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Results: 82
Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro
Mariel Therese Bartley
Jan 01, 0001
Adenosine deaminases acting on RNA (ADARs) convert adenosine-to-inosine in double stranded RNA. Selectivity of editing sites depends on the sequence of the RNA as well as the secondary structure. Identification of sites of ADAR...
Published by: Rockefeller University
Delaying and reversing frailty
BACKGROUND: Recommendations for routine frailty screening in general practice are increasing as frailty prevalence grows. In England, frailty identification became a contractual requirement in 2017. However, there is little...
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Preliminary paleoecological insights from the Pliocene avifauna of Kanapoi, Kenya
Daniel J. Field
Mar 31, 2020

Fossil bird remains from the Pliocene hominin-bearing locality of Kanapoi comprise >100 elements representing at least 10 avian families, including previously undescribed elements referred to the ‘giant’ Pliocene marabou...

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Preliminary paleoecological insights from the Pliocene avifauna of Kanapoi, Kenya
Daniel J. Field
Mar 31, 2020

Fossil bird remains from the Pliocene hominin-bearing locality of Kanapoi comprise >100 elements representing at least 10 avian families, including previously undescribed elements referred to the ‘giant’ Pliocene marabou...

Published by:
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
Abstract: DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that...
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Microfluidic approaches for probing amyloid assembly and behaviour.
The self-assembly of proteins into supramolecular structures and machinery underpins biological activity in living systems. Misassembled, misfolded and aggregated protein structures can, by contrast, have deleterious activity...
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Rapid two-dimensional characterisation of proteins in solution.
Microfluidic platforms provide an excellent basis for working with heterogeneous samples and separating biomolecular components at high throughput, with high recovery rates and by using only very small sample volumes. To date...
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Representing defeat
Hanna Diamond
Dec 01, 2008
This exploratory article analyses a number of photographs concerning events of the first two years of the Second World War in France. It focuses on two key groups of pictures: the first presents the official and strategic...
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Representing defeat
Hanna Diamond
Dec 01, 2008
This exploratory article analyses a number of photographs concerning events of the first two years of the Second World War in France. It focuses on two key groups of pictures: the first presents the official and strategic...
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Dancing With Storks
H Ishihara, U Pascual, I Hodge
Aug 09, 2017
The institutional change induced by payments for ecosystem services (PES) schemes is a ‘messy’ process. The uptake and outcomes of PES schemes cannot be fully explained from a rational choice perspective. The notion of...
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Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus.
DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein...
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Accelerated vascular aging
Background and aims: Risk of stroke and dementia is markedly higher in people of South Asian and African Caribbean descent than white Europeans in the UK. This is unexplained by cardiovascular risk factors (CVRF). We...
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Ethnicity and prediction of cardiovascular disease
OBJECTIVE: To evaluate QRISK2 and Framingham cardiovascular disease (CVD) risk scores in a tri-ethnic U.K. population. DESIGN: Cohort study. SETTING: West London. PARTICIPANTS: Randomly selected from primary care lists....
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