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A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Itsunari Minami, Kohei Yamada, Tomomi G Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji
May 28, 2019
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For medical applications, clinical-grade cardiac cells...
Distance Learning
The article discusses innovative approaches to education on the example of the introduction of distance learning in Russia, the main forms of its organization, the necessary means, areas of application, advantages, and...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Force- and length-dependent catastrophe activities explain interphase microtubule organization in fission yeast.
The cytoskeleton is essential for the maintenance of cell morphology in eukaryotes. In fission yeast, for example, polarized growth sites are organized by actin, whereas microtubules (MTs) acting upstream control where growth...
Aspen Tension Wood Fibers Contain β-(1---> 4)-Galactans and Acidic Arabinogalactans Retained by Cellulose Microfibrils in Gelatinous Walls.
Tatyana Gorshkova, Natalia Mokshina, Tatyana Chernova, Nadezhda Ibragimova, Vadim Salnikov, Polina Mikshina, Theodora Tryfona, Alicja Banasiak, Peter Immerzeel, Paul Dupree, Ewa J Mellerowicz
Dec 15, 2015
Adsorption of Ions at Uncharged Insoluble Monolayers.
A method is proposed for the experimental determination of the adsorption of inorganic electrolytes at a surface covered with insoluble surfactant monolayer. This task is complicated by the fact that the change of the salt...
The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.
Makoto Honda, Itsunari Minami, Norie Tooi, Nobuhiro Morone, Hisae Nishioka, Kengo Uemura, Ayae Kinoshita, John E Heuser, Norio Nakatsuji, Kazuhiro Aiba
May 28, 2019
Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), are promising materials for...
Management Problems in Global Crowdsourcing
The study aimed to develop recommendations for the optimization of settings in which the crowdsourcing project takes place. Findings show that crowdfunding projects are hybrid and include the elements of crowdsourcing...
Published by: IGI Global Scientific Publishing
Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia.
Gonçalo C Pereira, Laura Lee, Nadiia Rawlings, Joke Ouwendijk, Joanne E Parker, Tatyana N Andrienko, Jeremy M Henley, Andrew P Halestrap
Jun 24, 2020
We previously demonstrated that hexokinase II (HK2) dissociation from mitochondria during cardiac ischemia correlates with cytochrome c (cyt-c) loss, oxidative stress and subsequent reperfusion injury. However, whether HK2...
Animals Cell Respiration Dynamins Glucose-6-Phosphate Hemodynamics Hexokinase Hydrogen-Ion Concentration Ischemic preconditioning Ligands Male Mitochondria Heart Mitochondrial Dynamics Mitochondrial Membrane Transport Proteins Mitochondrial Membranes Mitochondrial Permeability Transition Pore Myocardial Ischemia Protein Binding Rats Wistar
Olfactory sniffing signals consciousness in unresponsive patients with brain injuries.
Anat Arzi, Liron Rozenkrantz, Lior Gorodisky, Danit Rozenkrantz, Yael Holtzman, Aharon Ravia, Tristan A Bekinschtein, Tatyana Galperin, Ben-Zion Krimchansky, Gal Cohen, Anna Oksamitni, Elena Aidinoff, Yaron Sacher, Noam Sobel
May 06, 2020
After severe brain injury, it can be difficult to determine the state of consciousness of a patient, to determine whether the patient is unresponsive or perhaps minimally conscious1, and to predict whether they will recover....
Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells.
Tatyana Chernova, Stefano Grosso, Xiao-Ming Sun, Angela Rubio Tenor, Joaquin Zacarias Cabeza, Andrew Craxton, Emily L Self, Apostolos Nakas, Kelvin Cain, Marion MacFarlane, Anne E Willis
Nov 04, 2022
Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.
Parimal Kumar, Trevor R Sweeney, Maxim A Skabkin, Olga V Skabkina, Christopher UT Hellen, Tatyana V Pestova
Feb 17, 2020
Ribosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA's 5'-terminal 'cap'. The minimal 'cap0' consists of N7-methylguanosine linked to the first nucleotide via a 5'-5' triphosphate (ppp) bridge. Cap0 is...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Binding Competitive Carrier Proteins Eukaryotic Initiation Factor-4E Eukaryotic Initiation Factor-4F Intracellular Signaling Peptides and Proteins Neoplasm Proteins Peptide Chain Initiation Translational Proteins RNA Caps RNA Transfer RNA-Binding Proteins Recombinant Proteins Ribosomes
Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons.
Elizabeth Bilsland, Tatyana A Tavella, Renata Krogh, Jamie E Stokes, Annabelle Roberts, James Ajioka, David R Spring, Adriano D Andricopulo, Fabio TM Costa, Stephen G Oliver
Sep 20, 2018
BACKGROUND: Violacein is a deep violet compound that is produced by a number of bacterial species. It is synthesized from tryptophan by a pathway that involves the sequential action of 5 different enzymes (encoded by genes vioA...
Antiparasitic Deoxyviolacein Escherichia coli Plasmodium falciparum Synthetic operon Trypanosoma cruzi Violacein Animals Antimalarials Antineoplastic Agents COS Cells Chlorocebus aethiops Escherichia coli Hep G2 Cells Humans Indole Alkaloids Indoles Metabolic Engineering Operon Plasmids Plasmodium falciparum Spiro Compounds Trypanocidal Agents Trypanosoma cruzi
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John
Jun 24, 2019
The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations...
Genetics as a novel tool in mining impact assessment and biomonitoring of critically endangered western chimpanzees in the Nimba Mountains, Guinea
Kathelijne Koops, Tatyana Humle, Peter Frandsen, Maegan Fitzgerald, Lucy D'Auvergne, Hazel A Jackson, Claus Børsting, Hans R Siegismund, Aly Gaspard Soumah, Christina Hvilsom
Mar 16, 2023
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.
Michal R Gdula, Tatyana B Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Jun 17, 2019
The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of local topologically associated domains (TADs), A/B compartments and formation of two...
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Jan 28, 2022
Abstract: Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e....
APP metabolism regulates tau proteostasis in human cerebral cortex neurons.
Steven Moore, Lewis DB Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J Livesey
Jun 23, 2015
Building biosecurity for synthetic biology.
Benjamin D Trump, SE Galaitsi, Evan Appleton, Diederik A Bleijs, Marie-Valentine Florin, Jimmy D Gollihar, R Alexander Hamilton, Todd Kuiken, Filippa Lentzos, Ruth Mampuys, Myriam Merad, Tatyana Novossiolova, Kenneth Oye, Edward Perkins, Natàlia Garcia-Reyero, Catherine Rhodes, Igor Linkov
Aug 11, 2020
The fast-paced field of synthetic biology is fundamentally changing the global biosecurity framework. Current biosecurity regulations and strategies are based on previous governance paradigms for pathogen-oriented security...
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
Ferdinand von Meyenn, Mario Iurlaro, Ehsan Habibi, Ning Qing Liu, Ali Salehzadeh-Yazdi, Fátima Santos, Edoardo Petrini, Inês Milagre, Miao Yu, Zhenqing Xie, Leonie I Kroeze, Tatyana B Nesterova, Joop H Jansen, Hehuang Xie, Chuan He, Wolf Reik, Hendrik G Stunnenberg
Jun 24, 2019
Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a...
Using nonhuman culture in conservation requires careful and concerted action
Susana Carvalho, Erin G Wessling, Ekwoge E Abwe, Katarina Almeida‐Warren, Mimi Arandjelovic, Christophe Boesch, Emmanuel Danquah, Mamadou Saliou Diallo, Catherine Hobaiter, Kimberley Hockings, Tatyana Humle, Rachel Ashegbofe Ikemeh, Ammie K Kalan, Lydia Luncz, Gaku Ohashi, Alejandra Pascual‐Garrido, Alex Piel, Liran Samuni, Serge Soiret, Crickette Sanz, Kathelijne Koops
Jan 10, 2022
Abstract: Discussions of how animal culture can aid the conservation crisis are burgeoning. As scientists and conservationists working to protect endangered species, we call for reflection on how the culture concept may be...
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Aug 26, 2021
Abstract: Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e....
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, HT Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Jan 28, 2022
BACKGROUND: Despite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions...
Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice.
Michael Waisberg, Tatyana Tarasenko, Brandi K Vickers, Bethany L Scott, Lisa C Willcocks, Alvaro Molina-Cruz, Matthew A Pierce, Chiung-yu Huang, Fernando J Torres-Velez, Kenneth GC Smith, Carolina Barillas-Mury, Louis H Miller, Susan K Pierce, Silvia Bolland
Aug 07, 2019
Plasmodium falciparum has exerted tremendous selective pressure on genes that improve survival in severe malarial infections. Systemic lupus erythematosus (SLE) is an autoimmune disease that is six to eight times more prevalent...
Animals Black People Brain Cytokines DNA Primers Enzyme-Linked Immunosorbent Assay Erythrocytes Female Flow Cytometry Genetic Predisposition to Disease Humans Lupus Erythematosus Systemic Malaria Cerebral Male Mice Mice Inbred C57BL Mice Knockout Organ Size Plasmodium berghei Receptors IgG Reverse Transcriptase Polymerase Chain Reaction Spleen Survival Analysis Toll-Like Receptor 7
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D Upton, Sonja Loges, Nicholas W Morrell, Werner Seeger, Ralph T Schermuly
Sep 25, 2021
Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and...
Published by: Communications biology
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