middle Aged Netherlands Sweden
The future of zoonotic risk prediction
Colin J. Carlson, Maxwell J. Farrell, Zoe Grange, Barbara A. Han, Nardus Mollentze, Alexandra L. Phelan, Angela L. Rasmussen, Gregory F. Albery, Bernard Bett, David M. Brett-Major, Lily E. Cohen, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Kristian M. Forbes, Rory Gibb, Sam Halabi, Charlotte C. Hammer, Rebecca Katz, Jason Kindrachuk, Renata L. Muylaert, Felicia B. Nutter, Joseph Ogola, Kevin J. Olival, Michelle Rourke, Sadie J. Ryan, Noam Ross, Stephanie N. Seifert, Tarja Sironen, Claire J. Standley, Kishana Taylor, Marietjie Venter, Paul W. Webala
Sep 20, 2021
In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat...
Position paper on screening for breast cancer by the European Society of Breast Imaging (EUSOBI) and 30 national breast radiology bodies from Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Israel, Lithuania, Moldova, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Spain, Sweden, Switzerland and Turkey.
Francesco Sardanelli, Hildegunn S Aase, Marina Álvarez, Edward Azavedo, Henk J Baarslag, Corinne Balleyguier, Pascal A Baltzer, Vanesa Beslagic, Ulrich Bick, Dragana Bogdanovic-Stojanovic, Ruta Briediene, Boris Brkljacic, Julia Camps Herrero, Catherine Colin, Eleanor Cornford, Jan Danes, Gérard de Geer, Gul Esen, Andrew Evans, Michael H Fuchsjaeger, Fiona J Gilbert, Oswald Graf, Gormlaith Hargaden, Thomas H Helbich, Sylvia H Heywang-Köbrunner, Valentin Ivanov, Ásbjörn Jónsson, Christiane K Kuhl, Eugenia C Lisencu, Elzbieta Luczynska, Ritse M Mann, Jose C Marques, Laura Martincich, Margarete Mortier, Markus Müller-Schimpfle, Katalin Ormandi, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Katja Pinker, Tarja Rissanen, Natalia Rotaru, Gianni Saguatti, Tamar Sella, Jana Slobodníková, Maret Talk, Patrice Taourel, Rubina M Trimboli, Ilse Vejborg, Athina Vourtsis, Gabor Forrai
Nov 25, 2016
UNLABELLED: EUSOBI and 30 national breast radiology bodies support mammography for population-based screening, demonstrated to reduce breast cancer (BC) mortality and treatment impact. According to the International Agency for...
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk
Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Aug 01, 2020
Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free...
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk
Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Aug 01, 2020
Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free...
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
Danielle E Haslam, Gina M Peloso, Melanie Guirette, Fumiaki Imamura, Traci M Bartz, Achilleas N Pitsillides, Carol A Wang, Ruifang Li-Gao, Jason M Westra, Niina Pitkänen, Kristin L Young, Mariaelisa Graff, Alexis C Wood, Kim VE Braun, Jian'an Luan, Mika Kähönen, Jessica C Kiefte-de Jong, Mohsen Ghanbari, Nathan Tintle, Rozenn N Lemaitre, Dennis O Mook-Kanamori, Kari North, Mika Helminen, Yasmin Mossavar-Rahmani, Linda Snetselaar, Lisa W Martin, Jorma S Viikari, Wendy H Oddy, Craig E Pennell, Frits R Rosendall, M Arfan Ikram, Andre G Uitterlinden, Bruce M Psaty, Dariush Mozaffarian, Jerome I Rotter, Kent D Taylor, Terho Lehtimäki, Olli T Raitakari, Kara A Livingston, Trudy Voortman, Nita G Forouhi, Nick J Wareham, Renée de Mutsert, Steven S Rich, JoAnn E Manson, Samia Mora, Paul M Ridker, Jordi Merino, James B Meigs, Hassan S Dashti, Daniel I Chasman, Alice H Lichtenstein, Caren E Smith, Josée Dupuis, Mark A Herman, Nicola M McKeown
Jul 20, 2021
BACKGROUND: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have...
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes
Robert W Koivula, Ian M Forgie, Azra Kurbasic, Ana Viñuela, Alison Heggie, Giuseppe N Giordano, Tue H Hansen, Michelle Hudson, Anitra DM Koopman, Femke Rutters, Maritta Siloaho, Kristine H Allin, Søren Brage, Caroline A Brorsson, Adem Y Dawed, Federico De Masi, Christopher J Groves, Tarja Kokkola, Anubha Mahajan, Mandy H Perry, Simone P Rauh, Martin Ridderstråle, Harriet JA Teare, E Louise Thomas, Andrea Tura, Henrik Vestergaard, Tom White, Jerzy Adamski, Jimmy D Bell, Joline W Beulens, Søren Brunak, Emmanouil T Dermitzakis, Philippe Froguel, Gary Frost, Ramneek Gupta, Torben Hansen, Andrew Hattersley, Bernd Jablonka, Jane Kaye, Markku Laakso, Timothy J McDonald, Oluf Pedersen, Jochen M Schwenk, Imre Pavo, Andrea Mari, Mark I McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Paul W Franks, IMI DIRECT Consortium
Apr 26, 2019
AIMS/HYPOTHESIS: Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 and...
Diet ectopic fat Genome glycaemic control Insulin Secretion insulin sensitivity Personalised medicine physical activity Prediabetes Type 2 diabetes Aged Biomarkers Blood Glucose Cohort Studies Diabetes mellitus Type 2 Female Glucose Glucose Tolerance Test Humans Male Metformin Middle Aged Prediabetic State Prospective Studies
The future of zoonotic risk prediction
Colin J. Carlson, Maxwell J. Farrell, Zoe Grange, Barbara A. Han, Nardus Mollentze, Alexandra L. Phelan, Angela L. Rasmussen, Gregory F. Albery, Bernard Bett, David M. Brett-Major, Lily E. Cohen, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Kristian M. Forbes, Rory Gibb, Sam Halabi, Charlotte C. Hammer, Rebecca Katz, Jason Kindrachuk, Renata L. Muylaert, Felicia B. Nutter, Joseph Ogola, Kevin J. Olival, Michelle Rourke, Sadie J. Ryan, Noam Ross, Stephanie N. Seifert, Tarja Sironen, Claire J. Standley, Kishana Taylor, Marietjie Venter, Paul W. Webala
Sep 20, 2021
In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat...
The population history of northeastern Siberia since the Pleistocene.
Martin Sikora, Vladimir V Pitulko, Vitor C Sousa, Morten E Allentoft, Lasse Vinner, Simon Rasmussen, Ashot Margaryan, Peter de Barros Damgaard, Constanza de la Fuente, Gabriel Renaud, Melinda A Yang, Qiaomei Fu, Isabelle Dupanloup, Konstantinos Giampoudakis, David Nogués-Bravo, Carsten Rahbek, Guus Kroonen, Michaël Peyrot, Hugh McColl, Sergey V Vasilyev, Elizaveta Veselovskaya, Margarita Gerasimova, Elena Y Pavlova, Vyacheslav G Chasnyk, Pavel A Nikolskiy, Andrei V Gromov, Valeriy I Khartanovich, Vyacheslav Moiseyev, Pavel S Grebenyuk, Alexander Yu Fedorchenko, Alexander I Lebedintsev, Sergey B Slobodin, Boris A Malyarchuk, Rui Martiniano, Morten Meldgaard, Laura Arppe, Jukka U Palo, Tarja Sundell, Kristiina Mannermaa, Mikko Putkonen, Verner Alexandersen, Charlotte Primeau, Nurbol Baimukhanov, Ripan S Malhi, Karl-Göran Sjögren, Kristian Kristiansen, Anna Wessman, Antti Sajantila, Marta Mirazon Lahr, Richard Durbin, Rasmus Nielsen, David J Meltzer, Laurent Excoffier, Eske Willerslev
Nov 05, 2020
Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through...
Contribution of allelic imbalance to colorectal cancer.
Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A Aaltonen
Jun 04, 2019
Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in...
Allelic Imbalance CRISPR-Cas Systems Chromosome Aberrations Chromosomes Human Pair 8 Colorectal Neoplasms DNA Copy Number Variations Denmark Gene Expression Profiling Genetic Predisposition to Disease Genomics Genotype Humans Loss of Heterozygosity Microsatellite Repeats Phenotype Point Mutation Proto-Oncogene Proteins p21(ras) RNA Small Interfering Transcription Factors Tumor Suppressor Protein p53 whole genome sequencing
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes
Robert W. Koivula, Ian M. Forgie, Azra Kurbasic, Ana Viñuela, Alison Heggie, Giuseppe N. Giordano, Tue H. Hansen, Michelle Hudson, Anitra D. M. Koopman, Femke Rutters, Maritta Siloaho, Kristine H. Allin, Søren Brage, Caroline A. Brorsson, Adem Y. Dawed, Federico De Masi, Christopher J. Groves, Tarja Kokkola, Anubha Mahajan, Mandy H. Perry, Simone P. Rauh, Martin Ridderstråle, Harriet J. A. Teare, E. Louise Thomas, Andrea Tura, Henrik Vestergaard, Tom White, Jerzy Adamski, Jimmy D. Bell, Joline W. Beulens, Søren Brunak, Emmanouil T. Dermitzakis, Philippe Froguel, Gary Frost, Ramneek Gupta, Torben Hansen, Andrew Hattersley, Bernd Jablonka, Jane Kaye, Markku Laakso, Timothy J. McDonald, Oluf Pedersen, Jochen M. Schwenk, Imre Pavo, Andrea Mari, Mark I. McCarthy, Hartmut Ruetten, Mark Walker, Ewan Pearson, Paul W. Franks
Jun 15, 2020
Abstract: Aims/hypothesis: Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations...
Predicting and elucidating the etiology of fatty liver disease
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G. Jones, E. Louise Thomas, Robert W. Koivula, Azra Kurbasic, Pascal M. Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y. Dawed, Giuseppe N. Giordano, Ian M. Forgie, Timothy J. McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H. Allin, Tue H. Hansen, Alison Heggie, Mun-Gwan Hong, Petra J. M. Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S. Häussler, Sapna Sharma, Henrik S. Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M. ‘t Hart, Jerzy Adamski, Petra B. Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T. Hattersley, Mark Walker, Joline W. J. Beulens, Andrea Mari, Jochen M. Schwenk, Ramneek Gupta, Mark I. McCarthy, Ewan R. Pearson, Jimmy D. Bell, Imre Pavo, Paul W. Franks
Jun 19, 2020
Predicting and elucidating the etiology of fatty liver disease
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra JM Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline WJ Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks
Jun 09, 2020
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help...
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan Hong, Petra B Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe Muilwijk, Marieke T Blom, Leen M 't Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstråle, Mark Walker, Ian Forgie, Giuseppe N Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil Dermitzakis, Paul W Franks, Jochen M Schwenk, Jerzy Adamski, Mark I McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Søren Brunak, IMI DIRECT Consortium
Mar 16, 2023
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of...
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Suzanne Vogelezang, Jonathan P. Bradfield, Tarunveer S. Ahluwalia, John A. Curtin, Timo A. Lakka, Niels Grarup, Markus Scholz, Peter J. van der Most, Claire Monnereau, Evie Stergiakouli, Anni Heiskala, Momoko Horikoshi, Iryna O. Fedko, Natalia Vilor-Tejedor, Diana L. Cousminer, Marie Standl, Carol A. Wang, Jorma Viikari, Frank Geller, Carmen Íñiguez, Niina Pitkänen, Alessandra Chesi, Jonas Bacelis, Loic Yengo, Maties Torrent, Ioanna Ntalla, Øyvind Helgeland, Saskia Selzam, Judith M. Vonk, Mohammed H. Zafarmand, Barbara Heude, Ismaa Sadaf Farooqi, Akram Alyass, Robin N. Beaumont, Christian T. Have, Peter Rzehak, Jose Ramon Bilbao, Theresia M. Schnurr, Inês Barroso, Klaus Bønnelykke, Lawrence J. Beilin, Lisbeth Carstensen, Marie-Aline Charles, Bo Chawes, Karine Clément, Ricardo Closa-Monasterolo, Adnan Custovic, Johan G. Eriksson, Joaquin Escribano, Maria Groen-Blokhuis, Veit Grote, Dariusz Gruszfeld, Hakon Hakonarson, Torben Hansen, Andrew T. Hattersley, Mette Hollensted, Jouke-Jan Hottenga, Elina Hyppönen, Stefan Johansson, Raimo Joro, Mika Kähönen, Ville Karhunen, Wieland Kiess, Bridget A. Knight, Berthold Koletzko, Andreas Kühnapfel, Kathrin Landgraf, Jean-Paul Langhendries, Terho Lehtimäki, Jaakko T. Leinonen, Aihuali Li, Virpi Lindi, Estelle Lowry, Mariona Bustamante, Carolina Medina-Gomez, Mads Melbye, Kim F. Michaelsen, Camilla S. Morgen, Trevor A. Mori, Tenna R. H. Nielsen, Harri Niinikoski, Albertine J. Oldehinkel, Katja Pahkala, Kalliope Panoutsopoulou, Oluf Pedersen, Craig E. Pennell, Christine Power, Sijmen A. Reijneveld, Fernando Rivadeneira, Angela Simpson, Peter D. Sly, Jakob Stokholm, Kook K. Teo, Elisabeth Thiering, Nicholas J. Timpson, André G. Uitterlinden, Catharina E. M. van Beijsterveldt, Barbera D. C. van Schaik, Marc Vaudel, Elvira Verduci, Rebecca K. Vinding, Mandy Vogel, Eleftheria Zeggini, Sylvain Sebert, Mads V. Lind, Christopher D. Brown, Loreto Santa-Marina, Eva Reischl, Christine Frithioff-Bøjsøe, David Meyre, Eleanor Wheeler, Ken Ong, Ellen A. Nohr, Tanja G. M. Vrijkotte, Gerard H. Koppelman, Robert Plomin, Pål R. Njølstad, George D. Dedoussis, Philippe Froguel, Thorkild I. A. Sørensen, Bo Jacobsson, Rachel M. Freathy, Babette S. Zemel, Olli Raitakari, Martine Vrijheid, Bjarke Feenstra, Leo-Pekka Lyytikäinen, Harold Snieder, Holger Kirsten, Patrick G. Holt, Joachim Heinrich, Elisabeth Widén, Jordi Sunyer, Dorret I. Boomsma, Marjo-Riitta Järvelin, Antje Körner, George Davey Smith, Jens-Christian Holm, Mustafa Atalay, Clare Murray, Hans Bisgaard, Mark I. McCarthy, Early Growth Genetics Consortium, Vincent W. V. Jaddoe, Struan F. A. Grant, Janine F. Felix
Oct 22, 2020
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a...
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