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Investigating Cytotoxicity and Defense functions of bacteriophage Larva genes in host Mycobacterium smegmatis
It is estimated that approximately 75% of gene functions within any given phage cluster remain unknown. Two phage traits that can be measured phenotypically were investigated: cytotoxicity, which causes host cell lysis, and...
Published by: Winthrop University
Localized smoothing and concentration for the Navier-Stokes equations in the half space
We establish a local-in-space short-time smoothing effect for the Navier-Stokes equations in the half space. The whole space analogue, due to Jia and Šverák [21], is a central tool in two of the authors' recent work on...
Critical Thinking Class Dissects JFK Assassination During This 50th Anniversary
Winthrop University
Jan 01, 0001
The English instructor took a general education critical thinking class and added a twist: the class spent the entire semester focused on what happened during the assassination of John F. Kennedy, our 35th president. The 50th...
Published by: Winthrop University
Localized smoothing and concentration for the Navier-Stokes equations in the half space
We establish a local-in-space short-time smoothing effect for the Navier-Stokes equations in the half space. The whole space analogue, due to Jia and Šverák [21], is a central tool in two of the authors' recent work on...
Do T.V. and Music Affect Your Workout? A Winthrop Graduate Assistant Says...
Winthrop University
Jan 01, 0001
Nicole Swank is a graduate assistant from Dallas, Texas. She is pursuing a master's in sport and fitness administration. According to several new studies, the type of television program you watch during a workout can affect...
Published by: Winthrop University
A molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer
David T.j. Morris, Steven M. Wales, David P. Tilly, Elliot H.e. Farrar, Matthew N. Grayson, John W. Ward, Jonathan Clayden
Sep 09, 2021
Communication of information through the global switching of conformation in synthetic molecules has hitherto entailed the inversion of chirality. Here, we report a class of oligomer through which information may be communicated...
A molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer
David T.j. Morris, Steven M. Wales, David P. Tilly, Elliot H.e. Farrar, Matthew N. Grayson, John W. Ward, Jonathan Clayden
Sep 09, 2021
Communication of information through the global switching of conformation in synthetic molecules has hitherto entailed the inversion of chirality. Here, we report a class of oligomer through which information may be communicated...
Highlights of the thirteenth annual scientific meeting of the Society of Cardiovascular Computed Tomography.
Jonathan R Weir-McCall, Nidhi Madan, Todd C Villines, Leslee J Shaw, Suhny Abbara, Maros Ferencik, Koen Nieman, Ron Blankstein, Brian B Ghoshhajra, Andrew D Choi, Edward Nicol
Dec 20, 2018
The 13th Annual Scientific Meeting of the SCCT, held from July 13 to July 15 in Dallas, TX, was attended by 690 attendees from 39 countries, 55 sessions with 140 speakers, and 18 exhibitors with the abstracts of all scientific...
Dr. Stephanie Milling Elected to Americans for the Arts' Arts Education Council
Winthrop University
Jan 01, 0001
Milling brings more than 12 years of arts education experience and dedication to the Council, having maintained a commitment to arts advocacy in South Carolina and the nation and recently received the South Carolina Dance...
Published by: Winthrop University
Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a primary care setting.
Dallas P Seitz, Calvin Ch Chan, Hailey T Newton, Sudeep S Gill, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Bruce A Fage
Oct 03, 2018
BACKGROUND: Alzheimer's disease and other forms of dementia are becoming increasingly common with the aging of most populations. The majority of individuals with dementia will first present for care and assessment in primary...
Somatic mutation rates scale with lifespan across mammals.
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim HH Coorens, Mathijs A Sanders, Andrew RJ Lawson, Luke MR Harvey, Shriram Bhosle, David Jones, Raul E Alcantara, Timothy M Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan St John Smith, Moritz Gerstung, Peter J Campbell, Elizabeth P Murchison, Michael R Stratton, Iñigo Martincorena
May 15, 2022
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1-7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the...
Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a community setting.
Bruce A Fage, Calvin Ch Chan, Sudeep S Gill, Anna H Noel-Storr, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Dallas P Seitz
Oct 03, 2018
BACKGROUND: Alzheimer's disease and related forms of dementia are becoming increasingly prevalent with the aging of many populations. The diagnosis of Alzheimer's disease relies on tests to evaluate cognition and discriminate...
Somatic mutation rates scale with lifespan across mammals
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim HH Coorens, Mathijs A Sanders, Andrew RJ Lawson, Luke MR Harvey, Shriram Bhosle, David Jones, Raul E Alcantara, Timothy M Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan St John Smith, Moritz Gerstung, Peter J Campbell, Elizabeth P Murchison, Michael R Stratton, Iñigo Martincorena
Apr 20, 2022
Abstract: The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1–7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses...
Ursinus College Alumni Journal, March 1964
Richard T. Schellhase, Lucille Hunt Bone, Charles Hudnut, Kay Kerper Schellhase, Roger P. Staiger, Raymond V. Gurzynski, Blanche B. Schultz, Donald L. Helfferich, Geoffrey Dolman, H. Lloyd Jones, Thomas J. Beddow, Chadwick F. Alger, James T. Barbash, Frederick S. Carney, John Bradley
Jan 01, 0001
Standing room only New student facilities building Campaign receipts reach $285,765 at mid-March Matching gifts Mid-year report of 1964 Loyalty Fund campaign Income while you live . . . benefaction when you die Cutting...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages admissions Wismer Hall Basketball wrestling Carleton S. Coon Dwight R. Kirkpatrick John F. Kennedy Paul I. Guest C. Richard Snyder William D. Reimert Wainright E. H. Diehl Marguerite Goldthwaite Godshall Franklin E. Morris J. William Ditter Jr. Robert Poole III Andy Bain Dick Edwards Higher Education Social History United States History
Published by: Ursinus College
Somatic mutation rates scale with lifespan across mammals.
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim HH Coorens, Mathijs A Sanders, Andrew RJ Lawson, Luke MR Harvey, Shriram Bhosle, David Jones, Raul E Alcantara, Timothy M Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan Smith, Moritz Gerstung, Peter J Campbell, Elizabeth Murchison, Michael R Stratton, Iñigo Martincorena
Apr 21, 2022
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1-7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the...
Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds.
Tuong L Nguyen, Ye K Aung, Shuai Li, Nhut Ho Trinh, Christopher F Evans, Laura Baglietto, Kavitha Krishnan, Gillian S Dite, Jennifer Stone, Dallas R English, Yun-Mi Song, Joohon Sung, Mark A Jenkins, Melissa C Southey, Graham G Giles, John L Hopper
Feb 18, 2019
BACKGROUND: Case-control studies show that mammographic density is a better risk factor when defined at higher than conventional pixel-brightness thresholds. We asked if this applied to interval and/or screen-detected cancers....
Australian women Breast Cancer Interval cancer Mammographic density Mammography Masking effect Nested case–control cohort study Screen-detected Aged Breast Breast Density Breast Neoplasms Case-Control Studies Early Detection of Cancer Female Humans Image Processing Computer-Assisted Mammography Middle Aged Prognosis Prospective Studies Risk Assessment Risk Factors Software
Prospective Evaluation over 15 Years of Six Breast Cancer Risk Models
Sherly X. Li, Roger L. Milne, Tú Nguyen-Dumont, Dallas R. English, Graham G. Giles, Melissa C. Southey, Antonis C. Antoniou, Andrew Lee, Ingrid Winship, John L. Hopper, Mary Beth Terry, Robert J. MacInnis
Oct 18, 2021
Prospective validation of risk models is needed to assess their clinical utility, particularly over the longer term. We evaluated the performance of six commonly used breast cancer risk models (IBIS, BOADICEA, BRCAPRO...
Understanding the Economic Impact of the Carolina Panthers Training Facility on Rock Hill
Jeremiah Hart
Jan 01, 0001
In June 2019, the construction of both a new training facility and headquarters for Charlotte's largest sports franchise was announced. Rock Hill, South Carolina, was selected as the new site for the facilities. This decision...
Published by: Winthrop University
Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models.
Sherly X Li, Roger L Milne, Tu Nguyen-Dumont, Xiaochuan Wang, Dallas R English, Graham G Giles, Melissa C Southey, Antonis C Antoniou, Andrew Lee, Shuai Li, Ingrid Winship, John L Hopper, Mary Beth Terry, Robert J Macinnis
Feb 24, 2021
BACKGROUND: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer risk models are used to provide advice on screening intervals...
Adult Aged Algorithms Breast Neoplasms Confidence Intervals Family Health Female Genetic Predisposition to Disease genetic variation Humans Life Style Medical History Taking Middle Aged Models Statistical Polymorphism Single Nucleotide Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors Time Factors
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
Na Zhu, Emilia M Swietlik, Carrie L Welch, Michael W Pauciulo, Jacob J Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A Lutz, Jennifer M Martin, Carmen M Treacy, Erika B Rosenzweig, Usha Krishnan, Anna W Coleman, Claudia Gonzaga-Jauregui, Allan Lawrie, Richard C Trembath, Martin R Wilkins, Nicholas W Morrell, Yufeng Shen, Stefan Gräf, William C Nichols, Wendy K Chung
Jun 11, 2021
Background
Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and heart...
Genetics genome sequencing pulmonary arterial hypertension Exome Sequencing Case-control association testing De novo variant analysis
Published by: Genome medicine
WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Meghna Kannan, Efil Bayam, Christel Wagner, Bruno Rinaldi, Perrine F Kretz, Peggy Tilly, Marna Roos, Lara McGillewie, Séverine Bär, Shilpi Minocha, Claire Chevalier, Chrystelle Po, Sanger Mouse Genetics Project, Jamel Chelly, Jean-Louis Mandel, Renato Borgatti, Amélie Piton, Craig Kinnear, Ben Loos, David J Adams, Yann Hérault, Stephan C Collins, Sylvie Friant, Juliette D Godin, Binnaz Yalcin
Feb 24, 2021
The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes assessed, we found 7 displaying a major impact in neuronal...
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