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Results: 1493
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia
Alexander D Shaw, Laura E Hughes, Rosalyn Moran, Ian Coyle-Gilchrist, Tim Rittman, James B Rowe
Jun 27, 2019
The analysis of neural circuits can provide crucial insights into the mechanisms of neurodegeneration and dementias, and offer potential quantitative biological tools to assess novel therapeutics. Here we use behavioral variant...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Neurological update
Timothy Rittman
Oct 22, 2020
Abstract: Neuroimaging for dementia has made remarkable progress in recent years, shedding light on diagnostic subtypes of dementia, predicting prognosis and monitoring pathology. This review covers some updates in the...
Neurological update
Timothy Rittman
Jul 06, 2020
Neuroimaging for dementia has made remarkable progress in recent years, shedding light on diagnostic subtypes of dementia, predicting prognosis and monitoring pathology. This review covers some updates in the understanding of...
In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.
Maura Malpetti, Timothy Rittman, Peter Simon Jones, Thomas Edmund Cope, Luca Passamonti, William Richard Bevan-Jones, Karalyn Patterson, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Aug 27, 2020
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
bile salts Crohn's Disease Fatty Acids lipid-based formulation lipidomics luminal environment TIM-1 TNO /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
bile salts Crohn's Disease Fatty Acids lipid-based formulation lipidomics luminal environment TIM-1 TNO /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Factors Influencing Intention to Use Online Consumer Reviews
Online consumer reviews have been shown to play an important role that can influence consumers' attitudes, behaviors, and purchasing decisions. This study seeks to understand factors that affect user intention to use online...
Published by: IGI Global Scientific Publishing
Microglial activation and tau burden predict cognitive decline in Alzheimer's disease.
Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
May 18, 2020
Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's disease. Understanding whether these features predict cognitive decline, alone or in combination, is crucial to develop new prognostic...
Greenville Event Planned for Alumni Association's New President
Winthrop University
Jan 01, 0001
Magee, a Greenville, S.C., resident, replaces Tim Hopkins who was recently appointed to the Winthrop Board of Trustees as a designee for S.C. Governor Nikki Haley. The Alumni Association will host a reception welcoming Magee in...
Published by: Winthrop University
AUTHOR BOOK TALK
The Rockefeller University
Jan 01, 0001
Tim M. Berra: Wallace's Acceptance of Darwin's Priority in His Own Words
Published by: The Rockefeller University
Neurological update
Timothy Rittman
Jul 07, 2021
Abstract: Neuroimaging for dementia has made remarkable progress in recent years, shedding light on diagnostic subtypes of dementia, predicting prognosis and monitoring pathology. This review covers some updates in the...
Two New Board Members Added to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Tommy Pope and Tim Sease will join the Winthrop Board of Trustees in July. Pope has law enforcement and courtroom experience, while Sease oversees an investment company.
Published by: Winthrop University
In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.
Elijah Mak, Negin Holland, P Simon Jones, George Savulich, Audrey Low, Maura Malpetti, Sanne S Kaalund, Luca Passamonti, Timothy Rittman, Rafael Romero-Garcia, Roido Manavaki, Guy B Williams, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jan 25, 2021
Synaptic density in carriers of C9orf72 mutations
Maura Malpetti, Negin Holland, P Simon Jones, Rong Ye, Thomas E Cope, Tim D Fryer, Young T Hong, George Savulich, Timothy Rittman, Luca Passamonti, Elijah Mak, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jun 02, 2021
Falls in Progressive Supranuclear Palsy.
BACKGROUND: Despite falls being an almost universal clinical feature and central to the presentation and diagnostic criteria of progressive supranuclear palsy, our understanding of falls is surprisingly limited and there are few...
Improving response inhibition systems in frontotemporal dementia with citalopram.
Citalopram frontotemporal dementia Magnetoencephalography Response inhibition voxel-based morphometry Aged Citalopram Cross-Over Studies Double-Blind Method Electroencephalography Female Frontotemporal Dementia Humans INHIBITION Psychological Magnetic Resonance Imaging Magnetoencephalography Male Middle Aged Selective Serotonin Reuptake Inhibitors
American Party Event on Sept. 30 Features Co-Founder and U.S. Senate Candidate
Winthrop University
Jan 01, 0001
Jill Bossi of Tega Cay, South Carolina, is running for the U.S. Senate seat held by Tim Scott. Jim Rex, one of the American Party founders and a former S.C. education superintendent, will talk about creation of the party and...
Published by: Winthrop University
Progressive supranuclear palsy
Treating patients with progressive supranuclear palsy (PSP) is both effective and rewarding. This review aims to share our experience in the proactive management of PSP, considering the patient, the family and the medical...
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