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Results: 136
Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
Apr 21, 2022
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and...
From Models-as-Fictions to Models-as-Tools
Adrian Currie
Jan 15, 2018
Many accounts of scientific modeling conceive of models as fictions: scientists interact with models in ways analogous to various aesthetic objects. Fictionalists follow most other accounts of modeling by taking them to be...
Bottled Understanding
Adrian Currie
Jan 09, 2019
It is often thought that the vindication of experimental work lies in its capacity to be revelatory of natural systems. I challenge this idea by examining laboratory experiments in ecology. A central task of community ecology...
Uniqueness in the life sciences
Abstract: Researchers in the life sciences often make uniqueness attributions; about branching events generating new species, the developmental processes generating novel traits and the distinctive cultural selection pressures...
A versatile and fully instrumented test station for piezoelectric energy harvesters
This paper describes the implementation of LabVIEW software to control instruments and acquire data from a piezoelectric energy harvesting test station which is based on a cantilever structure. The experiment is run in the...
Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
May 09, 2022
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and...
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution
Abstract: Background: Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain...
Uniqueness in the life sciences
Abstract Researchers in the life sciences often make uniqueness attributions; about branching events generating new species, the developmental processes generating novel traits and the distinctive...
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.
Background
Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain...
Published by: BMC biology
Accelerating the carbon cycle
Enhanced weathering, in comparison to other geoengineering measures, creates the possibility of a reduced cost, reduced impact way of decreasing atmospheric carbon, with positive knock-on effects such as decreased oceanic...
Institutional Complexity and Individual Responses
Research highlights how coexisting institutional logics can sometimes offer opportunities for agency to enterprising actors in organizational fields. But macro- and micro-level studies using this framework diverge in their...
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.
BACKGROUND: Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain these...
The first oviraptorosaur (Dinosauria Theropoda) bonebed
Gregory F. Funston, Philip J. Currie, David A. Eberth, Michael J. Ryan, Tsogtbaatar Chinzorig, Demchig Badamgarav, Nicholas R. Longrich
Jan 01, 0001
A monodominant bonebed of Avimimus from the Nemegt Formation of Mongolia is the first oviraptorosaur bonebed described and the only recorded maniraptoran bonebed from the Late Cretaceous. Cranial elements recovered from the...
The first oviraptorosaur (Dinosauria Theropoda) bonebed
Gregory F. Funston, Philip J. Currie, David A. Eberth, Michael J. Ryan, Tsogtbaatar Chinzorig, Demchig Badamgarav, Nicholas R. Longrich
Jan 01, 0001
A monodominant bonebed of Avimimus from the Nemegt Formation of Mongolia is the first oviraptorosaur bonebed described and the only recorded maniraptoran bonebed from the Late Cretaceous. Cranial elements recovered from the...
A versatile and fully instrumented test station for piezoelectric energy harvesters
This paper describes the implementation of LabVIEW software to control instruments and acquire data from a piezoelectric energy harvesting test station which is based on a cantilever structure. The experiment is run in the...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Feb 09, 2023
BACKGROUND: While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service (SMS)...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Mar 13, 2023
Background
While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service...
Vaccination Reminder Systems SMS mHealth Text Messaging Childhood immunisation Humans Bayes Theorem Child Australia Randomized Controlled Trials as Topic Vaccination Coverage Cell Phone
Published by: Trials
Burkholderia pseudomallei genome plasticity associated with genomic island variation
S Tumapa, M T G Holden, M Vesaratchavest, V Wuthiekanun, D Limmathurotsakul, W Chierakul, E J Feil, B J Currie, N P J Day, W C Nierman, S J Peacock
Apr 25, 2008
Background: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an important determinant of virulence...
Burkholderia pseudomallei genome plasticity associated with genomic island variation
S Tumapa, M T G Holden, M Vesaratchavest, V Wuthiekanun, D Limmathurotsakul, W Chierakul, E J Feil, B J Currie, N P J Day, W C Nierman, S J Peacock
Apr 25, 2008
Background: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an important determinant of virulence...
Pricing policies and control of tobacco in Europe (PPACTE) project
Silviano Gallus, Alessandra Lugo, Carlo La Vecchia, Paolo Boffetta, Frank J Chaloupka, Paolo Colombo, Laura Currie, Esteve Fernandez, Colin Fischbacher, Anna Gilmore, Fiona Godfrey, Luk Joossens, Maria E Leon, David T Levy, Lien Nguyen, Gunnar Rosenqvist, Hana Ross, Joy Townsend, Luke Clancy
May 01, 2014
Limited data on smoking prevalence allowing valid between-country comparison are available in Europe. The aim of this study is to provide data on smoking prevalence and its determinants in 18 European countries. In 2010, within...
Pricing policies and control of tobacco in Europe (PPACTE) project
Silviano Gallus, Alessandra Lugo, Carlo La Vecchia, Paolo Boffetta, Frank J Chaloupka, Paolo Colombo, Laura Currie, Esteve Fernandez, Colin Fischbacher, Anna Gilmore, Fiona Godfrey, Luk Joossens, Maria E Leon, David T Levy, Lien Nguyen, Gunnar Rosenqvist, Hana Ross, Joy Townsend, Luke Clancy
May 01, 2014
Limited data on smoking prevalence allowing valid between-country comparison are available in Europe. The aim of this study is to provide data on smoking prevalence and its determinants in 18 European countries. In 2010, within...
Global and regional dissemination and evolution of $\textit{Burkholderia pseudomallei}$
C Chewapreecha, MTG Holden, M Vehkala, N Välimäki, Z Yang, SR Harris, AE Mather, A Tuanyok, B De Smet, S Le Hello, C Bizet, M Mayo, V Wuthiekanun, D Limmathurotsakul, R Phetsouvanh, BG Spratt, J Corander, P Keim, G Dougan, DAB Dance, BJ Currie, J Parkhill, SJ Peacock
Mar 06, 2017
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