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Tweeting about twenty
BACKGROUND: Twenty miles per hour (20mph) speed limits (equivalent to roughly 30kmh) have become part of public health policies to reduce urban road collisions and casualties, especially in Western countries. Public opinion...
Tweeting about twenty
BACKGROUND: Twenty miles per hour (20mph) speed limits (equivalent to roughly 30kmh) have become part of public health policies to reduce urban road collisions and casualties, especially in Western countries. Public opinion...
Kanamycin-Mediated Conformational Dynamics of Escherichia coli Outer Membrane Protein TolC.
Biraja S Pattanayak, Budheswar Dehury, Mamali Priyadarshinee, Suman Jha, Tushar K Beuria, Dhananjay Soren, Bairagi C Mallick
Apr 29, 2021
TolC is a member of the outer membrane efflux proteins (OEPs) family and acts as an exit duct to export proteins, antibiotics, and substrate molecules across the Escherichia coli cell membrane. Export of these molecules is...
Evolutionary and functional insights into Leishmania META1
BACKGROUND: Leishmania META1 has for long been a candidate molecule for involvement in virulence: META1 transcript and protein are up-regulated in metacyclic Leishmania. Yet, how META1 contributes to virulence remains unclear....
Amino Acid Sequence Bacterial Proteins Base Composition DNA Protozoan evolution Molecular Gene Transfer Horizontal Leishmania Models Molecular Molecular Sequence Data Mutagenesis Site-Directed Phylogeny Protein Structure Tertiary Protozoan Proteins selection Genetic Sequence Alignment Sequence Analysis DNA Virulence
Emotion Detection via Voice and Speech Recognition
Emotion detection from voice signals is needed for human-computer interaction (HCI), which is a difficult challenge. In the literature on speech emotion recognition, various well known speech analysis and classification methods...
Published by: IGI Global Scientific Publishing
Critical care management of traumatic brain injury.
Traumatic brain injury (TBI) is a growing global problem, which is responsible for a substantial burden of disability and death, and which generates substantial healthcare costs. High-quality intensive care can save lives and...
ICU Structure and Outcomes Following Traumatic Brain Injury.
We read with interest the paper from McCredie et al in Critical Care Medicine. The authors retrospectively analysed data from 9773 patients from 134 intensive care units (ICUs), obtained between 2011 and 2013, extracted from a...
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
Elisabete M Nascimento, Claire L Cox, Stewart MacArthur, Shobbir Hussain, Matthew Trotter, Sandra Blanco, Menon Suraj, Jennifer Nichols, Bernd Kübler, Salvador Aznar Benitah, Brian Hendrich, Duncan T Odom, Michaela Frye
Jan 31, 2020
How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation...
Animals Epidermal Cells epidermis Feedback Physiological Female Homeostasis Keratinocytes Kruppel-Like Factor 4 Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Primary Cell Culture Proto-Oncogene Proteins c-myc Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex Transcription Genetic
Robustness and Independent Evidence
Robustness arguments hold that hypotheses are more likely to be true when they are confirmed by diverse kinds of evidence. Robustness arguments require the confirming evidence to be independent. We identify two kinds of...
Withdrawal of treatment after devastating brain injury
Every year in England, cardiopulmonary resuscitation (CPR) is attempted on about 30,000 people suffering an out of hospital cardiac arrest (OHCA) [1]. Return of spontaneous circulation (ROSC) is achieved in approximately 25%...
Moving to human trials for argon neuroprotection in neurological injury
Despite the global burden of brain injury, neuroprotective agents remain elusive. There are no clinically effective therapies which reduce mortality or improve long-term cognitive outcome. Ventilation could be an easily...
Electronic clinical decision support tool for assessing stomach symptoms in primary care (ECASS)
Greg Rubin, Fiona M Walter, Jon Emery, Willie Hamilton, Zoe Hoare, Jenny Howse, Catherine Nixon, Tushar Srivastava, Chloe Thomas, Obioha C Ukoumunne, Juliet A Usher-Smith, Sophie Whyte, Richard D Neal
Mar 22, 2021
Objective: To determine the feasibility of a definitive trial in primary care of electronic clinical decision support (eCDS) for possible oesophago-gastric (O-G) cancer. Design and setting: Feasibility study in 42 general...
Default Mode Contributions to Automated Information Processing
Intrinsic brain dynamics in the Default Mode Network predict involuntary fluctuations of visual awareness
Abstract Brain activity is intrinsically organised into spatiotemporal patterns, but it is still not clear whether these intrinsic patterns are functional or epiphenomenal. Using a simultaneous...
Reactivity of Polycyclic Aromatic Hydrocarbon Soot Precursors
The thermodynamics and kinetics of cross-linking reactions between PAHs of various reactive edge types that are observed in soot precursors are explored using density functional theory. The forward rate constants confirm that...
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