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'Jane Eyre' Stars Slowly Build Romance, Tension On Stage
Winthrop University
Jan 01, 0001
Show times are 8 p.m. Oct. 7-10 and 2 p.m. Oct. 11. If Winthrop University theatre majors Hunter Davis and Kevin Aoussou hear audience members asking, "When are they going to kiss?" during their production of "Jane Eyre," they...
Published by: Winthrop University
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma.
Stephen W Booth, Toby A Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R Middleton, Graham P Collins
Aug 26, 2021
Background
This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients...
Published by: BMC cancer
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma.
Stephen W Booth, Toby A Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R Middleton, Graham P Collins
Sep 24, 2021
BACKGROUND: This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients with...
Ibrutinib for mantle cell lymphoma at first relapse
Rory McCulloch, David Lewis, Nicola Crosbie, Toby A Eyre, Simon Bolam, Anita Arasaretnam, Thomas Creasey, Harshita Goradia, Annabel McMillan, Safia Dawi, Samuel Harrison, Oliver Miles, Andrew Robinson, David Dutton, Matthew R Wilson, Pam McKay, George Follows, Neil Phillips, Russell Patmore, Jonathan Lambert, Mark Bishton, Wendy Osborne, Rosalynd Johnston, Amy A Kirkwood, Simon Rule
Apr 16, 2021
clinical aspects ibrutinib mantle cell lymphoma post-ibrutinib outcomes adenine Adult Agammaglobulinaemia Tyrosine Kinase Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Bendamustine Hydrochloride Cytarabine Disease Progression Female Humans Lymphoma Mantle-Cell Male Middle Aged Outcome Assessment Health Care Piperidines Progression-Free Survival Protein Kinase Inhibitors Recurrence Retrospective Studies Rituximab State Medicine United Kingdom Withholding Treatment
Comparisons of Different Force Fields in Conformational Analysis and Searching of Organic Molecules
This review aims to examine literature where different force fields are compared by their performances in conformational analysis and searching of organic molecules. Conformational analysis studies are those where energies...
A microbiologically sensitive “intelligent” burns dressing concept
Rationale: Infection is the single largest contributor to increased morbidity and mortality in burns patients. Infection can often be difficult to diagnose against the background of generalised trauma. The problem of infection...
Development of a mixed-species biofilm model and its virulence implications in device related infections
It is becoming increasingly accepted that to understand and model the bacterial colonization and infection of abiotic surfaces requires the use of a biofilm model. There are many bacterial colonizations by at least two...
A microbiologically sensitive “intelligent” burns dressing concept
Rationale: Infection is the single largest contributor to increased morbidity and mortality in burns patients. Infection can often be difficult to diagnose against the background of generalised trauma. The problem of infection...
Milsom's Legal History
DJ Ibbetson
Jun 15, 2017
Toby Milsom was the most original English legal historian of the twentieth century. This paper gives a preliminary assessment of the importance of his work. charting the ways in which it has changed our thinking about the subject.
Effectiveness and cost-effectiveness of a very brief physical activity intervention delivered in NHS Health Checks (VBI Trial)
Joanna Mitchell, Wendy Hardeman, Sally Pears, Joana C Vasconcelos, A Toby Prevost, Ed Wilson, Stephen Sutton, VBI Research Team
Jun 13, 2018
BACKGROUND: Physical activity interventions that are targeted at individuals can be effective in encouraging people to be more physically active. However, most such interventions are too long or complex and not scalable to the...
Accelerometry Cost-effectiveness analysis Pedometer physical activity Primary Health Care randomised controlled trial Very brief intervention Actigraphy Cardiovascular Diseases Clinical Protocols Cost-Benefit Analysis England Exercise Fitness Trackers Health Behavior Health Care Costs health status Humans Patient Education as Topic Primary Health Care Primary Prevention Research Design Risk Reduction Behavior Self Care State Medicine Time Factors Treatment Outcome
An electrochemical impedance study of the effect of pathogenic bacterial toxins on tethered bilayer lipid membrane
Pathogenic bacteria secrete various virulence factors that can directly interact with the outer lipid bilayer membrane of eukaryotic cells, inducing cell death by apoptosis or necrosis. Such virulence factors account for much of...
Comparisons of Different Force Fields in Conformational Analysis and Searching of Organic Molecules
This review aims to examine literature where different force fields are compared by their performances in conformational analysis and searching of organic molecules. Conformational analysis studies are those where energies...
Screening for type 2 diabetes is feasible, acceptable, but associated with increased short-term anxiety
Adult Aged Anxiety Blood Glucose Diabetes mellitus Type 2 Family Practice Feasibility Studies Female health status Humans Male Mass Screening Middle Aged Outcome Assessment Health Care Patient Acceptance of Health Care Patient Participation Pilot Projects Program Evaluation Psychiatric Status Rating Scales Risk Factors Surveys and Questionnaires United Kingdom
A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media
Lloyd C. Murfin, Kirstie Chiang, George T. Williams, Catherine L. Lyall, A. Toby A. Jenkins, Jannis Wenk, Tony D. James, Simon E. Lewis
Jan 29, 2020
Colorimetry is an advantageous method for detecting fluoride in drinking water in a resource-limited context, e. g., in parts of the developing world where excess fluoride intake leads to harmful health effects. Here we...
Development of a mixed-species biofilm model and its virulence implications in device related infections
It is becoming increasingly accepted that to understand and model the bacterial colonization and infection of abiotic surfaces requires the use of a biofilm model. There are many bacterial colonizations by at least two...
A Colorimetric Chemosensor Based on a Nozoe Azulene That Detects Fluoride in Aqueous/Alcoholic Media
Lloyd C. Murfin, Kirstie Chiang, George T. Williams, Catherine L. Lyall, A. Toby A. Jenkins, Jannis Wenk, Tony D. James, Simon E. Lewis
Jan 29, 2020
Colorimetry is an advantageous method for detecting fluoride in drinking water in a resource-limited context, e. g., in parts of the developing world where excess fluoride intake leads to harmful health effects. Here we...
An electrochemical sensor concept for the detection of virulence factors from <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>
This work presents an electrochemical sensor concept for bacterial toxin detection using biomimetic lipid vesicles containing potassium ferricyanide. The toxin mediated release of redox couples from the vesicles was quantified...
Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules.
Seamless phase II/III clinical trials offer an efficient way to select an experimental treatment and perform confirmatory analysis within a single trial. However, combining the data from both stages in the final analysis can...
Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.
The problem of selection bias has long been recognized in the analysis of two-stage trials, where promising candidates are selected in stage 1 for confirmatory analysis in stage 2. To efficiently correct for bias, uniformly...
Optimisation of a lozenge-based sensor for detecting impending blockage of urinary catheters
Rachel A. Heylen, Max Branson, Lauren Gwynne, Bethany L. Patenall, Nina Hauschildt, James Urie, June Mercer-Chalmers, Naing T. Thet, Maisem Laabei, A. Toby A. Jenkins
Feb 01, 2022
Catheter-associated urinary tract infections resulting from urease-positive microorganisms are more likely to cause a urinary catheter blockage owing to the urease activity of the microbes. Catheter blockage can be dangerous...
Comparing the Performances of Force Fields in Conformational Searching of Hydrogen-Bond-Donating Catalysts
Here, we compare the relative performances of different force fields for conformational searching of hydrogen-bond-donating catalyst-like molecules. We assess the force fields by their predictions of conformer energies...
Nonlinear mixed-effects scalar-on-function models and variable selection
Abstract: This paper is motivated by our collaborative research and the aim is to model clinical assessments of upper limb function after stroke using 3D-position and 4D-orientation movement data. We present a new nonlinear...
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