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Hyperinsulinaemic-hypoglycaemic glucose clamps in human research
Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes
Clementine EM Verhulst, Therese W Fabricius, Steven Teerenstra, Peter L Kristensen, Cees J Tack, Rory J McCrimmon, Simon Heller, Mark L Evans, Stephanie A Amiel, Ulrik Pedersen-Bjergaard, Bastiaan E de Galan, Hypo-RESOLVE consortium
Sep 15, 2022
AIM/HYPOTHESIS: The physiological counterregulatory response to hypoglycaemia is reported to be organised hierarchically, with hormone responses usually preceding symptomatic awareness and autonomic responses preceding...
Counterregulatory hormones Diabetes Glycaemic thresholds human Hyperinsulinaemic–hypoglycaemic stepped clamp hypoglycaemia Symptomatic responses Systematic review Blood Glucose Diabetes mellitus Type 1 Epinephrine Female growth hormone Humans Hydrocortisone Hypoglycemia Hypoglycemic Agents Insulin Male Norepinephrine
Hyperinsulinaemic–hypoglycaemic glucose clamps in human research
Therese W. Fabricius, Clementine E. M. Verhulst, Peter L. Kristensen, Cees J. Tack, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Stephanie A. Amiel, Thomas R. Pieber, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard
Mar 08, 2021
Abstract: Aims/hypothesis: The hyperinsulinaemic–hypoglycaemic glucose clamp technique has been developed and applied to assess effects of and responses to hypoglycaemia under standardised conditions. However, the degree to...
Psychometric properties of an innovative smartphone application to investigate the daily impact of hypoglycemia in people with type 1 or type 2 diabetes
Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill Carlton, Julia K Mader, Petra Martina Baumann, Mikel Gomes, Gilberte Martine-Edith, Daniel J Pollard, Dajana Rath, Simon Heller, Ulrik Pedersen-Bjergaard, Rory J McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas Forkmann, Stephanie A Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer
Apr 17, 2023
Introduction
The aim of this study was to determine the acceptability and psychometric properties of the Hypo-METRICS (Hypoglycemia MEasurement, ThResholds and ImpaCtS) application (app): a novel tool designed to assess...
Humans Diabetes mellitus Type 1 Diabetes mellitus Type 2 Hypoglycemia Insulin Reproducibility of Results Psychometrics Adult Aged Middle Aged Benchmarking Mobile Applications Smartphone Surveys and Questionnaires
Published by: PLOS ONE
Hypo‐METRICS: Hypoglycaemia—MEasurement, ThResholds and ImpaCtS—A multi‐country clinical study to define the optimal threshold and duration of sensor‐detected hypoglycaemia that impact the experience of hypoglycaemia, quality of life and health economic outcomes
Patrick Divilly, Natalie Zaremba, Zeinab Mahmoudi, Uffe Søholm, Daniel J Pollard, Melanie Broadley, Evertine J Abbink, Bastiaan de Galan, Ulrik Pedersen‐Bjergaard, Eric Renard, Mark Evans, Jane Speight, Alan Brennan, Rory J McCrimmon, Matthias Müllenborn, Simon Heller, Alexander Seibold, Julia K Mader, Stephanie A Amiel, Frans Pouwer, Pratik Choudhary
Jun 29, 2022
Psychometric properties of an innovative smartphone application to investigate the daily impact of hypoglycemia in people with type 1 or type 2 diabetes
Introduction
The aim of this study was to determine the acceptability and psychometric properties of the Hypo-METRICS (Hypoglycemia MEasurement, ThResholds and ImpaCtS)...
Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill Carlton, Julia K Mader, Petra Martina Baumann, Mikel Gomes, Gilberte Martine-Edith, Daniel J Pollard, Dajana Rath, Simon Heller, Ulrik Pedersen-Bjergaard, Rory J McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas Forkmann, Stephanie A Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer
Mar 17, 2023
Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.
Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction...
Open Educational Resources in Higher Education
Open educational resources (OER) are openly licensed educational materials that can be used in different educational settings to help make education available to all. However, proper deployment of OER still faces many barriers...
Published by: IGI Global Scientific Publishing
Theory of visual attention (TVA) applied to rats performing the 5-choice serial reaction time task
Mona El-Sayed Hervig, Chiara Toschi, Anders Petersen, Signe Vangkilde, Ulrik Gether, Trevor W Robbins
Jan 05, 2023
RATIONALE: Attention is compromised in many psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). While dopamine and noradrenaline systems have been implicated in ADHD, their exact role in attentional...
ADHD Amphetamine Atipamezole atomoxetine Attention methylphenidate Phenylephrine TVA Visual processing Rats Humans Animals Reaction Time Atomoxetine Hydrochloride Dopamine methylphenidate Amphetamine Attention Deficit Disorder with Hyperactivity Norepinephrine Phenylephrine Central Nervous System Stimulants
Cancer Core Europe
Fabien Calvo, Giovanni Apolone, Michael Baumann, Carlos Caldas, Julio E Celis, Franceso de Lorenzo, Ingemar Ernberg, Ulrik Ringborg, John Rowell, Josep Tabernero, Emile Voest, Alexander Eggermont
Nov 21, 2018
Translational cancer research covers the whole cancer research continuum from basic to preclinical to early clinical, late clinical and outcomes research. Basic-preclinical research is the "engine" for early clinical research...
Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task
Chiara Toschi, Mona El-Sayed Hervig, Parisa Moazen, Maximilian G Parker, Jeffrey W Dalley, Ulrik Gether, Trevor W Robbins
Aug 19, 2021
BACKGROUND: Work in humans has shown that impulsivity can be advantageous in certain settings. However, evidence for so-called functional impulsivity is lacking in experimental animals. AIMS: This study investigated the contexts...
A capped optimal stopping problem for the maximum process
This paper concerns an optimal stopping problem driven by the running maximum of a spectrally negative Lévy process X. More precisely, we are interested in capped versions of the American lookback optimal stopping problem...
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Louise Thisted, Mette V. Østergaard, Annemarie A. Pedersen, Philip J. Pedersen, Ross T. Lindsay, Andrew J. Murray, Lisbeth N. Fink, Tanja X. Pedersen, Thomas Secher, Thea T. Johansen, Sebastian T. Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B. Thomsen, Nora E. Zois
Oct 01, 2021
Abstract: Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models...
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Louise Thisted, Mette V. Østergaard, Annemarie A. Pedersen, Philip J. Pedersen, Ross T. Lindsay, Andrew J. Murray, Lisbeth N. Fink, Tanja X. Pedersen, Thomas Secher, Thea T. Johansen, Sebastian T. Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B. Thomsen, Nora E. Zois
Sep 30, 2020
Abstract: Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models...
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy.
Louise Thisted, Mette V Østergaard, Annemarie A Pedersen, Philip J Pedersen, Ross T Lindsay, Andrew J Murray, Lisbeth N Fink, Tanja X Pedersen, Thomas Secher, Thea T Johansen, Sebastian T Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B Thomsen, Nora E Zois
Dec 04, 2020
Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models...
Human-Mouse Chimerism Validates Human Stem Cell Pluripotency.
A capped optimal stopping problem for the maximum process
This paper concerns an optimal stopping problem driven by the running maximum of a spectrally negative Lévy process X. More precisely, we are interested in capped versions of the American lookback optimal stopping problem...
3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices.
Janko Kajtez, Sebastian Buchmann, Shashank Vasudevan, Marcella Birtele, Stefano Rocchetti, Christian Jonathan Pless, Arto Heiskanen, Roger A Barker, Alberto Martínez-Serrano, Malin Parmar, Johan Ulrik Lind, Jenny Emnéus
Jul 16, 2020
Compartmentalized microfluidic platforms are an invaluable tool in neuroscience research. However, harnessing the full potential of this technology remains hindered by the lack of a simple fabrication approach for the creation...
Cancer Core Europe
Alexander MM Eggermont, Giovanni Apolone, Michael Baumann, Carlos Caldas, Julio E Celis, Francesco de Lorenzo, Ingemar Ernberg, Ulrik Ringborg, John Rowell, Josep Tabernero, Emile Voest, Fabien Calvo
Apr 09, 2019
Cancer Core Europe is a European legal alliance consisting of seven leading cancer centres - most of them Comprehensive Cancer Centres (CCCs) - with a single portal system to engage in various research projects with partners....
Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task.
Chiara Toschi, Mona El-Sayed Hervig, Thiago Burghi, Torben Sell, Matthew Dominic Lycas, Parisa Moazen, Li Huang, Ulrik Gether, Trevor W Robbins, Jeffrey W Dalley
Jun 15, 2022
Negative urgency describes the tendency for rash and impulsive behaviour during negative emotional states and has been linked to a number of psychiatric disorders. However, there has been limited research on negative urgency as...
Impulsivity traits and addiction-related behaviors in youth.
Kristine Rømer Thomsen, Mette Buhl Callesen, Morten Hesse, Timo Lehmann Kvamme, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Valerie Voon
Jun 21, 2018
A theoretical analysis of taxonomic binning accuracy.
Many metagenomic and environmental DNA studies require the taxonomic assignment of individual reads or sequences by aligning reads to a reference database, known as taxonomic binning. When a read aligns to more than one...
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
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