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Systemic approaches to incident analysis in aviation
The rapid development and increasing complexity of modern socio-technical systems suggest an urgent need for systemic safety analysis approaches because traditional linear models cannot cope with this complexity. In the...
Quantitative interpretation explains machine learning models for chemical reaction prediction and uncovers bias
Abstract: Organic synthesis remains a major challenge in drug discovery. Although a plethora of machine learning models have been proposed as solutions in the literature, they suffer from being opaque black-boxes. It is neither...
Systemic approaches to incident analysis in aviation
The rapid development and increasing complexity of modern socio-technical systems suggest an urgent need for systemic safety analysis approaches because traditional linear models cannot cope with this complexity. In the...
Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster.
Protein ubiquitylation is a dynamic process that affects the function and stability of proteins and controls essential cellular processes ranging from cell proliferation to cell death. This process is regulated through the...
Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster.
In most Eukaryotes, ubiquitin either exists as free monoubiquitin or as a molecule that is covalently linked to other proteins. These two forms cycle between each other and due to the concerted antagonistic activity of...
Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells
Tibor Kalmar, Chea Lim, Penelope Hayward, Silvia Muñoz-Descalzo, Jennifer Nichols, Jordi Garcia-Ojalvo, Alfonso Martinez Arias
Jul 01, 2009
There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using fluorescent reporters for the expression...
Quantitative interpretation explains machine learning models for chemical reaction prediction and uncovers bias.
Organic synthesis remains a major challenge in drug discovery. Although a plethora of machine learning models have been proposed as solutions in the literature, they suffer from being opaque black-boxes. It is neither clear if...
The second law of black hole mechanics in effective field theory
Abstract
We investigate the second law of black hole mechanics in gravitational theories with higher derivative terms in the action. Wall has described a...
Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells
Tibor Kalmar, Chea Lim, Penelope Hayward, Silvia Muñoz-Descalzo, Jennifer Nichols, Jordi Garcia-Ojalvo, Alfonso Martinez Arias
Jul 01, 2009
There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using fluorescent reporters for the expression...
Towards robust design of thin film transition edge sensors for use in the next-generation superconducting radio frequency cavities
Alexander Lunt, Zsolt Kovács, Hernán Furci, Torsten Koettig, Floriane Léaux, Giovanna Vandoni
May 15, 2017
In order to increase the accelerating gradient, the next-generation of Superconducting Radio Frequency (SRF) cavities will be operated with superfluid helium cooling. This upgrade requires the development of a...
Challenges of the Fourth Industrial Revolution in HRM
As a result of the changes caused by Industry 4.0 and Industry 5.0, unknown or less prominent challenges will be the focus of the operation of organizations and will essentially transform current human resource management (HRM)...
Published by: IGI Global Scientific Publishing
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
Towards robust design of thin film transition edge sensors for use in the next-generation superconducting radio frequency cavities
Alexander Lunt, Zsolt Kovács, Hernán Furci, Torsten Koettig, Floriane Léaux, Giovanna Vandoni
May 15, 2017
In order to increase the accelerating gradient, the next-generation of Superconducting Radio Frequency (SRF) cavities will be operated with superfluid helium cooling. This upgrade requires the development of a...
ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 06, 2023
Study of Ti contacts to corundum α -Ga 2 O 3
Abstract: We present a study of the electrical, structural and chemical properties of Ti contacts on atomic layer deposited α-Ga2O3 film. Ti forms an ohmic contact with α-Ga2O3. The contact performance is highly dependent on the...
ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations.
Bálint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A Glynn, Rita Bori, Erika Csörgő, Orsolya Oláh-Németh, Tamás Pancsa, Anita Sejben, István Sejben, András Vörös, Tamás Zombori, Tibor Nyári, Grace Callagy, Gábor Cserni
Mar 28, 2023
Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate...
reproducibility Breast Cancer TILs triple-negative Tumour-infiltrating lymphocytes sTILs ONEST international immuno-oncology biomarker working group European Working Group for Breast Screening Pathology observers needed to evaluate subjective tests
Published by: Cancers
Study of Ti contacts to corundum α -Ga 2 O 3
Abstract: We present a study of the electrical, structural and chemical properties of Ti contacts on atomic layer deposited α-Ga2O3 film. Ti forms an ohmic contact with α-Ga2O3. The contact performance is highly dependent on the...
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