Search
Results: 381
James Croll and geological archives
ABSTRACT James Croll's Physical Theory of Secular Changes of Climate emerged during an age of revolution in geology that included the rise of the glacial theory and the search for its underlying...
Transgender Genealogy in Tristan de Nanteuil
B Gutt
Aug 29, 2018
This article proposes the use of transgender theory within medieval studies as both a productive and a politically significant optic. The article employs transgender theory to effect a new reading of the miraculous...
ISOLDE
Tristan Ian Croll
Jun 14, 2018
This paper introduces ISOLDE, a new software package designed to provide an intuitive environment for high-fidelity interactive remodelling/refinement of macromolecular models into electron-density maps. ISOLDE combines...
Adaptive Cartesian and torsional restraints for interactive model rebuilding.
When building atomic models into weak and/or low-resolution density, a common strategy is to restrain their conformation to that of a higher resolution model of the same or similar sequence. When doing so, it is important to...
Improving SARS-CoV-2 structures
Tristan I Croll, Christopher J Williams, Vincent B Chen, David C Richardson, Jane S Richardson
Feb 03, 2021
This work builds upon the record-breaking speed and generous immediate release of new experimental three-dimensional structures of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and complexes, which...
‘The most remarkable man’
Kevin J Edwards
Apr 04, 2022
ABSTRACT: The year 2021 marked the bicentenary of the birth of James Croll (1821–1890), the self‐educated son of a crofter‐stonemason, whose life was characterised by a dizzying range of occupations and homes, poor health and...
Evaluation of template-based modeling in CASP13.
Performance in the template-based modeling (TBM) category of CASP13 is assessed here, using a variety of metrics. Performance of the predictor groups that participated is ranked using the primary ranking score that was developed...
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE.
Robert D Oeffner, Tristan I Croll, Claudia Millán, Billy K Poon, Christopher J Schlicksup, Randy J Read, Tom C Terwilliger
Oct 27, 2022
AlphaFold has recently become an important tool in providing models for experimental structure determination by X-ray crystallography and cryo-EM. Large parts of the predicted models typically approach the accuracy of...
Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain.
Jialiang Wang, Dandan Li, Lu Chen, Wei Cao, Liangliang Kong, Wei Zhang, Tristan Croll, Zixin Deng, Jingdan Liang, Zhijun Wang
Mar 05, 2022
Nonribosomal peptide synthetases (NRPSs) are modular assembly-line megaenzymes that synthesize diverse metabolites with wide-ranging biological activities. The structural dynamics of synthetic elongation has remained unclear....
Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.
BTB–Kelch E3 ubiquitin ligase X-ray crystallography immunosuppression innate immunity isothermal titration calorimetry (ITC) Poxvirus Protein Structure structure-function viral immunology Amino Acid Substitution Cullin Proteins HEK293 Cells Humans Multiprotein Complexes Mutation Missense Protein Domains Protein Structure Quaternary Proteolysis Ubiquitination Vaccinia vaccinia virus Viral Proteins
Cryo-EM Structure of the Rhodobacter sphaeroides Light-Harvesting 2 Complex at 2.1 Å
Pu Qian, David JK Swainsbury, Tristan I Croll, Pablo Castro-Hartmann, Giorgio Divitini, Kasim Sader, C Neil Hunter
Oct 29, 2021
Light-harvesting 2 (LH2) antenna complexes augment the collection of solar energy in many phototrophic bacteria. Despite its frequent role as a model for such complexes, there has been no three-dimensional (3D) structure...
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE.
Robert D Oeffner, Tristan I Croll, Claudia Millán, Billy K Poon, Christopher J Schlicksup, Randy J Read, Tom C Terwilliger
Dec 08, 2022
AlphaFold has recently become an important tool in providing models for experimental structure determination by X-ray crystallography and cryo-EM. Large parts of the predicted models typically approach the accuracy of...
Phasertng
Airlie J McCoy, Duncan H Stockwell, Massimo D Sammito, Robert D Oeffner, Kaushik S Hatti, Tristan I Croll, Randy J Read
Jan 25, 2021
Crystallographic phasing strategies increasingly require the exploration and ranking of many hypotheses about the number, types and positions of atoms, molecules and/or molecular fragments in the unit cell, each with only a...
UCSF ChimeraX
Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Elaine C Meng, Gregory S Couch, Tristan I Croll, John H Morris, Thomas E Ferrin
Sep 07, 2020
UCSF ChimeraX is the next‐generation interactive visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX brings (i) significant performance and graphics...
Cryo-EM structure of the Rhodospirillum rubrum RC-LH1 complex at 2.5 Å.
Pu Qian, Tristan I Croll, David JK Swainsbury, Pablo Castro-Hartmann, Nigel W Moriarty, Kasim Sader, C Neil Hunter
Nov 10, 2021
The reaction centre light-harvesting 1 (RC-LH1) complex is the core functional component of bacterial photosynthesis. We determined the cryo-electron microscopy (cryo-EM) structure of the RC-LH1 complex from Rhodospirillum...
Carotenoids cryo-electron microscopy light-harvesting Photosynthesis Quinone reaction centre Bacterial Proteins Bacteriochlorophylls Benzoquinones Binding Sites Cryoelectron Microscopy Crystallization Electron Transport Complex III Hydrogen Bonding Hydroquinones Ligands Light-Harvesting Protein Complexes Phospholipids Protein Conformation alpha-Helical Rhodospirillum rubrum
Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane
Hyeonuk Woo, Sang-Jun Park, Yeol Kyo Choi, Taeyong Park, Maham Tanveer, Yiwei Cao, Nathan R Kern, Jumin Lee, Min Sun Yeom, Tristan Ian Croll, Chaok Seok, Wonpil Im
Jun 23, 2020
This technical studydescribes all-atom modeling and simulation of a fully-glycosylated full-length SARS-CoV-2 spike (S) proteinin a viral membrane. First, starting from PDB:6VSBand 6VXX, full-length S protein structures were...
Cryo-EM structures of light-harvesting 2 complexes from Rhodopseudomonas palustris reveal the molecular origin of absorption tuning.
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.
Lionel Rougé, Nancy Chiang, Micah Steffek, Christine Kugel, Tristan I Croll, Christine Tam, Alberto Estevez, Christopher P Arthur, Christopher M Koth, Claudio Ciferri, Edward Kraft, Jian Payandeh, Gerald Nakamura, James T Koerber, Alexis Rohou
Dec 09, 2020
Cluster of differentiation 20 (CD20) is a B cell membrane protein that is targeted by monoclonal antibodies for the treatment of malignancies and autoimmune disorders but whose structure and function are unknown. Rituximab (RTX)...
How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Yibin Xu, Nicholas S Kirk, Hariprasad Venugopal, Mai B Margetts, Tristan I Croll, Jarrod J Sandow, Andrew I Webb, Carlie A Delaine, Briony E Forbes, Michael C Lawrence
May 11, 2020
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via...
Cryoelectron Microscopy Insulin-Like Growth Factor I Insulin-Like Growth Factor II leucine zipper single-particle 3D reconstruction type 1 insulin-like growth factor receptor 3T3 Cells Animals Binding Sites CHO Cells Cricetinae Cricetulus Cryoelectron Microscopy Humans Insulin-Like Growth Factor II Mice Molecular Docking Simulation Protein Binding Receptor IGF Type 1
Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane.
Yeol Kyo Choi, Yiwei Cao, Martin Frank, Hyeonuk Woo, Sang-Jun Park, Min Sun Yeom, Tristan I Croll, Chaok Seok, Wonpil Im
Mar 02, 2021
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is considered the major target for drug and vaccine...
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins.
Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren GF Rasmussen, Magnus Andersson, Tristan Croll, Kamil Gotfryd, Pontus Gourdon
Aug 19, 2022
Zinc is essential for all organisms and yet detrimental at elevated levels. Hence, homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the only zinc importers in metazoans. Mutations in...
|
|< |
< |
1 |