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The basal ganglia in perceptual timing
The timing of perceptual events depends on an anatomically and functionally connected network comprising basal ganglia, cerebellum, pre-frontal cortex and supplementary motor area. Recent studies demonstrate the cerebellum to be...
Vortex shaking study of REBCO tape with consideration of anisotropic characteristics
The second generation high temperature superconductor, specifically REBCO, has become a new research focus in the development of a new generation of high-field (>25 T) magnets. One of the main challenges in the application of...
Vortex shaking study of REBCO tape with consideration of anisotropic characteristics
The second generation high temperature superconductor, specifically REBCO, has become a new research focus in the development of a new generation of high-field (>25 T) magnets. One of the main challenges in the application of...
Timing it right or timing it wrong
This article examines the challenges in designing income-tested benefits for people of working age. This is particularly difficult in the context of changing patterns of work and volatility in earnings and income. Matching...
Timing it right or timing it wrong
This article examines the challenges in designing income-tested benefits for people of working age. This is particularly difficult in the context of changing patterns of work and volatility in earnings and income. Matching...
Genomics of a Metamorphic Timing QT:
Very little is known about genetic factors that regulate life history transitions during ontogeny. Closely related tiger salamanders (Ambystoma species complex) show extreme variation in metamorphic timing, with some species...
Published by: Digital Commons @ Texas A&M University-San Antonio
Changing climate shifts timing of European floods
Gunter Bloschl, Julia Hall, Juray Parajka, Rui A. P. Perdigao, Bruno Merz, Berit Arheimer, Thomas Kjeldsen
Aug 11, 2017
A warming climate is expected to have an impact on the magnitude and timing of river floods; however, no consistent large-scale climate change signal in observed flood magnitudes has been identified so far. We analyzed the...
Genomics of a Metamorphic Timing QT:
Very little is known about genetic factors that regulate life history transitions during ontogeny. Closely related tiger salamanders (Ambystoma species complex) show extreme variation in metamorphic timing, with some species...
Published by: Digital Commons @ Texas A&M University-San Antonio
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.
Ben Hollis, Felix R Day, Alexander S Busch, Deborah J Thompson, Ana Luiza G Soares, Paul R H J Timmers, Alex Kwong, Doug F Easton, Peter K Joshi, Nicholas J Timpson, Ken K Ong, John R B Perry
Apr 30, 2020
The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait...
Published by: Nature Communications
Genomics of a Metamorphic Timing QT:
Very little is known about genetic factors that regulate life history transitions during ontogeny. Closely related tiger salamanders (Ambystoma species complex) show extreme variation in metamorphic timing, with some species...
Published by: Digital Commons @ Texas A&M University-San Antonio
Changing climate shifts timing of European floods
Gunter Bloschl, Julia Hall, Juray Parajka, Rui A. P. Perdigao, Bruno Merz, Berit Arheimer, Thomas Kjeldsen
Aug 11, 2017
A warming climate is expected to have an impact on the magnitude and timing of river floods; however, no consistent large-scale climate change signal in observed flood magnitudes has been identified so far. We analyzed the...
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
Ben Hollis, Felix R. Day, Alexander S. Busch, Deborah J. Thompson, Ana Luiza G. Soares, Paul R. H. J. Timmers, Alex Kwong, Doug F. Easton, Peter K. Joshi, Nicholas J. Timpson, Ken K. Ong, John R. B. Perry, Rosalind A. Eeles, Brian E. Henderson, Christopher A. Haiman, Zsofia Kote-Jarai, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Sonja I. Berndt, David V. Conti, Fredrik Wiklund, Stephen Chanock, Susan Gapstur, Victoria L. Stevens, Catherine M. Tangen, Jyotsna Batra, Judith Clements, Henrik Gronberg, Nora Pashayan, Johanna Schleutker, Demetrius Albanes, Alicja Wolk, Catharine West, Lorelei Mucci, Géraldine Cancel-Tassin, Stella Koutros, Karina Dalsgaard Sorensen, Eli Marie Grindedal, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ruth C. Travis, Robert J. Hamilton, Sue Ann Ingles, Barry S. Rosenstein, Yong-Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, Christiane Maier, Jeri Kim, Esther M. John, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago-Dominguez, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau, Wayne Tilley, Gail P. Risbridger, Lisa Horvath, Renea Taylor, Vanessa Hayes, Lisa Butler, Trina Yeadon, Allison Eckert, Pamela Saunders, Anne-Maree Haynes, Melissa Papargiris, Srilakshmi Srinivasan, Mary-Anne Kedda, Leire Moya, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, David A. Hinds, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson
Mar 24, 2021
Abstract: The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a...
Eclipse Timing the Milky Way's Gravitational Potential
We show that a small, but \textit{measurable} shift in the eclipse mid-point
time of eclipsing binary (EBs) stars of $\sim$ 0.1 seconds over a decade
baseline can be used to directly measure the Galactic acceleration of stars...
Price Shocks and Human Capital
The effect of economic shocks on human capital is theoretically ambiguous due to opposing income and substitution effects. Using child level information on schooling, child labour, and cognitive development, we investigate the...
Price Shocks and Human Capital
The effect of economic shocks on human capital is theoretically ambiguous due to opposing income and substitution effects. Using child level information on schooling, child labour, and cognitive development, we investigate the...
Tissue tectonics and the multi-scale regulation of developmental timing.
Development encompasses processes that occur at multiple length scales, including gene-regulatory interactions, cell movements and reorganization, cell signalling and growth. It is essential that the timing of events in all of...
Association of puberty timing with type 2 diabetes
Background: Emerging studies have investigated the association between puberty timing, particularly age at menarche (AAM), and type 2 diabetes. However, whether this association is independent of adiposity is unclear. We aimed...
Characterization of universal features of partially methylated domains across tissues and species.
Benjamin E Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon RV Knott, Gregory J Hannon, Andrew D Smith
Dec 14, 2020
BACKGROUND: Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, and cultured cell lines. Existing methods for deciding whether...
The genetic architecture of DNA replication timing in human pluripotent stem cells.
Qiliang Ding, Matthew M Edwards, Ning Wang, Xiang Zhu, Alexa N Bracci, Michelle L Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J Charvet, Sulagna Ghosh, Robert E Handsaker, Kevin Eggan, Florian T Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G Clark, Amnon Koren
Jan 07, 2022
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of replication timing, we exploited...
Pluripotent Stem Cells Humans Histones Transcription Factors DNA Methylation DNA Replication Timing Gene Expression Regulation Histone Code Acetylation Quantitative Trait Loci Genome Human Female Male Datasets as Topic whole genome sequencing Biological Variation Population
Published by: Nature Communications
Timing of the Sense of Volition in Patients With Schizophrenia.
Sarah Pirio Richardson, Antonio I Triggiani, Masao Matsuhashi, Valerie Voon, Elizabeth Peckham, Fatta Nahab, Zoltan Mari, Mark Hallett
Jan 11, 2021
Schizophrenic patients often do not have the sense that they direct their own movements or author their own thoughts (passivity phenomena). As willing must precede movement to be causal and thus generate the sense of agency, it...
From High School to the High Chair:
We exploit an expansion of post-compulsory schooling that occurred from the late 1980s to the early 1990s to investigate the effect of education on the timing of fertility in England and Wales. We do not find a significant...
Characterization of universal features of partially methylated domains across tissues and species
Benjamin E. Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R. V. Knott, Gregory J. Hannon, Andrew D. Smith
Oct 02, 2021
Abstract: Background: Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, and cultured cell lines. Existing methods for...
Is there a generalized timing impairment in Autism Spectrum Disorders across time scales and paradigms?
Sofia Isaksson, Susanna Salomäki, Jarno Tuominen, Valtteri Arstila, Christine M Falter-Wagner, Valdas Noreika
May 30, 2018
Individuals with ASD have abnormal motor and perceptual functions that do not currently form diagnostic criteria of ASD, but nevertheless may affect everyday behaviour. Temporal processing seems to be one of such non-diagnostic...
Characterization of universal features of partially methylated domains across tissues and species
Benjamin E. Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R. V. Knott, Gregory J. Hannon, Andrew D. Smith
Oct 02, 2020
Abstract: Background: Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, and cultured cell lines. Existing methods for...
Association of puberty timing with type 2 diabetes
BACKGROUND:Emerging studies have investigated the association between puberty timing, particularly age at menarche (AAM), and type 2 diabetes. However, whether this association is independent of adiposity is unclear. We aimed to...
Published by: PLoS Medicine
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