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Results: 79004
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
"Photonic lantern" spectral filters in multi-core fibre
Fibre Bragg gratings are written across all 120 single-mode cores of a multi-core optical fibre. The fibre is interfaced to multimode ports by tapering it within a depressed-index glass jacket. The result is a compact multimode...
"Photonic lantern" spectral filters in multi-core fibre
Fibre Bragg gratings are written across all 120 single-mode cores of a multi-core optical fibre. The fibre is interfaced to multimode ports by tapering it within a depressed-index glass jacket. The result is a compact multimode...
Ultrafast laser inscription of an integrated photonic lantern
We used ultrafast laser inscription to fabricate three-dimensional integrated optical transitions that efficiently couple light from a multimode waveguide to a two-dimensional array of single mode waveguides and back. Although...
Stack, seal, evacuate, draw
The two-stage stack and draw technique is an established method for fabricating microstructured fibers, including hollow-core fibers. A stack of glass elements of around a meter in length and centimeters in outer diameter forms...
Stack, seal, evacuate, draw
The two-stage stack and draw technique is an established method for fabricating microstructured fibers, including hollow-core fibers. A stack of glass elements of around a meter in length and centimeters in outer diameter forms...
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Ultrafast laser inscription of an integrated photonic lantern
We used ultrafast laser inscription to fabricate three-dimensional integrated optical transitions that efficiently couple light from a multimode waveguide to a two-dimensional array of single mode waveguides and back. Although...
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
Characterizing the variation of propagation constants in multicore fiber
Peter J. Mosley, Itandehui Gris-Sánchez, James M. Stone, Robert J A Francis-Jones, Douglas J. Ashton, Tim A. Birks
Oct 20, 2014
We demonstrate a numerical technique that can evaluate the core-to-core variations in propagation constant in multicore fiber. Using a Markov Chain Monte Carlo process, we replicate the interference patterns of light that has...
Observation of rapid adiabatic passage in optical four-wave mixing
Xiaoyue Ding, Dylan Heberle, Kerrianne Harrington, Noah Flemens, Wei Zung Chang, Tim Birks, Jeffrey Moses
Apr 17, 2020
We observe clear evidence of adiabatic passage between photon populations via a four-wave mixing process, implemented through a dispersion sweep arranged by a core diameter taper of an optical fiber. Photonic rapid adiabatic...
A complex multi-notch astronomical filter to suppress the bright infrared sky
J Bland-Hawthorn, S C Ellis, S G Leon-Saval, R Haynes, M M Roth, H-G Löhmannsröben, A J Horton, J-G Cuby, Tim A Birks, J S Lawrence, P Gillingham, S D Ryder, C Trinh
Dec 06, 2011
A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is...
Observation of rapid adiabatic passage in optical four-wave mixing
Xiaoyue Ding, Dylan Heberle, Kerrianne Harrington, Noah Flemens, Wei Zung Chang, Tim Birks, Jeffrey Moses
Apr 17, 2020
We observe clear evidence of adiabatic passage between photon populations via a four-wave mixing process, implemented through a dispersion sweep arranged by a core diameter taper of an optical fiber. Photonic rapid adiabatic...
Computational optical imaging with a photonic lantern
Tim Birks, Debaditya Choudhury, Duncan McNicholl, Audrey Repetti, Itandehui Gris Sanchez, Shuhui Li, David Phillips, Graeme Whyte, Yves Wiaux, Robert Thomson
Oct 15, 2020
The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to...
Characterizing the variation of propagation constants in multicore fiber
Peter J. Mosley, Itandehui Gris-Sánchez, James M. Stone, Robert J A Francis-Jones, Douglas J. Ashton, Tim A. Birks
Oct 20, 2014
We demonstrate a numerical technique that can evaluate the core-to-core variations in propagation constant in multicore fiber. Using a Markov Chain Monte Carlo process, we replicate the interference patterns of light that has...
Optofluidic microchannels in aerogel
We report optofluidic waveguides made by filling microchannels in aerogel with water. The aerogel cladding is a nanoporous material with an extremely low refractive index of similar to 1.05, giving a large index step from the...
A complex multi-notch astronomical filter to suppress the bright infrared sky
J Bland-Hawthorn, S C Ellis, S G Leon-Saval, R Haynes, M M Roth, H-G Löhmannsröben, A J Horton, J-G Cuby, Tim A Birks, J S Lawrence, P Gillingham, S D Ryder, C Trinh
Dec 06, 2011
A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is...
Optofluidic microchannels in aerogel
We report optofluidic waveguides made by filling microchannels in aerogel with water. The aerogel cladding is a nanoporous material with an extremely low refractive index of similar to 1.05, giving a large index step from the...
Computational optical imaging with a photonic lantern
Tim Birks, Debaditya Choudhury, Duncan McNicholl, Audrey Repetti, Itandehui Gris Sanchez, Shuhui Li, David Phillips, Graeme Whyte, Yves Wiaux, Robert Thomson
Oct 15, 2020
The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to...
Guidance in Kagome-like photonic crystal fibres I
Propagation of light in a square-lattice hollow-core photonic crystal fibre is analysed as a model of guidance in a class of photonic crystal fibres that exhibit broad-band guidance without photonic bandgaps. A scalar governing...
Guidance in Kagome-like photonic crystal fibres I
Propagation of light in a square-lattice hollow-core photonic crystal fibre is analysed as a model of guidance in a class of photonic crystal fibres that exhibit broad-band guidance without photonic bandgaps. A scalar governing...
Nonlinear optics in the LP<sub>02</sub> higher-order mode of a fiber
The distinct disperion properties of higher-order modes in optical fibers permit the nonlinear generation of radiation deeper into the ultraviolet than is possible with the fundamental mode. This is exploited using adiabatic...
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