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Continuous endocytic recycling of tight junction proteins
Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic...
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The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells
Tight junctions mediate the intercellular diffusion barrier found in epithelial tissues but they are not static complexes; instead there is rapid movement of individual proteins within the junctions. In addition some tight...
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Continuous endocytic recycling of tight junction proteins
Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic...
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Milsom's Legal History
DJ Ibbetson
Jun 15, 2017
Toby Milsom was the most original English legal historian of the twentieth century. This paper gives a preliminary assessment of the importance of his work. charting the ways in which it has changed our thinking about the subject.
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The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells
Tight junctions mediate the intercellular diffusion barrier found in epithelial tissues but they are not static complexes; instead there is rapid movement of individual proteins within the junctions. In addition some tight...
Published by:
Truncated RASSF7 promotes centrosomal defects and cell death

RASSF7 protein localises to the centrosome and plays a key role in mitosis. Its expression is also increased in a range of tumour types. However, little is known about the molecular basis of RASSF7's function and it is not...

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The MDCK variety pack
The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells. However, there are many different strains of MDCK cells available...
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Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species

α-Synuclein (α-syn) is a cytosolic protein known for its association with neurodegenerative diseases, including Parkinson's disease and other synucleinopathies. The potential cellular function of α-synuclein may be of...

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The MDCK variety pack
The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells. However, there are many different strains of MDCK cells available...
Published by:
Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species

α-Synuclein (α-syn) is a cytosolic protein known for its association with neurodegenerative diseases, including Parkinson's disease and other synucleinopathies. The potential cellular function of α-synuclein may be of...

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Psychosocial characteristics as potential predictors of suicide in adults
In this narrative overview of the evidence linking psychosocial factors with future suicide risk, we collected results from published reports of prospective studies with verified suicide events (mortality or, less commonly...
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Truncated RASSF7 promotes centrosomal defects and cell death

RASSF7 protein localises to the centrosome and plays a key role in mitosis. Its expression is also increased in a range of tumour types. However, little is known about the molecular basis of RASSF7's function and it is not...

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AI-Powered Tracking for Sustainable Marine Ecosystem Resource Management Projects
Ecosystems are our planet's life-support systems that facilitate sustainable development. Within the marine ecosystem, oysters serve as a keystone species. Numerous oyster restoration projects have been launched with a crucial...
Trajectory of Psychosocial Measures amongst Informal Caregivers
Informal caregivers provide vital support for older adults living in the community with chronic illnesses. The purpose of this study was to assess the psychosocial status of informal caregivers of community-dwelling adults over...
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Biocatalytic dearomatisation of para-fluorobenzoic acid
The enzyme benzoate dioxygenase (BZDO) from Ralstonia eutropha B9 is able to dihydroxylate benzoic acids in a dearomative process that proceeds with a different regioselectivity than other known dioxygenase enzymes. Here we show...
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