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Error prevention and mitigation as forces in the evolution of genes and genomes
Why are short introns rarely a multiple of three nucleotides long? Why do essential genes cluster? Why are genes in operons often lined up in the order in which they are needed in the encoded pathway? In this Opinion article, we...
The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast
Coding sequence evolution was once thought to be the result of selection on optimal protein function alone. Selection can, however, also act at the RNA level, for example, to facilitate rapid translation or ensure correct...
Error prevention and mitigation as forces in the evolution of genes and genomes
Why are short introns rarely a multiple of three nucleotides long? Why do essential genes cluster? Why are genes in operons often lined up in the order in which they are needed in the encoded pathway? In this Opinion article, we...
The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast
Coding sequence evolution was once thought to be the result of selection on optimal protein function alone. Selection can, however, also act at the RNA level, for example, to facilitate rapid translation or ensure correct...
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.
Julie Borgel, Marek Tyl, Karin Schiller, Zsofia Pusztai, Christopher M Dooley, Wen Deng, Carol Wooding, Richard J White, Tobias Warnecke, Heinrich Leonhardt, Elisabeth M Busch-Nentwich, Till Bartke
Jun 20, 2018
Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their...
Animals Animals Genetically Modified Cell Line Chromobox Protein Homolog 5 Chromosomal Proteins Non-Histone CpG Islands Cricetinae DNA Methylation F-Box Proteins HEK293 Cells HeLa Cells Histones Humans Jumonji Domain-Containing Histone Demethylases Models Genetic Mutation Neoplasms Nucleosomes Protein Interaction Domains and Motifs Recombinant Fusion Proteins Two-Hybrid System Techniques Zebrafish Zinc Fingers
GroEL dependency affects codon usage-support for a critical role of misfolding in gene evolution
It has recently been suggested that the use of optimal codons limits mistranslation-induced protein misfolding, yet evidence for this remains largely circumstantial. In contrast, molecular chaperones have long been recognized to...
GroEL dependency affects codon usage-support for a critical role of misfolding in gene evolution
It has recently been suggested that the use of optimal codons limits mistranslation-induced protein misfolding, yet evidence for this remains largely circumstantial. In contrast, molecular chaperones have long been recognized to...
Finding exonic islands in a sea of non-coding sequence
Background: In mammals, splice-regulatory domains impose marked trends on the relative abundance of certain amino acids near exon-intron boundaries. Is this a mammalian particularity or symptomatic of exonic splicing regulation...
Measuring the conservation attitudes of local communities towards the African elephant Loxodonta africana, a flagship species in the Mara ecosystem.
Gaining insights into local people's views, values and preferences for different conservation management options are increasingly gaining importance among conservationists and decision-makers. This can be achieved through the...
Finding exonic islands in a sea of non-coding sequence
Background: In mammals, splice-regulatory domains impose marked trends on the relative abundance of certain amino acids near exon-intron boundaries. Is this a mammalian particularity or symptomatic of exonic splicing regulation...
A Question of Trust
Tobias Eberwein
Feb 16, 2018
Narrative forms of journalistic reporting are traded as a sheet anchor in many newsrooms, as editors hope that they could brave the never-ending storm of the media crisis. But how does journalistic storytelling evolve from...
Communication Studies Media and Communications Digital Communications Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
The Ursinus Weekly, November 8, 1907
Harvey B. Danehower, Jean Leroy Roth, Eva May Thompson, Harold Dean Steward, John Ellis Tobias
Jan 01, 0001
To tender the call Letter for the alumni Schubert string quartet Football Society Alumni notes Locals Seminary notes Literary Supplement: The Lack of Appreciation of the Beautiful; A Defense of American Poetry; The...
Ursinus College Collegeville Pennsylvania newspaper Albert Edwin Keigwin Football YMCA Schaff literary society Zwinglian literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Anxiety at 13 and its effect on pain, pain-related anxiety, and pain-related disability at 17
The aim of the present study was to investigate the influence of anxiety at 13 years of age on the presence of chronic pain, pain-related anxiety, and pain-related disability at 17 years of age in a large longitudinal cohort....
The Ursinus Weekly, November 1, 1907
Harvey B. Danehower, Evelyn A. Neff, Eva May Thompson, Harold Dean Steward, Victor J. Abel, John Ellis Tobias
Jan 01, 0001
Phantom party at Olevian Football Historical Political meeting The Schubert string quartette Editorial: Smiles Society Personals Seminary notes College world Alumni notes Literary Supplement: The lack of appreciation...
Ursinus College Collegeville Pennsylvania newspaper Football Halloween YMCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Anxiety at 13 and its effect on pain, pain-related anxiety, and pain-related disability at 17
The aim of the present study was to investigate the influence of anxiety at 13 years of age on the presence of chronic pain, pain-related anxiety, and pain-related disability at 17 years of age in a large longitudinal cohort....
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
Melanie Volke, Daniel P Gale, Ulrike Maegdefrau, Gunnar Schley, Bernd Klanke, Anja-Katrin Bosserhoff, Patrick H Maxwell, Kai-Uwe Eckardt, Christina Warnecke
Mar 18, 2019
BACKGROUND: Hepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores. Hypoxia and chemical stabilizers of the...
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Åsa Sjöling, Ann-Mari Svennerholm
Jun 25, 2018
The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea. Although 22 antigenically different colonization factors (CFs) have been identified and characterized in...
Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.
Celia L Gregson, Kenneth ES Poole, Eugene V McCloskey, Emma L Duncan, Jörn Rittweger, William D Fraser, George Davey Smith, Jonathan H Tobias
Oct 06, 2015
Adaptor Proteins Signal Transducing Adult Aged Aged 80 and over Bone Density Bone Morphogenetic Proteins Case-Control Studies Female Genetic Markers Humans Hyperostosis Low Density Lipoprotein Receptor-Related Protein-5 Male Middle Aged Mutation Osteochondrodysplasias Syndactyly United Kingdom Young Adult
Independent service operators in ATM markets
Tobias Wenzel
Feb 01, 2014
This paper studies the impact of entry of non-banks (termed Independent Service Operators, ISOs) into ATM markets. We compare two different regimes by which the ISO may generate income: (1) The ISO receives interchange fees...
Localized quantitative estimates and potential blow-up rates for Navier-Stokes equations
Tobias Barker
Oct 31, 2023
We show that if v is a smooth suitable weak solution to the Navier-Stokes equations on B(0, 4) \times (0,T*), which possesses a singular point (x0,T*) \in B(0, 4) \times \{ T*\} , then for all \delta > 0 sufficiently...
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