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Results: 17
Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering.
Andreas Santamaria, Krishna C Batchu, Olga Matsarskaia, Sylvain F Prévost, Daniela Russo, Francesca Natali, Tilo Seydel, Ingo Hoffmann, Valérie Laux, Michael Haertlein, Tamim A Darwish, Robert A Russell, Giacomo Corucci, Giovanna Fragneto, Armando Maestro, Nathan R Zaccai
Mar 18, 2022
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Sep 16, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Marthe HR Ludtmann, Plamena R Angelova, Mathew H Horrocks, Minee L Choi, Margarida Rodrigues, Artyom Y Baev, Alexey V Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T Ranasinghe, Daniel R Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Oct 10, 2018
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that...
Animals Coculture Techniques Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Lipid Peroxidation Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Mitochondrial Proton-Translocating ATPases Neurons Oxidation-Reduction Parkinson Disease Patch-Clamp Techniques Permeability Proteomics Rats Rats Sprague-Dawley Reactive Oxygen Species ALPHA-SYNUCLEIN
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Feb 09, 2021
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Oct 12, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Alpha synuclein aggregation drives ferroptosis
Plamena R Angelova, Minee L Choi, Alexey V Berezhnov, Mathew H Horrocks, Craig D Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S Dolt, Tilo Kunath, Michael J Devine, Paul Gissen, Mikhail S Shchepinov, Sergiy Sylantyev, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Apr 27, 2021
Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Oct 02, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Minee L Choi, Alexandre Chappard, Bhanu P Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I Fedotova, Alexey V Berezhnov, Suman De, Christopher J Peddie, Dilan Athauda, Gurvir S Virdi, Weijia Zhang, James R Evans, Anna I Wernick, Zeinab Shadman Zanjani, Plamena R Angelova, Noemi Esteras, Andrey Y Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y Abramov, Mathew H Horrocks, Sonia Gandhi
Oct 24, 2022
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the...
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Minee L Choi, Alexandre Chappard, Bhanu P Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I Fedotova, Alexey V Berezhnov, Suman De, Christopher J Peddie, Dilan Athauda, Gurvir S Virdi, Weijia Zhang, James R Evans, Anna I Wernick, Zeinab Shadman Zanjani, Plamena R Angelova, Noemi Esteras, Andrey Y Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y Abramov, Mathew H Horrocks, Sonia Gandhi
Sep 07, 2022
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the...
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I. Fedotova, Alexey V. Berezhnov, Suman De, Christopher J. Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna I. Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Y. Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Oct 24, 2022
Abstract: Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked...
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
Sean R McWhinney, Katharina Brosch, Vince D Calhoun, Benedicto Crespo-Facorro, Nicolas A Crossley, Udo Dannlowski, Erin Dickie, Lorielle M F Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T J Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadić, Nils Opel, Julia-Katharina Pfarr, Amanda L Rodrigue, Kelly Rootes-Murdy, Alex J Ross, Kang Sim, Antonín Škoch, Filip Spaniel, Frederike Stein, Patrik Švancer, Diana Tordesillas-Gutiérrez, Juan Undurraga, Javier Váquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W Weickert, Cynthia Shannon Weickert, Paul M Thompson, Theo G M van Erp, Jessica A Turner, Tomas Hajek
Sep 30, 2022
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained...
/dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/2800/2804 name=Cellular and Molecular Neuroscience /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Minee L Choi, Alexandre Chappard, Bhanu P Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I Fedotova, Alexey V Berezhnov, Suman De, Christopher J Peddie, Dilan Athauda, Gurvir S Virdi, Weijia Zhang, James R Evans, Anna I Wernick, Zeinab Shadman Zanjani, Plamena R Angelova, Noemi Esteras, Andrey Y Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y Abramov, Mathew H Horrocks, Sonia Gandhi
Sep 30, 2022
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the...
Published by: Nature neuroscience
Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals
Sean R McWhinney, Katharina Brosch, Vince D Calhoun, Benedicto Crespo-Facorro, Nicolas A Crossley, Udo Dannlowski, Erin Dickie, Lorielle M F Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T J Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadić, Nils Opel, Julia-Katharina Pfarr, Amanda L Rodrigue, Kelly Rootes-Murdy, Alex J Ross, Kang Sim, Antonín Škoch, Filip Spaniel, Frederike Stein, Patrik Švancer, Diana Tordesillas-Gutiérrez, Juan Undurraga, Javier Váquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W Weickert, Cynthia Shannon Weickert, Paul M Thompson, Theo G M van Erp, Jessica A Turner, Tomas Hajek
Sep 30, 2022
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained...
/dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/2800/2804 name=Cellular and Molecular Neuroscience /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
Matthias Kirschner, Benazir Hodzic-Santor, Mathilde Antoniades, Igor Nenadic, Tilo Kircher, Axel Krug, Tina Meller, Dominik Grotegerd, Alex Fornito, Aurina Arnatkeviciute, Mark A Bellgrove, Jeggan Tiego, Udo Dannlowski, Katharina Koch, Carina Hülsmann, Harald Kugel, Verena Enneking, Melissa Klug, Elisabeth J Leehr, Joscha Böhnlein, Marius Gruber, David Mehler, Pamela DeRosse, Ashley Moyett, Bernhard T Baune, Melissa Green, Yann Quidé, Christos Pantelis, Raymond Chan, Yi Wang, Ulrich Ettinger, Martin Debbané, Melodie Derome, Christian Gaser, Bianca Besteher, Kelly Diederen, Tom J Spencer, Paul Fletcher, Wulf Rössler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Haeme RP Park, Kristina Wiebels, Imke Lemmers-Jansen, James Gilleen, Paul Allen, Petya Kozhuharova, Jan-Bernard Marsman, Irina Lebedeva, Alexander Tomyshev, Anna Mukhorina, Stefan Kaiser, Anne-Kathrin Fett, Iris Sommer, Sanne Schuite-Koops, Casey Paquola, Sara Larivière, Boris Bernhardt, Alain Dagher, Phillip Grant, Theo GM van Erp, Jessica A Turner, Paul M Thompson, André Aleman, Gemma Modinos
Apr 29, 2022
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be...
Structural brain alterations associated with suicidal thoughts and behaviors in young people
Laura S. van Velzen, Maria R. Dauvermann, Lejla Colic, Luca M. Villa, Hannah S. Savage, Yara J. Toenders, Alyssa H. Zhu, Joanna K. Bright, Adrián I. Campos, Lauren E. Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Başgöze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle, Colm G. Connolly, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Katharina Dohm, Janice M. Fullerton, Ali Saffet Gonul, Ian H. Gotlib, Dominik Grotegerd, Tim Hahn, Ben J. Harrison, Mengxin He, Ian B. Hickie, Tiffany C. Ho, Frank Iorfino, Andreas Jansen, Fabrice Jollant, Tilo Kircher, Bonnie Klimes-Dougan, Melissa Klug, Elisabeth J. Leehr, Elizabeth T. C. Lippard, Katie A. McLaughlin, Susanne Meinert, Adam Bryant Miller, Philip B. Mitchell, Benson Mwangi, Igor Nenadić, Amar Ojha, Bronwyn J. Overs, Julia-Katharina Pfarr, Fabrizio Piras, Kai G. Ringwald, Gloria Roberts, Georg Romer, Marsal Sanches, Margaret A. Sheridan, Jair C. Soares, Gianfranco Spalletta, Frederike Stein, Giana I. Teresi, Diana Tordesillas-Gutiérrez, Aslihan Uyar-Demir, Nic J. A. van der Wee, Steven J. van der Werff, Robert R. J. M. Vermeiren, Alexandra Winter, Mon-Ju Wu, Tony T. Yang, Paul M. Thompson, Miguel E. Rentería, Neda Jahanshad, Hilary P. Blumberg, Anne-Laura van Harmelen, Lianne Schmaal
Apr 07, 2023
Structural brain alterations associated with suicidal thoughts and behaviors in young people
Laura S van Velzen, Maria R Dauvermann, Lejla Colic, Luca M Villa, Hannah S Savage, Yara J Toenders, Alyssa H Zhu, Joanna K Bright, Adrián I Campos, Lauren E Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Başgöze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle, Colm G Connolly, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Katharina Dohm, Janice M Fullerton, Ali Saffet Gonul, Ian H Gotlib, Dominik Grotegerd, Tim Hahn, Ben J Harrison, Mengxin He, Ian B Hickie, Tiffany C Ho, Frank Iorfino, Andreas Jansen, Fabrice Jollant, Tilo Kircher, Bonnie Klimes-Dougan, Melissa Klug, Elisabeth J Leehr, Elizabeth TC Lippard, Katie A McLaughlin, Susanne Meinert, Adam Bryant Miller, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Amar Ojha, Bronwyn J Overs, Julia-Katharina Pfarr, Fabrizio Piras, Kai G Ringwald, Gloria Roberts, Georg Romer, Marsal Sanches, Margaret A Sheridan, Jair C Soares, Gianfranco Spalletta, Frederike Stein, Giana I Teresi, Diana Tordesillas-Gutiérrez, Aslihan Uyar-Demir, Nic JA van der Wee, Steven J van der Werff, Robert RJM Vermeiren, Alexandra Winter, Mon-Ju Wu, Tony T Yang, Paul M Thompson, Miguel E Rentería, Neda Jahanshad, Hilary P Blumberg, Anne-Laura van Harmelen, ENIGMA Suicidal Thoughts and Behaviours Consortium, Lianne Schmaal
Dec 09, 2022
10Kin1day
Martijn P van den Heuvel, Lianne H Scholtens, Hannelore K van der Burgh, Federica Agosta, Clara Alloza, Celso Arango, Bonnie Auyeung, Simon Baron-Cohen, Silvia Basaia, Manon JNL Benders, Frauke Beyer, Linda Booij, Kees PJ Braun, Geraldo Busatto Filho, Wiepke Cahn, Dara M Cannon, Tiffany M Chaim-Avancini, Sandra SM Chan, Eric YH Chen, Benedicto Crespo-Facorro, Eveline A Crone, Udo Dannlowski, Sonja MC de Zwarte, Bruno Dietsche, Gary Donohoe, Stefan Du Plessis, Sarah Durston, Covadonga M Díaz-Caneja, Ana M Díaz-Zuluaga, Robin Emsley, Massimo Filippi, Thomas Frodl, Martin Gorges, Beata Graff, Dominik Grotegerd, Dariusz Gąsecki, Julie M Hall, Laurena Holleran, Rosemary Holt, Helene J Hopman, Andreas Jansen, Joost Janssen, Krzysztof Jodzio, Lutz Jäncke, Vasiliy G Kaleda, Jan Kassubek, Shahrzad Kharabian Masouleh, Tilo Kircher, Martijn GJC Koevoets, Vladimir S Kostic, Axel Krug, Stephen M Lawrie, Irina S Lebedeva, Edwin HM Lee, Tristram A Lett, Simon JG Lewis, Franziskus Liem, Michael V Lombardo, Carlos Lopez-Jaramillo, Daniel S Margulies, Sebastian Markett, Paulo Marques, Ignacio Martínez-Zalacaín, Colm McDonald, Andrew M McIntosh, Genevieve McPhilemy, Susanne L Meinert, José M Menchón, Christian Montag, Pedro S Moreira, Pedro Morgado, David O Mothersill, Susan Mérillat, Hans-Peter Müller, Leila Nabulsi, Pablo Najt, Krzysztof Narkiewicz, Patrycja Naumczyk, Bob Oranje, Victor Ortiz-Garcia de la Foz, Jiska S Peper, Julian A Pineda, Paul E Rasser, Ronny Redlich, Jonathan Repple, Martin Reuter, Pedro GP Rosa, Amber NV Ruigrok, Agnieszka Sabisz, Ulrich Schall, Soraya Seedat, Mauricio H Serpa, Stavros Skouras, Carles Soriano-Mas, Nuno Sousa, Edyta Szurowska, Alexander S Tomyshev, Diana Tordesillas-Gutierrez, Sofie L Valk, Leonard H Van den Berg, Theo GM van Erp, Neeltje EM van Haren, Judith MC van Leeuwen, Arno Villringer, Christiaan H Vinkers, Christian Vollmar, Lea Waller, Henrik Walter, Heather C Whalley, Marta Witkowska, A Veronica Witte, Marcus V Zanetti, Rui Zhang, Siemon C de Lange
Jun 12, 2019
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report...