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Motives and Correlates of Anabolic-Androgenic Steroid Use With Stimulant Polypharmacy
Individuals who use anabolic-androgenic steroids (AAS) may engage in concurrent psychoactive drug use recreationally and/or as an additional training aid. Aside from cannabis, individuals who use AAS most commonly report...
anabolic steroids polydrug psychoactive drugs stimulants /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2719 name=Health Policy /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/subjectarea/asjc/3300/3308 name=Law /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Motives and Correlates of Anabolic-Androgenic Steroid Use With Stimulant Polypharmacy
Individuals who use anabolic-androgenic steroids (AAS) may engage in concurrent psychoactive drug use recreationally and/or as an additional training aid. Aside from cannabis, individuals who use AAS most commonly report...
anabolic steroids polydrug psychoactive drugs stimulants /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2719 name=Health Policy /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/subjectarea/asjc/3300/3308 name=Law /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Comparative Analysis of SARS-CoV-2 Variants of Concern, Including Omicron, Highlights Their Common and Distinctive Amino Acid Substitution Patterns, Especially at the Spike ORF.
Marios Nikolaidis, Athanasios Papakyriakou, Katerina Chlichlia, Panayotis Markoulatos, Stephen G Oliver, Grigorios D Amoutzias
May 24, 2022
In order to gain a deeper understanding of the recently emerged and highly divergent Omicron variant of concern (VoC), a study of amino acid substitution (AAS) patterns was performed and compared with those of the other four...
Association of genetic variation with systolic and diastolic blood pressure among African Americans
Ervin R Fox, J Hunter Young, Yali Li, Albert W Dreisbach, Brendan J Keating, Solomon K Musani, Kiang Liu, Alanna C Morrison, Santhi Ganesh, Abdullah Kutlar, Vasan S Ramachandran, Josef F Polak, Richard R Fabsitz, Daniel L Dries, Deborah N Farlow, Susan Redline, Adebowale Adeyemo, Joel N Hirschorn, Yan V Sun, Sharon B Wyatt, Alan D Penman, Walter Palmas, Jerome I Rotter, Raymond R Townsend, Ayo P Doumatey, Bamidele O Tayo, Thomas H Mosley, Helen N Lyon, Sun J Kang, Charles N Rotimi, Richard S Cooper, Nora Franceschini, J David Curb, Lisa W Martin, Charles B Eaton, Sharon LR Kardia, Herman A Taylor, Mark J Caulfield, Georg B Ehret, Toby Johnson, International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Aravinda Chakravarti, Xiaofeng Zhu, Daniel Levy
Sep 06, 2019
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic...
Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh
Apr 23, 2020
Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α)...
Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy
Amanda J Cross, Kate Wooldrage, Emma C Robbins, Ines Kralj-Hans, Eilidh MacRae, Carolyn Piggott, Iain Stenson, Aaron Prendergast, Bhavita Patel, Kevin Pack, Rosemary Howe, Nicholas Swart, Julia Snowball, Stephen W Duffy, Stephen Morris, Christian von Wagner, Stephen P Halloran, Wendy S Atkin
Sep 11, 2020
OBJECTIVE: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or...
Adenoma Colonoscopy colorectal cancer stool markers SURVEILLANCE Adenoma Aged Colonic Polyps Colonoscopy Colorectal Neoplasms Cost-Benefit Analysis Early Detection of Cancer England False Negative Reactions Female Health Care Costs Humans Male Middle Aged Occult Blood Population Surveillance Predictive Value of Tests Sensitivity and Specificity
Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms.
Marc Clément, Joel Chappell, Juliette Raffort, Fabien Lareyre, Marie Vandestienne, Annabel L Taylor, Alison Finigan, James Harrison, Martin R Bennett, Patrick Bruneval, Soraya Taleb, Helle F Jørgensen, Ziad Mallat
Mar 29, 2019
Objective- Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the...
Angiotensin II Autophagy clones Endoplasmic Reticulum Inflammation Mice Smooth muscle cells Adult Aged aortic dissection Angiotensin II Animals Aorta Aortic Aneurysm Autophagy Autophagy-Related Protein 5 Cell Lineage Cell Plasticity Cells Cultured Disease Models Animal Endoribonucleases Female Humans Male Mice 129 Strain Mice Inbred C57BL Mice Knockout ApoE Middle Aged Muscle Smooth Vascular Myocytes Smooth Muscle Phenotype Protein Serine-Threonine Kinases Signal Transduction
Hepatocyte gene expression and DNA methylation as ancestry-dependent mechanisms in African Americans.
African Americans (AAs) are an admixed population with widely varying proportion of West African ancestry (WAA). Here we report the correlation of WAA to gene expression and DNA methylation in AA-derived hepatocytes, a cell type...
Multi-parametric and multi-regional histogram analysis of MRI
Chao Li, Shuo Wang, Angela Serra, Turid Torheim, Jiun-Lin Yan, Natalie R Boonzaier, Yuan Huang, Tomasz Matys, Mary A McLean, Florian Markowetz, Stephen J Price
Feb 25, 2019
OBJECTIVES: Integrating multiple imaging modalities is crucial for MRI data interpretation. The purpose of this study is to determine whether a previously proposed multi-view approach can effectively integrate the histogram...
Glioblastoma Machine Learning Magnetic Resonance Imaging Prognosis Survival Analysis Brain Brain Neoplasms Cluster Analysis Contrast Media Female Glioblastoma Humans Image Enhancement Kaplan-Meier Estimate Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Phenotype Proportional Hazards Models Reproducibility of Results Retrospective Studies
Decoding the Interdependence of Multiparametric Magnetic Resonance Imaging to Reveal Patient Subgroups Correlated with Survivals.
Chao Li, Shuo Wang, Pan Liu, Turid Torheim, Natalie R Boonzaier, Bart RJ van Dijken, Carola-Bibiane Schönlieb, Florian Markowetz, Stephen J Price
Mar 21, 2019
Glioblastoma is highly heterogeneous in microstructure and vasculature, creating various tumor microenvironments among patients, which may lead to different phenotypes. The purpose was to interrogate the interdependence of...
Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging.
Chao Li, Shuo Wang, Jiun-Lin Yan, Turid Torheim, Natalie R Boonzaier, Rohitashwa Sinha, Tomasz Matys, Florian Markowetz, Stephen J Price
Mar 21, 2019
Human genetics of leishmania infections.
Identifying genetic risk factors for parasitic infections such as the leishmaniases could provide important leads for improved therapies and vaccines. Until recently most genetic studies of human leishmaniasis were underpowered...
Optoacoustic Imaging Detects Hormone-Related Physiological Changes of Breast Parenchyma.
Oshaani Abeyakoon, Stefan Morscher, Nina Dalhaus, Steven J Ford, Iosif A Mendichovszky, Roido Manavaki, Matthew Wallis, Penelope Moyle, Ramona Woitek, Andrew Patterson, Turid Torheim, James Joseph, Isabel Quiros Gonzalez, Sarah Bohndiek, Fiona J Gilbert
Sep 05, 2018
PURPOSE: Optoacoustic imaging with ultrasound (OPUS) can assess in-vivo perfusion/oxygenation through surrogate measures of oxy, deoxy and total hemoglobin content in tissues. The primary aim of our study was to evaluate the...
Human genetics of leishmania infections
Abstract: Identifying genetic risk factors for parasitic infections such as the leishmaniases could provide important leads for improved therapies and vaccines. Until recently most genetic studies of human leishmaniasis were...
Subclonal diversification of primary breast cancer revealed by multiregion sequencing.
Lucy R Yates, Moritz Gerstung, Stian Knappskog, Christine Desmedt, Gunes Gundem, Peter Van Loo, Turid Aas, Ludmil B Alexandrov, Denis Larsimont, Helen Davies, Yilong Li, Young Seok Ju, Manasa Ramakrishna, Hans Kristian Haugland, Peer Kaare Lilleng, Serena Nik-Zainal, Stuart McLaren, Adam Butler, Sancha Martin, Dominic Glodzik, Andrew Menzies, Keiran Raine, Jonathan Hinton, David Jones, Laura J Mudie, Bing Jiang, Delphine Vincent, April Greene-Colozzi, Pierre-Yves Adnet, Aquila Fatima, Marion Maetens, Michail Ignatiadis, Michael R Stratton, Christos Sotiriou, Andrea L Richardson, Per Eystein Lønning, David C Wedge, Peter J Campbell
Nov 01, 2018
The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying biological abnormalities driving a particular patient's tumor. However, sequencing-based strategies rely heavily on representative sampling...
Hypoxia and perfusion in breast cancer
Julia C Carmona-Bozo, Roido Manavaki, Ramona Woitek, Turid Torheim, Gabrielle C Baxter, Corradina Caracò, Elena Provenzano, Martin J Graves, Tim D Fryer, Andrew J Patterson, Fiona J Gilbert
Jun 09, 2020
Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival.
Chao Li, Jiun-Lin Yan, Turid Torheim, Mary A McLean, Natalie R Boonzaier, Jingjing Zou, Yuan Huang, Jianmin Yuan, Bart RJ van Dijken, Tomasz Matys, Florian Markowetz, Stephen J Price
Feb 25, 2019
BACKGROUND AND PURPOSE: Glioblastoma exhibits profound intratumoral heterogeneity in perfusion. Particularly, low perfusion may induce treatment resistance. Thus, imaging approaches that define low perfusion compartments are...
diffusion imaging Glioblastoma Heterogeneity Perfusion Imaging radioresistance Tumor habitat imaging Adult Aged Chemoradiotherapy Cohort Studies Diffusion Magnetic Resonance Imaging Female Glioblastoma Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Invasiveness Supratentorial Neoplasms Survival Rate Temozolomide Young Adult
Altmetric Mapping of Highly-Cited Articles on Plagiarism in India
The study aims to explore the online attention received by the top twenty highly cited publications on plagiarism published between 2011 to 2020 from India by using the observation method. The bibliographical data were collected...
Published by: IGI Global Scientific Publishing
Generating evidence on the use of Image and performance enhancing drugs in the UK
Jim McVeigh, Evelyn Hearne, Ian Boardley, Geoff Bates, Vivian Hope, Rob Ralphs, Marie-Claire Van Hout
Oct 17, 2021
Background
The use of anabolic androgenic steroids (AAS) and associated image and performance enhancing drugs (IPEDs) is now a global phenomenon. There is a need to develop evidence to support the development of...
The use of anabolic androgenic steroids (AAS) and associated image and performance enhancing drugs (IPEDs) is now a global phenomenon. There is a need to develop evidence to support the development of...
Generating evidence on the use of Image and performance enhancing drugs in the UK
Jim McVeigh, Evelyn Hearne, Ian Boardley, Geoff Bates, Vivian Hope, Rob Ralphs, Marie-Claire Van Hout
Oct 17, 2021
Background
The use of anabolic androgenic steroids (AAS) and associated image and performance enhancing drugs (IPEDs) is now a global phenomenon. There is a need to develop evidence to support the development of...
The use of anabolic androgenic steroids (AAS) and associated image and performance enhancing drugs (IPEDs) is now a global phenomenon. There is a need to develop evidence to support the development of...
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A Gallagher, Ramona Woitek, Mary A McLean, Andrew B Gill, Raquel Manzano Garcia, Elena Provenzano, Frank Riemer, Joshua Kaggie, Anita Chhabra, Stephan Ursprung, James T Grist, Charlie J Daniels, Fulvio Zaccagna, Marie-Christine Laurent, Matthew Locke, Sarah Hilborne, Amy Frary, Turid Torheim, Chris Boursnell, Amy Schiller, Ilse Patterson, Rhys Slough, Bruno Carmo, Justine Kane, Heather Biggs, Emma Harrison, Surrin S Deen, Andrew Patterson, Titus Lanz, Zoya Kingsbury, Mark Ross, Bristi Basu, Richard Baird, David J Lomas, Evis Sala, James Wason, Oscar M Rueda, Suet-Feung Chin, Ian B Wilkinson, Martin J Graves, Jean E Abraham, Fiona J Gilbert, Carlos Caldas, Kevin M Brindle
Feb 06, 2020
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A Gallagher, Ramona Woitek, Mary A McLean, Andrew B Gill, Raquel Manzano Garcia, Elena Provenzano, Frank Riemer, Joshua Kaggie, Anita Chhabra, Stephan Ursprung, James T Grist, Charlie J Daniels, Fulvio Zaccagna, Marie-Christine Laurent, Matthew Locke, Sarah Hilborne, Amy Frary, Turid Torheim, Chris Boursnell, Amy Schiller, Ilse Patterson, Rhys Slough, Bruno Carmo, Justine Kane, Heather Biggs, Emma Harrison, Surrin S Deen, Andrew Patterson, Titus Lanz, Zoya Kingsbury, Mark Ross, Bristi Basu, Richard Baird, David J Lomas, Evis Sala, James Wason, Oscar M Rueda, Suet-Feung Chin, Ian B Wilkinson, Martin J Graves, Jean E Abraham, Fiona J Gilbert, Carlos Caldas, Kevin M Brindle
Feb 22, 2020
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between injected [1-13C]pyruvate...
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