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Results: 26
Dub, Utopia and the Ruins of the Caribbean
The weathered stone, collapsed lintels and hollow roofs of the ruin have long evoked a sense of pathos, standing as monuments to the disastrous contours of history and the possibility of alternative futures. In this...
Joe PL Davidson
Jan 28, 2022
Interview with Willie T. "Dub" Massey - OH 138
Willie T. Massey
Jan 01, 0001
In his April 27th, 1981 interview with Phil O'Quinn, Rev. Willie T. "Dub" Massey recollects his involvement in the Civil Rights Movement as one of the Friendship 9 protestors and non-violent activists. Massey retells the...
Friendship nine Friendship 9 Grassroots movement sit-in non-violent protests Rock Hill McCrory's discrimination Segregation Jim Crow NAACP Jail No Bail law
Published by: Winthrop University
Real-Time Assessment of Health-Care Requirements During the Zika Virus Epidemic in Martinique.
Alessio Andronico, Frédérique Dorléans, Jean-Louis Fergé, Henrik Salje, Frédéric Ghawché, Aissatou Signate, Elise Daudens-Vaysse, Laure Baudouin, Timothée Dub, Maite Aubry, Van-Mai Cao-Lormeau, Martine Ledrans, Harold Noel, Henri-Pierre Mallet, Arnaud Fontanet, André Cabié, Simon Cauchemez
Feb 15, 2021
The spread of Zika virus in the Americas has been associated with a surge in Guillain-Barré syndrome (GBS) cases. Given the severity of GBS, territories affected by Zika virus need to plan health-care resources to manage GBS...
A priori bounds for rough differential equations with a non-linear damping term
We consider a rough differential equation with a non-linear damping drift term: dY(t)=−|Y|m−1Y(t)dt+σ(Y(t))dX(t), where X is a branched rough path of arbitrary regularity α>0, m>1 and where σ is smooth and satisfies an m...
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S Carroll, Andrew D Sharrocks
Apr 23, 2019
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function...
Winthrop Faculty, Staff and Students Turn Out to See Friendship Nine Vindicated
Winthrop University
Jan 01, 0001
The criminal charges of trespassing and protesting remained on the records of the nine - David Williamson, James Wells, Willie McCleod, Willie Thomas "Dub" Massey, Clarence Graham, John Gaines, Thomas Gaither, Mack Workman and...
Published by: Winthrop University
A priori bounds for rough differential equations with a non-linear damping term
We consider a rough differential equation with a non-linear damping drift term: dY(t)=−|Y|m−1Y(t)dt+σ(Y(t))dX(t), where X is a branched rough path of arbitrary regularity α>0, m>1 and where σ is smooth and satisfies an m...
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Jun 25, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
The role of selection and evolution in changing parturition date in a red deer population.
Timothée Bonnet, Michael B Morrissey, Alison Morris, Sean Morris, Tim H Clutton-Brock, Josephine M Pemberton, Loeske E B Kruuk
Dec 06, 2019
Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions...
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Jul 28, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
human Placenta trophoblast MOUSE trophoblast invasion developmental biology Stem Cells Epithelial-Mesenchymal Transition Regenerative Medicine stem cell self-renewal CRISPR gene editing
Published by: eLife
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Sep 05, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
CRISPR gene editing developmental biology Epithelial-Mesenchymal Transition human MOUSE Placenta Regenerative Medicine stem cell self-renewal Stem Cells trophoblast trophoblast invasion Animals Cell Differentiation Epithelial-Mesenchymal Transition Gene Expression Regulation Humans Mice Repressor Proteins Trophoblasts Tumor Suppressor Proteins Ubiquitin Thiolesterase
A swine arterivirus deubiquitinase stabilizes two major envelope proteins and promotes production of viral progeny.
Rui Guo, Xingyu Yan, Yanhua Li, Jin Cui, Saurav Misra, Andrew E Firth, Eric J Snijder, Ying Fang
Mar 18, 2021
Arteriviruses are enveloped positive-strand RNA viruses that assemble and egress using the host cell's exocytic pathway. In previous studies, we demonstrated that most arteriviruses use a unique -2 ribosomal frameshifting...
Connection probabilities for conformal loop ensembles
The goal of the present paper is to explain, based on properties of the conformal loop ensembles $\CLE_\kappa$ (both with simple and non-simple loops, i.e., for the whole range $\kappa \in (8/3, 8)$) how to derive the connection...
The role of selection and evolution in changing parturition date in a red deer population.
Timothée Bonnet, Michael B Morrissey, Alison Morris, Sean Morris, Tim H Clutton-Brock, Josephine M Pemberton, Loeske EB Kruuk
May 03, 2021
Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions...
Combining Analytical Approaches and Multiple Sources of Information to Improve Interpretation of Diagnostic Test Results for Tuberculosis in Wild Meerkats.
Stuart J Patterson, Charlene Clarke, Tim H Clutton-Brock, Michele A Miller, Sven DC Parsons, Dirk U Pfeiffer, Timothée Vergne, Julian A Drewe
Dec 22, 2021
Diagnostic tests are used to classify individual animals' infection statuses. However, validating test performance in wild animals without gold standard tests is extremely challenging, and the issue is further complicated in...
Transmission of highly pathogenic avian influenza in the nomadic free-grazing duck production system in Viet Nam.
Katriina Willgert, Anne Meyer, Dinh Xuan Tung, Nhu Van Thu, Pham Thanh Long, Scott Newman, Nguyen Thi Thanh Thuy, Pawin Padungtod, Guillaume Fournié, Dirk Udo Pfeiffer, Timothée Vergne
May 21, 2021
The presence of free-grazing ducks (FGD) has consistently been shown to be associated with highly pathogenic avian influenza virus (HPAIV) H5N1 outbreaks in South-East Asia. However, the lack of knowledge about the transmission...
Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.
Yun Hsiao Lin, Yue Liang, Hanchen Wang, Lin Tze Tung, Michael Förster, Poorani Ganesh Subramani, Javier M Di Noia, Simon Clare, David Langlais, Anastasia Nijnik
Jun 07, 2021
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important...
B Cell Development B cells epigenetic regulation Mouse models Transcriptional regulation Animals B-Lymphocytes Cell Lineage Cell Proliferation Cells Cultured Epigenesis Genetic Female Gene Expression Regulation Developmental Histones Lymphocyte Activation Male Mice Inbred C57BL Mice Knockout Phenotype Precursor Cells B-Lymphoid Protein Processing Post-Translational Transcription Genetic Tumor Suppressor Proteins Ubiquitin Thiolesterase Ubiquitination
Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster.
Protein ubiquitylation is a dynamic process that affects the function and stability of proteins and controls essential cellular processes ranging from cell proliferation to cell death. This process is regulated through the...
Phase Estimation of Local Hamiltonians on NISQ Hardware
Abstract
In this work we investigate a binned version of Quantum Phase Estimation (QPE) set out by [Som19] and known as the Quantum Eigenvalue Estimation Problem (QEEP)....
Molecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Mar 28, 2023
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular...
ovarian cancer Hereditary cancer Whole exome sequencing TCGA Fanci Fanconi Anemia Pathway Cancer Predisposing Gene Humans Ovarian Neoplasms Genetic Predisposition to Disease Molecular Biology Mutation Genes BRCA2 Female Fanconi Anemia Complementation Group Proteins
Published by: Genes
A ferroptosis-based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis.
David Devos, Caroline Moreau, Maeva Kyheng, Guillaume Garçon, Anne Sophie Rolland, Hélène Blasco, Patrick Gelé, T Timothée Lenglet, C Veyrat-Durebex, Philippe Corcia, Mary Dutheil, Peter Bede, Andreas Jeromin, Patrick Oeckl, Markus Otto, Vincent Meininger, Véronique Danel-Brunaud, Jean-Christophe Devedjian, James A Duce, Pierre François Pradat
Apr 09, 2019
Accurate patient stratification into prognostic categories and targeting Amyotrophic Lateral Sclerosis (ALS)-associated pathways may pave the way for promising trials. We evaluated blood-based prognostic indicators using an...
Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia MT Greenwood, Jiannis Ragoussis, Patricia N Tonin
Feb 03, 2023
Gauge-Underdetermination and Shades of Locality in the Aharonov–Bohm Effect
Ruward A. Mulder
Apr 09, 2021
Abstract: I address the view that the classical electromagnetic potentials are shown by the Aharonov–Bohm effect to be physically real (which I dub: ‘the potentials view’). I give a historico-philosophical presentation of this...
A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene.
Caitlin T Fierheller, Laure Guitton-Sert, Wejdan M Alenezi, Timothée Revil, Kathleen K Oros, Yuandi Gao, Karine Bedard, Suzanna L Arcand, Corinne Serruya, Supriya Behl, Liliane Meunier, Hubert Fleury, Eleanor Fewings, Deepak N Subramanian, Javad Nadaf, Jeffrey P Bruce, Rachel Bell, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Jacek Majewski, Trevor J Pugh, Marc Tischkowitz, Paul A James, Ian G Campbell, Celia MT Greenwood, Jiannis Ragoussis, Jean-Yves Masson, Patricia N Tonin
Dec 22, 2021
BACKGROUND: Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants...
Cancer-predisposing gene DNA Repair Fanci Familial aggregation of cancer Fanconi anaemia pathway Hereditary cancer ovarian cancer Protein expression Tissue microarray Whole exome sequencing BRCA1 Protein BRCA2 Protein Breast Neoplasms Canada Fanconi Anemia Complementation Group Proteins Female Genetic Predisposition to Disease Humans Male Ovarian Neoplasms
Gauge-Underdetermination and Shades of Locality in the Aharonov–Bohm Effect
Abstract I address the view that the classical electromagnetic potentials are shown by the Aharonov–Bohm effect to be physically real (which I dub: ‘the potentials view’). I give a...
Ruward A Mulder
May 03, 2021
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