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ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma.
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma.
Marina Georgiou, Panagiota Ntavelou, William Stokes, Rajat Roy, Geoffrey J Maher, Tsvetana Stoilova, Josephine AMY Choo, Callum P Rakhit, Miguel Martins, Paul Ajuh, Neil Horowitz, Ross S Berkowitz, Kevin Elias, Michael J Seckl, Olivier E Pardo
Jun 07, 2022
Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation.
Bettina Meier, Nadezda V Volkova, Ye Hong, Simone Bertolini, Víctor González-Huici, Tsvetana Petrova, Simon Boulton, Peter J Campbell, Moritz Gerstung, Anton Gartner
Apr 27, 2021
Maintaining genome integrity is particularly important in germ cells to ensure faithful transmission of genetic information across generations. Here we systematically describe germ cell mutagenesis in wild-type and 61 DNA repair...
Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Proliferation Chromosome Mapping DNA Damage DNA Helicases DNA Repair DNA Replication DNA Helminth DNA-Directed DNA Polymerase Deoxyribonucleases Endonucleases Gene Expression Regulation Genome Helminth Germ Cells Isoenzymes Mutation Rad51 Recombinase
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
Dimitris Karamitros, Bilyana Stoilova, Zahra Aboukhalil, Fiona Hamey, Andreas Reinisch, Marina Samitsch, Lynn Quek, Georg Otto, Emmanouela Repapi, Jessica Doondeea, Batchimeg Usukhbayar, Julien Calvo, Stephen Taylor, Nicolas Goardon, Emmanuelle Six, Francoise Pflumio, Catherine Porcher, Ravindra Majeti, Berthold Göttgens, Paresh Vyas
Nov 06, 2017