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Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales
Through advances in the past decades, the central role of aberrant protein aggregation has been established in many neurodegenerative diseases. Crucially, however, the molecular mechanisms that underlie aggregate proliferation...
Sequential storage and release of microdroplets.
Droplet microfluidic methods have opened up the possibility of studying a plethora of phenomena ranging from biological to physical or chemical processes at ultra low volumes and high throughput. A key component of such...
Sequential storage and release of microdroplets.
Droplet microfluidic methods have opened up the possibility of studying a plethora of phenomena ranging from biological to physical or chemical processes at ultra low volumes and high throughput. A key component of such...
Published by: Microsystems & nanoengineering
Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels.
Microcapsules and microgels consisting of macromolecular networks have received increasing attention due to their biomedical and pharmaceutical applications. Protein microgels and in particular silk-based microcapsules have...
Microfluidic approaches for the analysis of protein-protein interactions in solution.
Exploration and characterisation of the human proteome is a key objective enabling a heightened understanding of biological function, malfunction and pharmaceutical design. Since proteins typically exhibit their behaviour by...
Attoliter protein nanogels from droplet nanofluidics for intracellular delivery.
Microscale hydrogels consisting of macromolecular networks in aqueous continuous phases have received increasing attention because of their potential use in tissue engineering, cell encapsulation and for the storage and release...
Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels
Abstract: Microcapsules and microgels consisting of macromolecular networks have received increasing attention due to their biomedical and pharmaceutical applications. Protein microgels and in particular silk-based microcapsules...
Microfluidic approaches for the analysis of protein–protein interactions in solution
Abstract: Exploration and characterisation of the human proteome is a key objective enabling a heightened understanding of biological function, malfunction and pharmaceutical design. Since proteins typically exhibit their...
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.
Francesco Simone Ruggeri, Tomas Šneideris, Sean Chia, Michele Vendruscolo, Tuomas PJ Knowles
Apr 25, 2019
Atomic force microscopy for single molecule characterisation of protein aggregation.
The development of atomic force microscopy (AFM) has opened up a wide range of novel opportunities in nanoscience and new modalities of observation in complex biological systems. AFM imaging has been widely employed to resolve...
In situ Sub-Cellular Identification of Functional Amyloids in Bacteria and Archaea by Infrared Nanospectroscopy.
Daniel E Otzen, Morten S Dueholm, Zahra Najarzadeh, Tuomas PJ Knowles, Francesco Simone Ruggeri
May 06, 2021
Formation of amyloid structures is originally linked to human disease. However, amyloid materials are found extensively in the animal and bacterial world where they stabilize intra- and extra-cellular environments like biofilms...
Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films
Ayaka Kamada, Marc Rodriguez-Garcia, Francesco Simone Ruggeri, Yi Shen, Aviad Levin, Tuomas P. J. Knowles
Jun 10, 2021
Split & mix assembly of DNA libraries for ultrahigh throughput on-bead screening of functional proteins.
Laurens Lindenburg, Tuomas Huovinen, Kayleigh van de Wiel, Michael Herger, Michael R Snaith, Florian Hollfelder
Apr 21, 2020
Nanoscale click-reactive scaffolds from peptide self-assembly.
Alexander Guttenplan, Laurence J Young, Dijana Matak Vinkovic, Clemens Kaminski, Tuomas Knowles, Laura Itzhaki
May 03, 2018
Background
Due to their natural tendency to self-assemble, proteins and peptides are important components for organic nanotechnology. One particular class of peptides of recent interest is those that form amyloid fibrils, as...
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