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Regulation of regulatory T cells in cancer.
The inflammatory response to transformed cells forms the cornerstone of natural or therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known for their critical role in suppressing inflammation...
Context Dependent Role of Type 2 Innate Lymphoid Cells in Allergic Skin Inflammation.
David A Rafei-Shamsabadi, Christoph S N Klose, Timotheus Y F Halim, Yakup Tanriver, Thilo Jakob
Jan 03, 2020
The discovery of innate lymphoid cells (ILC) has profoundly influenced the understanding of innate and adaptive immune crosstalk in health and disease. ILC and T cells share developmental and functional characteristics such as...
Group 2 innate lymphocytes at the interface between innate and adaptive immunity.
Group 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell-to-cell interactions. As tissue-resident sentinels, ILC2 help orchestrate...
ILC2 T helper cells TH2 innate lymphoid cells type 2 response Adaptive Immunity Animals Cell Differentiation Cytokines Hormones Humans Immunity Innate Interleukins Lipids Lymphocyte Activation Lymphocyte Subsets Mice Models Immunological Neuroimmunomodulation Organ Specificity Receptors Immunologic Thymic Stromal Lymphopoietin
Context Dependent Role of Type 2 Innate Lymphoid Cells in Allergic Skin Inflammation.
David A Rafei-Shamsabadi, Christoph SN Klose, Timotheus YF Halim, Yakup Tanriver, Thilo Jakob
Jan 09, 2020
The discovery of innate lymphoid cells (ILC) has profoundly influenced the understanding of innate and adaptive immune crosstalk in health and disease. ILC and T cells share developmental and functional characteristics such as...
Desgarraduras del cuerpo y degolladuras de la voz
B Epps
Aug 24, 2017
El mismo mar de todos los veranos de Esther Tusquets narra la tormentosa relación erótica y emocional de una mujer de la alta burguesía catalana, casada y desencantada, que ejerce de profesora de literatura, con una joven...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Mar 09, 2021
Abstract: It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little...
G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.
Frann Antignano, Mitchell Braam, Michael R Hughes, Alistair L Chenery, Kyle Burrows, Matthew J Gold, Menno J Oudhoff, David Rattray, Timotheus Y Halim, Alissa Cait, Fumio Takei, Fabio M Rossi, Kelly M McNagny, Colby Zaph
Mar 27, 2018
Innate lymphoid cells (ILCs) are emerging as important regulators of homeostatic and disease-associated immune processes. Despite recent advances in defining the molecular pathways that control development and function of ILCs...
Juana Dib y el mahyar árabe-americano
Marcus S. Palmer
Apr 01, 2020
This paper investigates the thematic and aesthetic links between Juana Dib’s poetry with that of emigrant Mahjar writers. It evidences adaptations of perennial themes in Arabic poetry (nationalism, nostalgia, and memory) in...
Juana Dib El Mahyar poesía árabe-americano Latin American Literature Spanish and Portuguese Language and Literature
Published by: Digital Commons @ Texas A&M University-San Antonio
The Y Chromosome
The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex...
Y Chromosome Y haplogroups complex human traits complex locus genetic association analyses Genetic epidemiology Chromosomes Human Y Genetic Association Studies genetic variation Genetics Population Genome-Wide Association Study Haplotypes Humans Male Models Genetic molecular epidemiology Multifactorial Inheritance Quantitative Trait Loci Recombination Genetic Sex Determination Processes
Juana Dib y el mahyar árabe-americano
Marcus S. Palmer
Apr 01, 2020
This paper investigates the thematic and aesthetic links between Juana Dib’s poetry with that of emigrant Mahjar writers. It evidences adaptations of perennial themes in Arabic poetry (nationalism, nostalgia, and memory) in...
Juana Dib El Mahyar poesía árabe-americano Latin American Literature Spanish and Portuguese Language and Literature
Published by: Digital Commons @ Texas A&M University-San Antonio
Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.
David A Rafei-Shamsabadi, Saskia van de Poel, Britta Dorn, Stefanie Kunz, Stefan F Martin, Christoph SN Klose, Sebastian J Arnold, Yakup Tanriver, Karolina Ebert, Andreas Diefenbach, Timotheus YF Halim, Andrew NJ McKenzie, Thilo Jakob
Sep 05, 2018
Allergic contact dermatitis and its animal model, contact hypersensitivity, are T-cell-mediated inflammatory skin diseases that require activation of the innate immune system. Here we investigate the role of innate lymphoid...
Juana Dib y el mahyar árabe-americano
Marcus S. Palmer
Apr 01, 2020
This paper investigates the thematic and aesthetic links between Juana Dib’s poetry with that of emigrant Mahjar writers. It evidences adaptations of perennial themes in Arabic poetry (nationalism, nostalgia, and memory) in...
Juana Dib El Mahyar poesía árabe-americano Latin American Literature Spanish and Portuguese Language and Literature
Published by: Digital Commons @ Texas A&M University-San Antonio
How did the guppy Y chromosome evolve?
The sex chromosome pairs of many species do not undergo genetic recombination, unlike the autosomes. It has been proposed that the suppressed recombination results from natural selection favouring close linkage between...
The study of human Y chromosome variation through ancient DNA
T Kivisild
May 17, 2017
High throughput sequencing methods have completely transformed the study of human Y chromosome variation by offering a genome-scale view on genetic variation retrieved from ancient human remains in context of a growing number of...
How did the guppy Y chromosome evolve?
The sex chromosome pairs of many species do not undergo genetic recombination, unlike the autosomes. It has been proposed that the suppressed recombination results from natural selection favouring close linkage between...
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance.
Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan, Liam Cassidy, Marta Poblocka, Haoran Zhu, Aaron Lun, Martijn Schuijs, Andrew Young, Celia Martinez-Jimenez, Timotheus YF Halim, Shishir Shetty, Masashi Narita, Matthew Hoare
Jun 29, 2022
Colonización interna, cultura material y poder en el imperio inca
E DeMarrais
Aug 10, 2017
In Spanish
En este artículo se emplean perspectivas de la teoría postcolonial para entender la “experiencia discrepante” del personal imperial y de las poblaciones sujetas dentro del Imperio inca. El análisis de la cultura...
Mechanistic insights into non-coding Y RNA processing.
Martina Billmeier, Darrell Green, Adam E Hall, Carly Turnbull, Archana Singh, Ping Xu, Simon Moxon, Tamas Dalmay
May 01, 2022
Y RNAs (84-112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a...
An Antecedent Study of Mobile Social Game Addiction vs. Virtual Goods Purchase
This study aims to investigate how cognitive antecedents impact on social game addiction and virtual properties purchase among Generation Y players in Malaysia. Using a quantitative method with 341 Generation Y gamers and...
Published by: IGI Global Scientific Publishing
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.
Timotheus YF Halim, Batika MJ Rana, Jennifer A Walker, Bernhard Kerscher, Martin D Knolle, Helen E Jolin, Eva M Serrao, Liora Haim-Vilmovsky, Sarah A Teichmann, Hans-Reimer Rodewald, Marina Botto, Timothy J Vyse, Padraic G Fallon, Zhi Li, David R Withers, Andrew NJ McKenzie
Sep 05, 2018
Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia.
Michele Petruzzelli, Miriam Ferrer, Martijn J Schuijs, Sam O Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J Lukey, Duncan I Jodrell, Christian Frezza, Erwin F Wagner, Ashok R Venkitaraman, Timotheus YF Halim, Tobias Janowitz
Feb 17, 2022
An elevated neutrophil-lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer...
Structural and functional analysis of four non-coding Y RNAs from Chinese hamster cells
Quirino Alves de Lima Neto, Francisco Ferreira Duarte Junior, Paulo Sérgio Alves Bueno, Flavio Augusto Vicente Seixas, Madzia Pauline Kowalski, Eyemen Kheir, Torsten Krude, Maria Aparecida Fernandez
Sep 29, 2016
BACKGROUND: The genes coding for Y RNAs are evolutionarily conserved in vertebrates. These non-coding RNAs are essential for the initiation of chromosomal DNA replication in vertebrate cells. However thus far, no information is...
An 8.22 Mb Assembly and Annotation of the Alpaca (Vicugna pacos) Y Chromosome.
Matthew J Jevit, Brian W Davis, Caitlin Castaneda, Andrew Hillhouse, Rytis Juras, Vladimir A Trifonov, Ahmed Tibary, Jorge C Pereira, Malcolm A Ferguson-Smith, Terje Raudsepp
Apr 12, 2021
The unique evolutionary dynamics and complex structure make the Y chromosome the most diverse and least understood region in the mammalian genome, despite its undisputable role in sex determination, development, and male...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A Lazarus, Mona Shehata, Bruno M Simões, Alice R Greenhalgh, Sacha J Howell, Robert B Clarke, Carlos Caldas, Timotheus YF Halim, John C Marioni, Walid T Khaled
Feb 12, 2021
It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known...
Social Media Usage
Social media is an important part of young generations' digital lives and has become much more than a social connection tool. This research offers comprehensions into usage of social media among Gen Y and Gen Z and investigates...
Published by: IGI Global Scientific Publishing
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