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Results: 38
CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.
Tim Davies, Noriyuki Kodera, Gabriele S Kaminski Schierle, Eric Rees, Miklos Erdelyi, Clemens F Kaminski, Toshio Ando, Masanori Mishima
Feb 12, 2020
Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor subunit CYK4, plays important roles in cytokinesis. It is crucial for the formation of central spindle microtubule bundle structure. Its...
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the mechanism how MCs develop and cover ECs by...
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the mechanism how MCs develop and cover ECs by...
Comparison of Tied-Mixture and State-Clustered HMMs with Respect to Recognition Performance and Training Method
Tied-mixture HMMs have been proposed as the acoustic model for large-vocabulary continuous speech recognition and have yielded promising results. They share base-distribution and provide more flexibility in choosing the degree...
Published by: IGI Global Scientific Publishing
Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension
Ayako Chida-Nagai, Masaki Shintani, Hiroki Sato, Tomotaka Nakayama, Masaki Nii, Hiroyuki Akagawa, Toru Furukawa, Amer Rana, Yoshiyuki Furutani, Kei Inai, Shigeaki Nonoyama, Toshio Nakanishi
Mar 13, 2019
Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.
Robert Adalbert, Stefan Milde, Claire Durrant, Kunie Ando, Virginie Stygelbout, Zehra Yilmaz, Stacey Gould, Jean-Pierre Brion, Michael P Coleman
Jul 04, 2018
Alzheimer's Disease Axonal Transport Aβ FTDP-17T Mitochondria P301L mutation aging Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Axonal Transport Brain Disease Models Animal frontotemporal dementia Genetic Association Studies genetic variation Male Mice Inbred C57BL Mice Transgenic Mitochondria Mutation Plaque Amyloid tau Proteins
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
Jonathan Gilley, Kunie Ando, Anjan Seereeram, Teresa Rodríguez-Martín, Amy M Pooler, Laura Sturdee, Brian H Anderton, Jean-Pierre Brion, Diane P Hanger, Michael P Coleman
Jun 18, 2018
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. To investigate the involvement of tau phosphorylation in the pathological...
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus.
Hongjia Zhu, Masako Narita, Jerelle A Joseph, Georg Krainer, William E Arter, Ioana Olan, Kadi L Saar, Niklas Ermann, Jorge R Espinosa, Yi Shen, Masami Ando Kuri, Runzhang Qi, Timothy J Welsh, Rosana Collepardo-Guevara, Masashi Narita, Tuomas PJ Knowles
Nov 30, 2022
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Terumasa Umemoto, Keiyo Takubo, Hitoshi Takizawa, Susumu Goyama, Yasushi Ishihama, Hiroaki Honda, Berthold Göttgens, Toshio Kitamura
Dec 16, 2019
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between "dormant" and "active" HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line...
CDK G(0) phase HSC Calcium Cell Cycle dormancy Hematopoietic stem cell p27 Animals Biomarkers Calcium Cell Proliferation Cell Self Renewal Cytoplasm Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Hematopoietic Stem Cells Male Mice Mice Inbred C57BL Resting Phase Cell Cycle Single-Cell Analysis
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W Wingett, Peter Fraser
Jul 28, 2021
Background
Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still...
Transcription regulation circadian rhythms Enhancers TADs Circadian gene expression Chromatin compartments Genome 3D organization Promoter interactions
Published by: Genome biology
Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.
Munyaradzi Dimairo, Elizabeth Coates, Philip Pallmann, Susan Todd, Steven A Julious, Thomas Jaki, James Wason, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Katie Biggs, Jon Nicholl, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman
Dec 17, 2018
BACKGROUND: Adequate reporting of adaptive designs (ADs) maximises their potential benefits in the conduct of clinical trials. Transparent reporting can help address some obstacles and concerns relating to the use of ADs....
A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors.
Isabella Orienti, Federica Francescangeli, Maria Laura De Angelis, Katia Fecchi, Lucilla Bongiorno-Borbone, Michele Signore, Angelo Peschiaroli, Alessandra Boe, Alessandro Bruselles, Angelita Costantino, Adriana Eramo, Valentina Salvati, Giovanni Sette, Paola Contavalli, Lello Zolla, Toshihiko Oki, Toshio Kitamura, Massimo Spada, Alessandro Giuliani, Marta Baiocchi, Filippo La Torre, Gerry Melino, Marco Tartaglia, Ruggero De Maria, Ann Zeuner
Sep 10, 2019
Fenretinide is a synthetic retinoid characterized by anticancer activity in preclinical models and favorable toxicological profile, but also by a low bioavailability that hindered its clinical efficacy in former clinical trials....
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G. Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A. César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W. Wingett, Peter Fraser
Jun 08, 2021
The adaptive designs CONSORT extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jun 17, 2021
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W Wingett, Peter Fraser
Jul 29, 2021
BACKGROUND: Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under...
Chromatin compartments Circadian gene expression circadian rhythms Enhancers Genome 3D organization Promoter interactions TADs Transcription regulation Animals Base Sequence Biological Clocks Chromatin Circadian Rhythm Enhancer Elements Genetic Gene Expression Regulation Genome Liver Male Mice Inbred C57BL Models Genetic Promoter Regions Genetic Time Factors Transcription Genetic
The Adaptive designs CONSORT Extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jul 01, 2020
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
Role of p73 in Alzheimer disease
Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway
Apr 02, 2013
Aged Aged 80 and over Alzheimer Disease Animals Benzofurans Blotting Western DNA-Binding Proteins Disease Models Animal Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Immunohistochemistry Male Mice Mice Transgenic Nuclear Proteins Polymorphism Single Nucleotide Quinolines Tumor Protein p73 Tumor Suppressor Proteins tau Proteins
The relapsing polychondritis damage index (RPDAM)
Philippe Mertz, Alexandre Belot, Ricard Cervera, Tyng Yu Chuah, Lorenzo Dagna, Laura Damian, Debashish Danda, David D'Cruz, Gerard Espinosa, Camille Frances, David Jayne, Kong Kok Ooi, Eugene J Kucharz, Robert Lebovics, Isabelle Marie, Guillaume Moulis, Stanford Peng, Aman Sharma, Noboru Suzuki, Toshio Tanaka, Ronald Van Vollenhoven, Jean Sibilia, Jacques Eric Gottenberg, François Chasset, Laurent Arnaud
Mar 06, 2020
OBJECTIVES: Relapsing polychondritis is a rare, multi-systemic and inflammatory condition of unknown origin. We currently lack a core set of measures to assess and follow damage in patients suffering from this condition. Our...
autoinflammatory diseases Damage index Relapsing polychondritis Adult Age Factors Cohort Studies Consensus Delphi Technique Disability Evaluation Expert Testimony Female Humans Internationality Male Middle Aged Polychondritis Relapsing Reproducibility of Results Risk Assessment Severity of Illness Index Sex Factors
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S Kotecha, Mark N Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Sep 30, 2022
The adaptive designs CONSORT extension (ACE) statement
Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A. Julious, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Jon P. Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott, Yuki Ando, Daniel Hind, Douglas G. Altman, Munyaradzi Dimairo, Jon Nicholl, William J. Meurer, Christopher Cates, Matthew Sydes, Yannis Jemiai, Deborah Ashby, Christina Yap, Frank Waldron-Lynch, James Roger, Joan Marsh, Olivier Collignon, David J. Lawrence, Catey Bunce, Tom Parke, Gus Gazzard, Sally Hopewell
Jun 17, 2020
Abstract: Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The...
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