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Personalized and graph genomes reveal missing signal in epigenomic data
Abstract: Background: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human...
Personalized and graph genomes reveal missing signal in epigenomic data.
BACKGROUND: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome...
A Novel, Minimally Invasive, Paper-based Biomarker Assay for Molecular Diagnosis of Preeclampsia
Tomi Taiwo
Jan 01, 0001
Preeclampsia is a severe pregnancy condition marked by high blood pressure and proteinuria that can strike at any point throughout pregnancy or immediately after birth. Although the exact cause of this disease is unknown, there...
Analytical, Diagnostic and Therapeutic Techniques and Equipment Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diagnosis diseases Medicine and Health Sciences
Published by: Harrisburg University of Science and Technology
Contextualization of the Gospel in the Context of the Life of the Dani Tribe in Papua
Before the ascension of Jesus Christ into heaven, He gave the commandment, a Great Commission to preach the gospel to all nations. Dani tribe is one of the tribes in Papua and is certainly one of the objectives of the...
Published by: Indonesia Strategic Sustainability
Further Evidence for the Minifilament-eruption Scenario for Solar Polar Coronal Jets
Abstract
We examine a sampling of 23 polar-coronal-hole jets. We first identified the jets in soft X-ray (SXR) images from the X-ray telescope (XRT) on the Hinode spacecraft, over...
Cross-Sectional Associations of Objectively-Measured Physical Activity and Sedentary Time with Body Composition and Cardiorespiratory Fitness in Mid-Childhood
Paul J Collings, Kate Westgate, Juuso Väistö, Katrien Wijndaele, Andrew J Atkin, Eero A Haapala, Niina Lintu, Tomi Laitinen, Ulf Ekelund, Soren Brage, Timo A Lakka
Sep 19, 2016
Reactivity of Amorphous Carbon Surfaces
Systematic atomistic studies of surface reactivity for amorphous materials have not been possible in the past because of the complexity of these materials and the lack of the computer power necessary to draw representative...
Microcavity-like exciton-polaritons can be the primary photoexcitation in bare organic semiconductors.
Raj Pandya, Richard YS Chen, Qifei Gu, Jooyoung Sung, Christoph Schnedermann, Oluwafemi S Ojambati, Rohit Chikkaraddy, Jeffrey Gorman, Gianni Jacucci, Olimpia D Onelli, Tom Willhammar, Duncan N Johnstone, Sean M Collins, Paul A Midgley, Florian Auras, Tomi Baikie, Rahul Jayaprakash, Fabrice Mathevet, Richard Soucek, Matthew Du, Antonios M Alvertis, Arjun Ashoka, Silvia Vignolini, David G Lidzey, Jeremy J Baumberg, Richard H Friend, Thierry Barisien, Laurent Legrand, Alex W Chin, Joel Yuen-Zhou, Semion K Saikin, Philipp Kukura, Andrew J Musser, Akshay Rao
Jan 07, 2022
Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells.
Li Chen, Ruirui Yang, Tony Kwan, Chao Tang, Stephen Watt, Yiming Zhang, Guillaume Bourque, Bing Ge, Kate Downes, Mattia Frontini, Willem H Ouwehand, Jing-Wen Lin, Nicole Soranzo, Tomi Pastinen, Lu Chen
Nov 09, 2020
Microcavity-like exciton-polaritons can be the primary photoexcitation in bare organic semiconductors.
Raj Pandya, Richard YS Chen, Qifei Gu, Jooyoung Sung, Christoph Schnedermann, Oluwafemi S Ojambati, Rohit Chikkaraddy, Jeffrey Gorman, Gianni Jacucci, Olimpia D Onelli, Tom Willhammar, Duncan N Johnstone, Sean Collins, Paul Midgley, Florian Auras, Tomi Baikie, Rahul Jayaprakash, Fabrice Mathevet, Richard Soucek, Matthew Du, Antonios M Alvertis, Arjun Ashoka, Silvia Vignolini, David G Lidzey, Jeremy Baumberg, Richard Friend, Thierry Barisien, Laurent Legrand, Alex W Chin, Joel Yuen-Zhou, Semion K Saikin, Philipp Kukura, Andrew J Musser, Akshay Rao
Oct 15, 2021
Microcavity-like exciton-polaritons can be the primary photoexcitation in bare organic semiconductors
Raj Pandya, Richard Y. S. Chen, Qifei Gu, Jooyoung Sung, Christoph Schnedermann, Oluwafemi S. Ojambati, Rohit Chikkaraddy, Jeffrey Gorman, Gianni Jacucci, Olimpia D. Onelli, Tom Willhammar, Duncan N. Johnstone, Sean M. Collins, Paul A. Midgley, Florian Auras, Tomi Baikie, Rahul Jayaprakash, Fabrice Mathevet, Richard Soucek, Matthew Du, Antonios M. Alvertis, Arjun Ashoka, Silvia Vignolini, David G. Lidzey, Jeremy J. Baumberg, Richard H. Friend, Thierry Barisien, Laurent Legrand, Alex W. Chin, Joel Yuen-Zhou, Semion K. Saikin, Philipp Kukura, Andrew J. Musser, Akshay Rao
Nov 12, 2021
Abstract: Strong-coupling between excitons and confined photonic modes can lead to the formation of new quasi-particles termed exciton-polaritons which can display a range of interesting properties such as super-fluidity...
Role of ALD Al2O3 Surface Passivation on the Performance of p-Type Cu2O Thin Film Transistors.
Exploring rare and low-frequency variants in the Saguenay-Lac-Saint-Jean population identified genes associated with asthma and allergy traits.
Andréanne Morin, Anne-Marie Madore, Tony Kwan, Maria Ban, Jukka Partanen, Lars Rönnblom, Ann-Christine Syvänen, Stephen Sawcer, Hendrik Stunnenberg, Mark Lathrop, Tomi Pastinen, Catherine Laprise
Oct 03, 2018
The Saguenay-Lac-Saint-Jean (SLSJ) region is located in northeastern Quebec and is known for its unique demographic history and founder effect. As founder populations are enriched with population-specific variants, we...
Adolescent Adult Aged Aged 80 and over Asthma Child Child Preschool DNA-Binding Proteins Female Gene Frequency Humans Male Microtubule-Associated Proteins Middle Aged Mitochondrial Proteins Neuropilin-2 Polymorphism Single Nucleotide Quebec Receptors CXCR6 Ribosomal Proteins Serpin E2 Transcription Factors
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A Haapala, Tuomo T Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O Kilpeläinen, Tomi Laitinen, David E Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Oct 29, 2020
AIMS/HYPOTHESIS: We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly...
IFPA meeting 2018 workshop report II
Christiane Albrecht, Larry Chamley, D Stephen Charnock-Jones, Sally Collins, Hiroshi Fujiwara, Thaddeus Golos, Solene Grayo, Natalie Hannan, Lynda Harris, Kiyotake Ichizuka, Nicholas P Illsley, Mitsutoshi Iwashita, Sampada Kallol, Abdulla Al-Khan, Gendie Lash, Takeshi Nagamatsu, Akitoshi Nakashima, Kaoru Niimi, Masataka Nomoto, Christopher Redman, Shigeru Saito, Kenji Tanimura, Masatoshi Tomi, Hirokazu Usui, Manu Vatish, Bryce Wolfe, Eiko Yamamoto, Perrie O'Tierney-Ginn
Mar 25, 2019
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops...
Abnormally invasive placenta Drug delivery Gestational trophoblastic disease Infection Preeclampsia Animals Biomedical Research Drug Delivery Systems Education Female Gestational Trophoblastic Disease gynecology History 21st Century Humans Inflammation Japan Obstetrics Placenta Placenta Diseases pre-eclampsia Pregnancy Pregnancy Complications Infectious Societies Medical
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A. Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A. Haapala, Tuomo T. Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M. Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O. Kilpeläinen, Tomi Laitinen, David E. Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Sep 30, 2020
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A. Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A. Haapala, Tuomo T. Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M. Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O. Kilpeläinen, Tomi Laitinen, David E. Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Aug 26, 2021
Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project)
Matthias W Lorenz, Joseph F Polak, Maryam Kavousi, Ellisiv B Mathiesen, Henry Völzke, Tomi-Pekka Tuomainen, Dirk Sander, Matthieu Plichart, Alberico L Catapano, Christine M Robertson, Stefan Kiechl, Tatjana Rundek, Moïse Desvarieux, Lars Lind, Caroline Schmid, Pronabesh DasMahapatra, Lu Gao, Kathrin Ziegelbauer, Michiel L Bots, Simon G Thompson, PROG-IMT Study Group
Jun 10, 2019
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
Simone Ecker, Lu Chen, Vera Pancaldi, Frederik O Bagger, José M Fernández, Enrique Carrillo de Santa Pau, David Juan, Alice L Mann, Stephen Watt, Francesco P Casale, Nikos Sidiropoulos, Nicolas Rapin, Angelika Merkel, Hendrik G Stunnenberg, Oliver Stegle, Mattia Frontini, Kate Downes, Tomi Pastinen, Taco W Kuijpers, Daniel Rico, Alfonso Valencia, Stephan Beck, Nicole Soranzo, Dirk S Paul
Jan 27, 2017
Abstract
Background
A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and...
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.
Fiona Allum, Xiaojian Shao, Frédéric Guénard, Marie-Michelle Simon, Stephan Busche, Maxime Caron, John Lambourne, Julie Lessard, Karolina Tandre, Åsa K Hedman, Tony Kwan, Bing Ge, Multiple Tissue Human Expression Resource Consortium, Lars Rönnblom, Mark I McCarthy, Panos Deloukas, Todd Richmond, Daniel Burgess, Timothy D Spector, André Tchernof, Simon Marceau, Mark Lathrop, Marie-Claude Vohl, Tomi Pastinen, Elin Grundberg
Aug 04, 2015
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
Stephen Watt, Louella Vasquez, Klaudia Walter, Alice L. Mann, Kousik Kundu, Lu Chen, Ying Sims, Simone Ecker, Frances Burden, Samantha Farrow, Ben Farr, Valentina Iotchkova, Heather Elding, Daniel Mead, Manuel Tardaguila, Hannes Ponstingl, David Richardson, Avik Datta, Paul Flicek, Laura Clarke, Kate Downes, Tomi Pastinen, Peter Fraser, Mattia Frontini, Biola-Maria Javierre, Mikhail Spivakov, Nicole Soranzo
Apr 16, 2021
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease.
Stephen Watt, Louella Vasquez, Klaudia Walter, Alice L Mann, Kousik Kundu, Lu Chen, Ying Sims, Simone Ecker, Frances Burden, Samantha Farrow, Ben Farr, Valentina Iotchkova, Heather Elding, Daniel Mead, Manuel Tardaguila, Hannes Ponstingl, David Richardson, Avik Datta, Paul Flicek, Laura Clarke, Kate Downes, Tomi Pastinen, Peter Fraser, Mattia Frontini, Biola-Maria Javierre, Mikhail Spivakov, Nicole Soranzo
Jun 04, 2021
Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding...
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