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Results: 1461
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Medical treatment of renal cancer
Renal cell carcinoma (RCC) makes up 2-3% of adult cancers. The introduction of tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin inhibitors in the mid-2000s radically changed the management of RCC. These...
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma.
Lucy Gossage, Douglas EV Pires, Álvaro Olivera-Nappa, Juan Asenjo, Mark Bycroft, Tom L Blundell, Tim Eisen
Jul 10, 2014
Treatment patterns and health outcomes in metastatic renal cell carcinoma patients treated with targeted systemic therapies in the UK
Robert Hawkins, Kate Fife, Michael Hurst, Meng Wang, Niroshini Naicker, Sarah Nolasco, Tim Eisen, Athena Matakidou, Jason Gordon
Jul 17, 2020
Prognostic effect of cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma
Tobias Klatte, Kate Fife, Sarah J Welsh, Manavi Sachdeva, James N Armitage, Tevita 'Aho, Antony C Riddick, Athena Matakidou, Tim Eisen, Grant D Stewart
Feb 23, 2018
PURPOSE: To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS...
Nephrectomy Pazopanib Prognosis Sunitinib survival Aged Anilides Antibodies Monoclonal Antineoplastic Agents Carcinoma Renal Cell Cohort Studies Combined Modality Therapy Cytoreduction Surgical Procedures Female Humans Indazoles Indoles Kaplan-Meier Estimate Kidney Neoplasms Liver Neoplasms Lung Neoplasms Male Middle Aged Molecular Targeted Therapy Neoplasm Metastasis Nephrectomy Nivolumab Probability Prognosis Proportional Hazards Models Pyridines Pyrimidines Pyrroles Retrospective Studies Sex Factors Sulfonamides Sunitinib Survival Rate Thrombocytosis
Treatment patterns and health outcomes in metastatic renal cell carcinoma patients treated with targeted systemic therapies in the UK
Robert Hawkins, Kate Fife, Michael Hurst, Meng Wang, Niroshini Naicker, Sarah Nolasco, Tim Eisen, Athena Matakidou, Jason Gordon
Jul 28, 2021
Treatment patterns and health outcomes in metastatic renal cell carcinoma patients treated with targeted systemic therapies in the UK.
Robert Hawkins, Kate Fife, Michael Hurst, Meng Wang, Niroshini Naicker, Sarah Nolasco, Tim Eisen, Athena Matakidou, Jason Gordon
Oct 02, 2020
BACKGROUND: Patients with metastatic renal cell carcinoma (mRCC) treated with targeted systemic therapies have demonstrated favourable outcomes in randomised controlled trials, however real-world evidence is limited. Thus, this...
Molecular Targeted Therapy renal cancer Survival Analysis Adolescent Adult Aged Antineoplastic Agents Axitinib Carcinoma Renal Cell Everolimus Female Follow-Up Studies Humans Indazoles Kaplan-Meier Estimate Kidney Neoplasms Longitudinal Studies Male Middle Aged Molecular Targeted Therapy Practice Patterns Physicians' Prognosis Protein Kinase Inhibitors Pyrimidines Retrospective Studies Sulfonamides Sunitinib Treatment Outcome United Kingdom Young Adult
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
The use of error-category mapping in pharmacokinetic model analysis of dynamic contrast-enhanced MRI data.
Andrew B Gill, Gayathri Anandappa, Andrew J Patterson, Andrew N Priest, Martin J Graves, Tobias Janowitz, Duncan I Jodrell, Tim Eisen, David J Lomas
Feb 10, 2015
DCE-MRI error analysis metastatic renal cell carcinoma pharamacokinetic modeling REPEATABILITY Algorithms Antibodies Monoclonal Humanized Area Under Curve Bevacizumab Carcinoma Renal Cell Contrast Media Humans Image Processing Computer-Assisted Kidney Neoplasms Magnetic Resonance Imaging Models Theoretical Neoplasm Metastasis Reproducibility of Results Software
Multiparametric MRI for assessment of early response to neoadjuvant sunitinib in renal cell carcinoma.
Stephan Ursprung, Andrew N Priest, Fulvio Zaccagna, Wendi Qian, Andrea Machin, Grant Stewart, Anne Warren, Tim Eisen, Sarah Welsh, Ferdia Gallagher, Tristan Barrett
Oct 15, 2021
PURPOSE: To detect early response to sunitinib treatment in metastatic clear cell renal cancer (mRCC) using multiparametric MRI. METHOD: Participants with mRCC undergoing pre-surgical sunitinib therapy in the prospective NeoSun...
The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro
Rafia S. Al-Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen, Sarah J. Welsh, Antony C. P. Riddick, Fiach C. O’Mahony, Arran Turnbull, Thomas Powles, SCOTRRCC Collaborative SCOTRRCC Collaborative, Antonio Reverter, David J. Harrison, Grant D. Stewart
Apr 08, 2020
Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma (ccRCC), but their mechanism of action is not fully understood. Here, we...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Impact of COVID-19 pandemic on treatment patterns in metastatic clear cell renal cell carcinoma.
Stefanie Aeppli, Eric Innocents Eboulet, Tim Eisen, Bernard Escudier, Stefanie Fischer, James Larkin, Viktor Gruenwald, David McDermott, Jan Oldenburg, Aurelius Omlin, Camillo Porta, Brian Rini, Manuela Schmidinger, Cora Sternberg, Christian Rothermundt
Sep 15, 2020
BACKGROUND: The coronavirus pandemic has provoked discussions among healthcare providers how to manage cancer patients when faced with the threat of severe acute respiratory syndrome related coronavirus 2 (SARS-CoV-2) infection....
covid-19 decision criteria pandemic renal cell carcinoma treatment pattern Antineoplastic Agents Betacoronavirus covid-19 Carcinoma Renal Cell Clinical Decision-Making Coronavirus Infections Humans Immunologic Factors Kidney Neoplasms Medical Oncology Pandemics Pneumonia Viral Practice Patterns Physicians' Protein Kinase Inhibitors SARS-CoV-2 Urology
Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.
Dana Wai Yi Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong, Oscar M Rueda, Christopher G Smith, Dineika Chandrananda, Ross A Soo, Hong Liang Lim, Boon Cher Goh, Carlos Caldas, Tim Forshew, Davina Gale, Wei Liu, James Morris, Francesco Marass, Tim Eisen, Tan Min Chin, Nitzan Rosenfeld
Aug 15, 2018
Circulating tumour DNA Liquid biopsy Lung cancer resistance mechanisms targeted therapy Antineoplastic Agents Carcinoma Non-Small-Cell Lung DNA Copy Number Variations DNA Mutational Analysis DNA Neoplasm Drug Resistance Neoplasm ErbB Receptors Gefitinib Humans Hydroxychloroquine Longitudinal Studies Lung Neoplasms Mutation Prognosis Survival Analysis Treatment Outcome Tumor Suppressor Protein p53
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma.
Saiful E Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A Patel, M Nazhif Zaini, Johanna Burge, Anne Y Warren, Grant D Stewart, Tim Eisen, Dóra Bihary, Shamith A Samarajiwa, Sakari Vanharanta
Feb 21, 2019
Animals Carcinogenesis Carcinoma Renal Cell Cell Line Tumor Cell Proliferation Enhancer Elements Genetic Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks HEK293 Cells Humans Kidney Kidney Neoplasms Kruppel-Like Factor 6 Lipid Metabolism Male Mice Mice Inbred NOD Mice Nude Mice SCID Proto-Oncogene Proteins c-sis Signal Transduction Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 TOR Serine-Threonine Kinases Xenograft Model Antitumor Assays
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
bile salts Crohn's Disease Fatty Acids lipid-based formulation lipidomics luminal environment TIM-1 TNO /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
bile salts Crohn's Disease Fatty Acids lipid-based formulation lipidomics luminal environment TIM-1 TNO /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Factors Influencing Intention to Use Online Consumer Reviews
Online consumer reviews have been shown to play an important role that can influence consumers' attitudes, behaviors, and purchasing decisions. This study seeks to understand factors that affect user intention to use online...
Published by: IGI Global Scientific Publishing
The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma
Tobias Klatte, Kevin M. Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony C. P. Riddick, James N. Armitage, Tevita F. ‘Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J. Pantuck, Grant D. Stewart
Oct 02, 2020
Abstract: Background: The current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed...
Greenville Event Planned for Alumni Association's New President
Winthrop University
Jan 01, 0001
Magee, a Greenville, S.C., resident, replaces Tim Hopkins who was recently appointed to the Winthrop Board of Trustees as a designee for S.C. Governor Nikki Haley. The Alumni Association will host a reception welcoming Magee in...
Published by: Winthrop University
AUTHOR BOOK TALK
The Rockefeller University
Jan 01, 0001
Tim M. Berra: Wallace's Acceptance of Darwin's Priority in His Own Words
Published by: The Rockefeller University
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