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Results: 13
Prognostic effect of cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma
Tobias Klatte, Kate Fife, Sarah J Welsh, Manavi Sachdeva, James N Armitage, Tevita 'Aho, Antony C Riddick, Athena Matakidou, Tim Eisen, Grant D Stewart
Feb 23, 2018
PURPOSE: To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS...
Nephrectomy Pazopanib Prognosis Sunitinib survival Aged Anilides Antibodies Monoclonal Antineoplastic Agents Carcinoma Renal Cell Cohort Studies Combined Modality Therapy Cytoreduction Surgical Procedures Female Humans Indazoles Indoles Kaplan-Meier Estimate Kidney Neoplasms Liver Neoplasms Lung Neoplasms Male Middle Aged Molecular Targeted Therapy Neoplasm Metastasis Nephrectomy Nivolumab Probability Prognosis Proportional Hazards Models Pyridines Pyrimidines Pyrroles Retrospective Studies Sex Factors Sulfonamides Sunitinib Survival Rate Thrombocytosis
The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma
Tobias Klatte, Kevin M. Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony C. P. Riddick, James N. Armitage, Tevita F. ‘Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J. Pantuck, Grant D. Stewart
Oct 02, 2020
Abstract: Background: The current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed...
The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma
Tobias Klatte, Kevin M Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony CP Riddick, James N Armitage, Tevita F 'Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J Pantuck, Grant D Stewart
Oct 09, 2019
BACKGROUND: The current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed as the same...
Adjuvant Localised Papillary Prognosis Recurrence SURVEILLANCE Adult Aged Carcinoma Renal Cell Clinical Trials as Topic Cohort Studies Female Humans Incidence Kidney Neoplasms Male Middle Aged Models Statistical Neoplasm Recurrence Local Neoplasm Staging Predictive Value of Tests Prognosis Prospective Studies Research Design Risk Factors Treatment Outcome
Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors
Christopher G. Smith, Tina Moser, Florent Mouliere, Johanna Field-Rayner, Matthew Eldridge, Anja L. Riediger, Dineika Chandrananda, Katrin Heider, Jonathan C. M. Wan, Anne Y. Warren, James Morris, Irena Hudecova, Wendy N. Cooper, Thomas J. Mitchell, Davina Gale, Andrea Ruiz-Valdepenas, Tobias Klatte, Stephan Ursprung, Evis Sala, Antony C. P. Riddick, Tevita F. Aho, James N. Armitage, Samantha Perakis, Martin Pichler, Maximilian Seles, Gabriel Wcislo, Sarah J. Welsh, Athena Matakidou, Tim Eisen, Charles E. Massie, Nitzan Rosenfeld, Ellen Heitzer, Grant D. Stewart
Feb 27, 2021
Abstract: Background: Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. Methods: Here, a combination of untargeted and targeted...
Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.
Christopher G Smith, Tina Moser, Florent Mouliere, Johanna Field-Rayner, Matthew Eldridge, Anja L Riediger, Dineika Chandrananda, Katrin Heider, Jonathan CM Wan, Anne Y Warren, James Morris, Irena Hudecova, Wendy N Cooper, Thomas J Mitchell, Davina Gale, Andrea Ruiz-Valdepenas, Tobias Klatte, Stephan Ursprung, Evis Sala, Antony CP Riddick, Tevita F Aho, James N Armitage, Samantha Perakis, Martin Pichler, Maximilian Seles, Gabriel Wcislo, Sarah J Welsh, Athena Matakidou, Tim Eisen, Charles E Massie, Nitzan Rosenfeld, Ellen Heitzer, Grant D Stewart
Feb 14, 2020
BACKGROUND: Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. METHODS: Here, a combination of untargeted and targeted sequencing...
Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors
Christopher G. Smith, Tina Moser, Florent Mouliere, Johanna Field-Rayner, Matthew Eldridge, Anja L. Riediger, Dineika Chandrananda, Katrin Heider, Jonathan C. M. Wan, Anne Y. Warren, James Morris, Irena Hudecova, Wendy N. Cooper, Thomas J. Mitchell, Davina Gale, Andrea Ruiz-Valdepenas, Tobias Klatte, Stephan Ursprung, Evis Sala, Antony C. P. Riddick, Tevita F. Aho, James N. Armitage, Samantha Perakis, Martin Pichler, Maximilian Seles, Gabriel Wcislo, Sarah J. Welsh, Athena Matakidou, Tim Eisen, Charles E. Massie, Nitzan Rosenfeld, Ellen Heitzer, Grant D. Stewart
Jun 06, 2020
Abstract: Background: Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. Methods: Here, a combination of untargeted and targeted...
Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits.
John Apergis-Schoute, Panagiota Iordanidou, Cedric Faure, Sonia Jego, Cornelia Schöne, Teemu Aitta-Aho, Antoine Adamantidis, Denis Burdakov
May 11, 2015
GABA hypocretin Hypothalamus melanin-concentrating hormone optogenetics orexin Animals Calcium Channelrhodopsins Excitatory Amino Acid Antagonists Hypothalamic Area Lateral Hypothalamic Hormones In Vitro Techniques Intracellular Signaling Peptides and Proteins Luminescent Proteins Lysine Melanins Membrane Potentials Mice Nerve Net Neural Inhibition Neurons Neuropeptides Optogenetics Orexins Patch-Clamp Techniques Pituitary Hormones Signal Transduction Transduction Genetic gamma-Aminobutyric Acid
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.
Stephan Ursprung, Ramona Woitek, Mary A McLean, Andrew N Priest, Mireia Crispin-Ortuzar, Cara R Brodie, Andrew B Gill, Marcel Gehrung, Lucian Beer, Antony CP Riddick, Johanna Field-Rayner, James T Grist, Surrin S Deen, Frank Riemer, Joshua D Kaggie, Fulvio Zaccagna, Joao AG Duarte, Matthew J Locke, Amy Frary, Tevita F Aho, James N Armitage, Ruth Casey, Iosif A Mendichovszky, Sarah J Welsh, Tristan Barrett, Martin J Graves, Tim Eisen, Thomas J Mitchell, Anne Y Warren, Kevin M Brindle, Evis Sala, Grant D Stewart, Ferdia A Gallagher
Feb 20, 2022
Differentiating aggressive clear cell renal cell carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of renal tumors using carbon-13...
Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.
Christopher G Smith, Tina Moser, Florent Mouliere, Johanna Field-Rayner, Matthew Eldridge, Anja L Riediger, Dineika Chandrananda, Katrin Heider, Jonathan C M Wan, Anne Y Warren, James Morris, Irena Hudecova, Wendy N Cooper, Thomas J Mitchell, Davina Gale, Andrea Ruiz-Valdepenas, Tobias Klatte, Stephan Ursprung, Evis Sala, Antony C P Riddick, Tevita F Aho, James N Armitage, Samantha Perakis, Martin Pichler, Maximilian Seles, Gabriel Wcislo, Sarah J Welsh, Athena Matakidou, Tim Eisen, Charles E Massie, Nitzan Rosenfeld, Ellen Heitzer, Grant D Stewart
Mar 31, 2020
BACKGROUND:Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. METHODS:Here, a combination of untargeted and targeted sequencing...
Published by: Genome medicine
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.
Stephan Ursprung, Ramona Woitek, Mary McLean, Andrew N Priest, Mireia Crispin-Ortuzar, Cara R Brodie, Andrew Gill, Marcel Gehrung, Lucian Beer, Antony CP Riddick, Johanna Field-Rayner, James T Grist, Surrin S Deen, Frank Riemer, Joshua Kaggie, Fulvio Zaccagna, Joao AG Duarte, Matthew J Locke, Amy Frary, Tevita F Aho, James N Armitage, Ruth Casey, Iosif A Mendichovszky, Sarah Welsh, Tristan Barrett, Martin Graves, Tim Eisen, Thomas J Mitchell, Anne Warren, Kevin Brindle, Evis Sala, Grant Stewart, Ferdia Gallagher
Jan 28, 2022
Differentiating aggressive clear cell renal cell carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of renal tumors using carbon-13...
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
Matthew D Young, Thomas J Mitchell, Felipe A Vieira Braga, Maxine GB Tran, Benjamin J Stewart, John R Ferdinand, Grace Collord, Rachel A Botting, Dorin-Mirel Popescu, Kevin W Loudon, Roser Vento-Tormo, Emily Stephenson, Alex Cagan, Sarah J Farndon, Martin Del Castillo Velasco-Herrera, Charlotte Guzzo, Nathan Richoz, Lira Mamanova, Tevita Aho, James N Armitage, Antony CP Riddick, Imran Mushtaq, Stephen Farrell, Dyanne Rampling, James Nicholson, Andrew Filby, Johanna Burge, Steven Lisgo, Patrick H Maxwell, Susan Lindsay, Anne Y Warren, Grant D Stewart, Neil Sebire, Nicholas Coleman, Muzlifah Haniffa, Sarah A Teichmann, Menna Clatworthy, Sam Behjati
Nov 13, 2018
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal...
Spatiotemporal immune zonation of the human kidney.
Benjamin J Stewart, John R Ferdinand, Matthew D Young, Thomas J Mitchell, Kevin W Loudon, Alexandra M Riding, Nathan Richoz, Gordon L Frazer, Joy UL Staniforth, Felipe A Vieira Braga, Rachel A Botting, Dorin-Mirel Popescu, Roser Vento-Tormo, Emily Stephenson, Alex Cagan, Sarah J Farndon, Krzysztof Polanski, Mirjana Efremova, Kile Green, Martin Del Castillo Velasco-Herrera, Charlotte Guzzo, Grace Collord, Lira Mamanova, Tevita Aho, James N Armitage, Antony CP Riddick, Imran Mushtaq, Stephen Farrell, Dyanne Rampling, James Nicholson, Andrew Filby, Johanna Burge, Steven Lisgo, Susan Lindsay, Marc Bajenoff, Anne Y Warren, Grant D Stewart, Neil Sebire, Nicholas Coleman, Muzlifah Haniffa, Sarah A Teichmann, Sam Behjati, Menna R Clatworthy
Oct 07, 2019