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Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in a long-term care facility in the United Kingdom.
Hayley J Brodrick, Kathy E Raven, Teemu Kallonen, Dorota Jamrozy, Beth Blane, Nicholas M Brown, Veronique Martin, M Estée Török, Julian Parkhill, Sharon Peacock
Jun 26, 2018
Humans Escherichia coli Escherichia coli Infections beta-Lactamases Escherichia coli Proteins Long-Term Care Sequence Analysis DNA Drug Resistance Multiple Bacterial United Kingdom
Published by: Genome medicine
Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in a long-term care facility in the United Kingdom.
Hayley J Brodrick, Kathy E Raven, Teemu Kallonen, Dorota Jamrozy, Beth Blane, Nicholas M Brown, Veronique Martin, M Estée Török, Julian Parkhill, Sharon J Peacock
Jul 25, 2017
BACKGROUND: Residents of long-term care facilities (LTCF) may have high carriage rates of multidrug-resistant pathogens, but are not currently included in surveillance programmes for antimicrobial resistance or...
Diversification of Colonization Factors in a Multidrug-Resistant Escherichia coli Lineage Evolving under Negative Frequency-Dependent Selection.
Alan McNally, Teemu Kallonen, Christopher Connor, Khalil Abudahab, David M Aanensen, Carolyne Horner, Sharon J Peacock, Julian Parkhill, Nicholas J Croucher, Jukka Corander
Apr 15, 2019
Escherichia coli is a major cause of bloodstream and urinary tract infections globally. The wide dissemination of multidrug-resistant (MDR) strains of extraintestinal pathogenic E. coli (ExPEC) poses a rapidly increasing public...
High-resolution sweep metagenomics using fast probabilistic inference.
Tommi Mäklin, Teemu Kallonen, Sophia David, Christine J Boinett, Ben Pascoe, Guillaume Méric, David M Aanensen, Edward J Feil, Stephen Baker, Julian Parkhill, Samuel K Sheppard, Jukka Corander, Antti Honkela
Nov 17, 2021
Determining the composition of bacterial communities beyond the level of a genus or species is challenging because of the considerable overlap between genomes representing close relatives. Here, we present the mSWEEP pipeline...
Transcriptional networks controlling the cell cycle.
Martin Bonke, Mikko Turunen, Maria Sokolova, Anna Vähärautio, Teemu Kivioja, Minna Taipale, Mikael Björklund, Jussi Taipale
Nov 04, 2020
In this work, we map the transcriptional targets of 107 previously identified Drosophila genes whose loss caused the strongest cell-cycle phenotypes in a genome-wide RNA interference screen and mine the resulting data...
Animals CDC2 Protein Kinase Cell Cycle Cell Line Cell Size Chromatin Immunoprecipitation Cluster Analysis Drosophila Feedback Physiological Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Microarray Analysis Mitosis Oligonucleotides Phosphorylation RNA Interference Sequence Analysis RNA
Structure-based design, synthesis and evaluation <em>in vitro</em> of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
Katerina Kumpan, Amit Nathubhai, Chenlu Zhang, Pauline J. Wood, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Lari Lehtio, Michael D. Threadgill
Jul 01, 2015
The tankyrases are members of the PARP superfamily; they poly(ADP-ribosyl)ate their target proteins using NAD+ as a source of electrophilic ADP-ribosyl units. The three principal protein substrates of the tankyrases...
Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits.
John Apergis-Schoute, Panagiota Iordanidou, Cedric Faure, Sonia Jego, Cornelia Schöne, Teemu Aitta-Aho, Antoine Adamantidis, Denis Burdakov
May 11, 2015
GABA hypocretin Hypothalamus melanin-concentrating hormone optogenetics orexin Animals Calcium Channelrhodopsins Excitatory Amino Acid Antagonists Hypothalamic Area Lateral Hypothalamic Hormones In Vitro Techniques Intracellular Signaling Peptides and Proteins Luminescent Proteins Lysine Melanins Membrane Potentials Mice Nerve Net Neural Inhibition Neurons Neuropeptides Optogenetics Orexins Patch-Clamp Techniques Pituitary Hormones Signal Transduction Transduction Genetic gamma-Aminobutyric Acid
Genomic landscape of extended-spectrum β-lactamase resistance in $\textit{Escherichia coli}$ from an urban African setting
P Musicha, NA Feasey, AK Cain, T Kallonen, C Chaguza, C Peno, M Khonga, S Thompson, KJ Gray, AE Mather, RS Heyderman, DB Everett, NR Thomson, CL Msefula
Apr 25, 2017
Adolescent Adult Child Child Preschool Chloramphenicol Drug Resistance Multiple Bacterial Escherichia coli Escherichia coli Infections Female Genes Bacterial genetic variation Genomics Humans Malawi Male Microbial Sensitivity Tests Multilocus Sequence Typing Phylogeny Urban Population Young Adult beta-Lactam Resistance beta-Lactamases
Structure-based design, synthesis and evaluation <em>in vitro</em> of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
Katerina Kumpan, Amit Nathubhai, Chenlu Zhang, Pauline J. Wood, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Lari Lehtio, Michael D. Threadgill
Jul 01, 2015
The tankyrases are members of the PARP superfamily; they poly(ADP-ribosyl)ate their target proteins using NAD+ as a source of electrophilic ADP-ribosyl units. The three principal protein substrates of the tankyrases...
Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity
Amit Nathubhai, Teemu Haikarainen, Jarkko Koivunen, Sudarshan Murthy, Francoise Koumanov, Matthew Lloyd, Geoffrey Holman, Taina Pihlajaniemi, David Tosh, Lari Lehtio, Michael Threadgill
Jan 26, 2017
Compounds 13 and 14 were evaluated against eleven PARP isoforms to reveal that both 13 and 14 were more potent and isoform-selective towards inhibiting tankyrases (TNKSs) than the “standard” inhibitor 1 (XAV939)5, i.e. IC50 =...
Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases
Amit Nathubhai, Teemu Haikarainen, Penelope C Hayward, Silvia Munoz-Descalzo, Andrew S Thompson, Matthew D Lloyd, Lari Lehtio, Michael Threadgill
Aug 08, 2016
Tankyrases (TNKSs), members of the PARP (Poly(ADP-ribose)polymerases) superfamily of enzymes, have gained interest as therapeutic drug targets, especially as they are involved in the regulation of Wnt signalling. A series of...
Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases
Amit Nathubhai, Teemu Haikarainen, Penelope C Hayward, Silvia Munoz-Descalzo, Andrew S Thompson, Matthew D Lloyd, Lari Lehtio, Michael Threadgill
Aug 08, 2016
Tankyrases (TNKSs), members of the PARP (Poly(ADP-ribose)polymerases) superfamily of enzymes, have gained interest as therapeutic drug targets, especially as they are involved in the regulation of Wnt signalling. A series of...
Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity
Amit Nathubhai, Teemu Haikarainen, Jarkko Koivunen, Sudarshan Murthy, Francoise Koumanov, Matthew Lloyd, Geoffrey Holman, Taina Pihlajaniemi, David Tosh, Lari Lehtio, Michael Threadgill
Jan 26, 2017
Compounds 13 and 14 were evaluated against eleven PARP isoforms to reveal that both 13 and 14 were more potent and isoform-selective towards inhibiting tankyrases (TNKSs) than the “standard” inhibitor 1 (XAV939)5, i.e. IC50 =...
The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Jaana Lindström, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Jul 15, 2022
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors <em>in vitro</em>
Helen A. Paine, Amit Nathubhai, Esther C. Y. Woon, Peter T. Sunderland, Pauline J. Wood, Mary F. Mahon, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Mohit Narwal, Lari Lehtio, Michael D. Threadgill
Sep 01, 2015
Tankyrases-1 and -2 (TNKS-1 and TNKS-2) have three cellular roles which make them important targets in cancer. Using NAD+ as a substrate, they poly(ADP-ribosyl)ate TRF1 (regulating lengths of telomeres), NuMA...
A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes
Karolina Tuomisto, Joonatan Palmu, Tao Long, Jeramie D Watrous, Kysha Mercader, Kim A Lagerborg, Allen Andres, Marko Salmi, Sirpa Jalkanen, Ramachandran S Vasan, Michael Inouye, Aki S Havulinna, Jaakko Tuomilehto, Pekka Jousilahti, Teemu J Niiranen, Susan Cheng, Mohit Jain, Veikko Salomaa
May 09, 2022
INTRODUCTION: Peptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this...
A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes
Karolina Tuomisto, Joonatan Palmu, Tao Long, Jeramie D Watrous, Kysha Mercader, Kim A Lagerborg, Allen Andres, Marko Salmi, Sirpa Jalkanen, Ramachandran S Vasan, Michael Inouye, Aki S Havulinna, Jaakko Tuomilehto, Pekka Jousilahti, Teemu J Niiranen, Susan Cheng, Mohit Jain, Veikko Salomaa
Apr 05, 2022
INTRODUCTION: Peptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this...
Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour.
Judit García-González, Alistair J Brock, Matthew O Parker, Riva J Riley, David Joliffe, Ari Sudwarts, Muy-Teck Teh, Elisabeth M Busch-Nentwich, Derek L Stemple, Adrian R Martineau, Jaakko Kaprio, Teemu Palviainen, Valerie Kuan, Robert T Walton, Caroline H Brennan
May 18, 2020
To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F3 sibling groups, where each was derived...
acoustic startle conditioned place preference gene association neuroscience Nicotine slit3 Smoking Zebrafish Amisulpride Animals Bupropion Choice Behavior Conditioning Classical Female Genetic Loci Humans Intracellular Signaling Peptides and Proteins Male Membrane Proteins Mutation Nicotine Polymorphism Single Nucleotide Receptor Serotonin 5-HT1A tobacco smoking Zebrafish Zebrafish Proteins
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
Atiqul Haq Mazumder, Jennifer Barnett, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Jarmo Hietala, Erkki Isometsä, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Solja Niemelä, Jari Tiihonen, Tiina Paunio, Aarno Palotie, Jaana Suvisaari, Juha Veijola
May 24, 2021
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia...
Taxonomic signatures of cause-specific mortality risk in human gut microbiome.
Aaro Salosensaari, Ville Laitinen, Aki S Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D Watrous, Tao Long, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti, Teemu Niiranen
Jun 12, 2021
The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally...
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