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The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Reply to Sharp et al.
Sharp et al. (1) suggest that our original findings refute rather than support the effectiveness of psychological targeting (2, 3). We respectfully disagree for the following reasons.
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Promising Practices and Core (al) Innovation
Tim Sharp
Jan 30, 2014
Published by: Faculty of Education
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
Promising practices and core(al) innovation Plenary Keynote Presentation VII
Tim Sharp
Jan 31, 2014
Published by: Faculty of Education
Promising practices and core(al) innovation Plenary Keynote Presentation VII
Tim Sharp
Jan 31, 2014
Published by: Faculty of Education
Promising Practices and Core (al) Innovation
Tim Sharp
Jan 30, 2014
Published by: Faculty of Education
Transient computations using the natural stress formulation for solving sharp corner flows
In this short communication, we analyse the potential of the natural stress formulation (NSF) (i.e. aligning the stress basis along streamlines) for computing planar flows of an Oldroyd-B fluid around sharp corners. This is...
GPs' perceptions of advance care planning with frail and older people
BACKGROUND: Frail and older people are estimated to account for 40% of deaths. Despite conversations about end-of-life care being an important component of the national End of Life Care Strategy, there is a marked disparity...
Transient computations using the natural stress formulation for solving sharp corner flows
In this short communication, we analyse the potential of the natural stress formulation (NSF) (i.e. aligning the stress basis along streamlines) for computing planar flows of an Oldroyd-B fluid around sharp corners. This is...
Sharp high-frequency estimates for the Helmholtz equation and applications to boundary integral equations
We consider three problems for the Helmholtz equation in interior and
exterior domains in R^d, (d = 2, 3): the exterior Dirichlet-to-Neumann and Neumann-to-Dirichlet problems for outgoing solutions, and the interior...
exterior domains in R^d, (d = 2, 3): the exterior Dirichlet-to-Neumann and Neumann-to-Dirichlet problems for outgoing solutions, and the interior...
Sharp turns and gyrotaxis modulate surface accumulation of microorganisms.
The accumulation of swimming microorganisms at surfaces is an essential feature of various physical, chemical, and biological processes in confined spaces. To date, this accumulation is mainly assumed to depend on the change of...
Sex-independent senescence in a cooperatively breeding mammal.
Jack Thorley, Christopher Duncan, Stuart P Sharp, David Gaynor, Marta B Manser, Tim Clutton-Brock
Jan 22, 2020
Researchers studying mammals have frequently interpreted earlier or faster rates of ageing in males as resulting from polygyny and the associated higher costs of reproductive competition. Yet, few studies conducted on wild...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Sharp high-frequency estimates for the Helmholtz equation and applications to boundary integral equations
We consider three problems for the Helmholtz equation in interior and
exterior domains in R^d, (d = 2, 3): the exterior Dirichlet-to-Neumann and Neumann-to-Dirichlet problems for outgoing solutions, and the interior...
exterior domains in R^d, (d = 2, 3): the exterior Dirichlet-to-Neumann and Neumann-to-Dirichlet problems for outgoing solutions, and the interior...
Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location.
The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs...
Helmholtz-type regularization method for permittivity reconstruction using experimental phantom data of ECT
Electrical capacitance tomography (ECT) attempts to image the permittivity distribution of an object by measuring the electrical capacitance between sets of electrodes placed around its periphery. Image reconstruction in ECT is...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Sharp bounds on Helmholtz impedance-to-impedance maps and application to overlapping domain decomposition
We prove sharp bounds on certain impedance-to-impedance maps (and their compositions) for the Helmholtz equation with large wavenumber (i.e., at high frequency) using semiclassical defect measures. Gong et al. (Numer. Math....
Sharp Second-Order Pointwise Asymptotics for Lossless Compression with Side Information.
The problem of determining the best achievable performance of arbitrary lossless compression algorithms is examined, when correlated side information is available at both the encoder and decoder. For arbitrary source-side...
Helmholtz-type regularization method for permittivity reconstruction using experimental phantom data of ECT
Electrical capacitance tomography (ECT) attempts to image the permittivity distribution of an object by measuring the electrical capacitance between sets of electrodes placed around its periphery. Image reconstruction in ECT is...
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
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