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Results: 35
Alcohol taxation and premature mortality in Europe
Witold A Zatoński, Urszula Sulkowska, Mateusz Z Zatoński, Aleksandra A Herbeć, Magdalena M Muszyńska
Mar 28, 2015
Alcohol taxation and premature mortality in Europe
Witold A Zatoński, Urszula Sulkowska, Mateusz Z Zatoński, Aleksandra A Herbeć, Magdalena M Muszyńska
Mar 28, 2015
SARS-CoV-2 Papain-Like Protease Potential Inhibitors-In Silico Quantitative Assessment.
Adam Stasiulewicz, Alicja W Maksymiuk, Mai Lan Nguyen, Barbara Bełza, Joanna I Sulkowska
Apr 13, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes the papain-like protease (PLpro). The protein not only plays an essential role in viral replication but also cleaves ubiquitin and ubiquitin-like...
covid-19 PLpro SARS-CoV-2 UCH-L1 coronavirus docking papain-like protease pharmacophore Virtual screening Animals Antiviral Agents Computer Simulation Coronavirus Papain-Like Proteases Crystallography X-Ray Databases Chemical Databases Protein Drug Evaluation Preclinical Humans Inhibitory Concentration 50 Lethal Dose 50 Ligands Mutagenicity Tests Protease Inhibitors Quantitative Structure-Activity Relationship Rats SARS-CoV-2 Ubiquitin Thiolesterase
Digit ratio (2D
BACKGROUND: Digit ratio (2D:4D) is used by researchers as an indicator of prenatal sex hormone exposure. Two previous studies have examined associations between 2D:4D and circulating sex steroid concentrations across the...
Triboelectric Yarns with Electrospun Functional Polymer Coatings for Highly Durable and Washable Smart Textile Applications.
Tommaso Busolo, Piotr K Szewczyk, Malavika Nair, Urszula Stachewicz, Sohini Kar-Narayan
Mar 19, 2021
Triboelectric generators are excellent candidates for smart textiles applications due to their ability to convert mechanical energy into electrical energy. Such devices can be manufactured into yarns by coating a conductive core...
Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding.
Agata P Perlinska, Adam Stasiulewicz, Mai Lan Nguyen, Karolina Swiderska, Mikolaj Zmudzinski, Alicja W Maksymiuk, Marcin Drag, Joanna I Sulkowska
Dec 08, 2022
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs...
Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites.
Valeria Vetri, Federica Piccirilli, Johannes Krausser, Gianpiero Buscarino, Urszula Łapińska, Bente Vestergaard, Alessio Zaccone, Vito Foderà
May 18, 2018
Protein self-assembly into amyloid fibrils or highly hierarchical superstructures is closely linked to neurodegenerative pathologies as Alzheimer's and Parkinson's diseases. Moreover, protein assemblies also emerged as building...
Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding.
Agata P Perlinska, Adam Stasiulewicz, Mai Lan Nguyen, Karolina Swiderska, Mikolaj Zmudzinski, Alicja W Maksymiuk, Marcin Drag, Joanna I Sulkowska
Dec 22, 2022
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs...
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, Maria Sladowska, Michal Turek, Barbara Uszczynska-Ratajczak, Rishika Kundra, Tomasz Goral, Michele Perni, Christopher M Dobson, Michele Vendruscolo, Agnieszka Chacinska
Sep 22, 2021
Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease.
Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans
Urszula Cytlak, Anastasia Resteu, Sarah Pagan, Kile Green, Paul Milne, Sheetal Maisuria, David McDonald, Gillian Hulme, Andrew Filby, Benjamin Carpenter, Rachel Queen, Sophie Hambleton, Rosie Hague, Hana Lango Allen, James ED Thaventhiran, Gina Doody, Matthew Collin, Venetia Bigley
Aug 05, 2020
The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the...
CyTOF IRF8 dendritic cell Hematopoiesis Immunity primary immunodeficiency single-cell RNA sequencing Transcription factor Animals Antigens CD1 Antigens CD34 Cell Line Cell Lineage Dendritic Cells Glycoproteins Hematopoiesis Hematopoietic Stem Cells Humans Interferon Regulatory Factors Interleukin-3 Receptor alpha Subunit Lipopolysaccharide Receptors Mice Receptors Immunologic
Enhanced Piezoelectricity of Electrospun Polyvinylidene Fluoride Fibers for Energy Harvesting.
Piotr K Szewczyk, Arkadiusz Gradys, Sung Kyun Kim, Luana Persano, Mateusz Marzec, Aleksandr Kryshtal, Tommaso Busolo, Alessandra Toncelli, Dario Pisignano, Andrzej Bernasik, Sohini Kar-Narayan, Paweł Sajkiewicz, Urszula Stachewicz
Mar 24, 2021
Piezoelectric polymers are promising energy materials for wearable and implantable applications for replacing bulky batteries in small and flexible electronics. Therefore, many research studies are focused on understanding the...
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.
Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, Maria Sladowska, Michal Turek, Barbara Uszczynska-Ratajczak, Rishika Kundra, Tomasz Goral, Michele Perni, Christopher M Dobson, Michele Vendruscolo, Agnieszka Chacinska
Oct 18, 2021
Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to understand whether failures in the...
C. elegans S. cerevisiae AGGREGATION Biochemistry chaperones chemical biology Homeostasis metastable proteins Mitochondria neurodegeneration Alzheimer Disease Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cytosol Databases Genetic HEAT-SHOCK PROTEINS Humans Mitochondria Mitochondrial Proteins Molecular Chaperones Protein Aggregates Protein Transport Proteostasis Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer.
Chrysiis Michaloglou, Claire Crafter, Rasmus Siersbaek, Oona Delpuech, Jon O Curwen, Larissa S Carnevalli, Anna D Staniszewska, Urszula M Polanska, Azadeh Cheraghchi-Bashi, Mandy Lawson, Igor Chernukhin, Robert McEwen, Jason S Carroll, Sabina C Cosulich
Sep 04, 2018
Animals Antineoplastic Combined Chemotherapy Protocols Benzamides Breast Neoplasms Cell Line Tumor Cell Proliferation Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 E2F Transcription Factors Female Humans MCF-7 Cells Mice SCID Morpholines Piperazines Pyridines Pyrimidines Receptors Estrogen TOR Serine-Threonine Kinases Xenograft Model Antitumor Assays
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.
Kadi L Saar, Yingbo Zhang, Thomas Müller, Challa P Kumar, Sean Devenish, Andrew Lynn, Urszula Łapińska, Xiaoting Yang, Sara Linse, Tuomas PJ Knowles
Apr 16, 2018
The ability to apply highly controlled electric fields within microfluidic devices is valuable as a basis for preparative and analytical processes. A challenge encountered in the context of such approaches in conductive media...
Surface Potential Driven Water Harvesting from Fog.
Daniel P Ura, Joanna Knapczyk-Korczak, Piotr K Szewczyk, Ewa A Sroczyk, Tommaso Busolo, Mateusz M Marzec, Andrzej Bernasik, Sohini Kar-Narayan, Urszula Stachewicz
Apr 30, 2021
Access to clean water is a global challenge, and fog collectors are a promising solution. Polycarbonate (PC) fibers have been used in fog collectors but with limited efficiency. In this study, we show that controlling voltage...
Engineering Chirally Blind Protein Pseudocapsids into Antibacterial Persisters.
Ibolya E Kepiro, Irene Marzuoli, Katharine Hammond, Xiaoliang Ba, Helen Lewis, Michael Shaw, Smita B Gunnoo, Emiliana De Santis, Urszula Łapińska, Stefano Pagliara, Mark A Holmes, Christian D Lorenz, Bart W Hoogenboom, Franca Fraternali, Maxim G Ryadnov
Jan 23, 2020
Antimicrobial resistance stimulates the search for antimicrobial forms that may be less subject to acquired resistance. Here we report a conceptual design of protein pseudocapsids exhibiting a broad spectrum of antimicrobial...
Mechanisms Underlying Disorders of Consciousness
Andrea I. Luppi, Joshua Cain, Lennart R. B. Spindler, Urszula J. Górska, Daniel Toker, Andrew E. Hudson, Emery N. Brown, Michael N. Diringer, Robert D. Stevens, Marcello Massimini, Martin M. Monti, Emmanuel A. Stamatakis, Melanie Boly
Jul 28, 2021
Mechanisms Underlying Disorders of Consciousness
Andrea Luppi, Joshua Cain, Lennart Spindler, Urszula J Górska, Daniel Toker, Andrew E Hudson, Emery N Brown, Michael N Diringer, Robert D Stevens, Marcello Massimini, Martin M Monti, Emmanuel Stamatakis, Melanie Boly, Curing Coma Campaign and Its Contributing Collaborators
Jan 28, 2022
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E Koromilas
Aug 31, 2021
The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most...
adenine Adenocarcinoma Animals Carcinogenesis Cell Line Tumor Dual Specificity Phosphatase 6 Eukaryotic Initiation Factor-2 Female Humans Indoles Kaplan-Meier Estimate Lung Neoplasms Male Mice Nude Mitogen-Activated Protein Kinases Phosphorylation Proto-Oncogene Proteins p21(ras) Stress Physiological Xenograft Model Antitumor Assays
Mechanisms Underlying Disorders of Consciousness
Andrea I. Luppi, Joshua Cain, Lennart R. B. Spindler, Urszula J. Górska, Daniel Toker, Andrew E. Hudson, Emery N. Brown, Michael N. Diringer, Robert D. Stevens, Marcello Massimini, Martin M. Monti, Emmanuel A. Stamatakis, Melanie Boly
Oct 01, 2021
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.
Tom Scheidt, Urszula Łapińska, Janet R Kumita, Daniel R Whiten, David Klenerman, Mark R Wilson, Samuel IA Cohen, Sara Linse, Michele Vendruscolo, Christopher M Dobson, Tuomas PJ Knowles, Paolo Arosio
May 28, 2019
The aggregates of the Aβ peptide associated with Alzheimer's disease are able to both grow in size as well as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with...
Mechanisms Underlying Disorders of Consciousness
Andrea Luppi, Joshua Cain, Lennart Spindler, Urszula J Górska, Daniel Toker, Andrew E Hudson, Emery N Brown, Michael N Diringer, Robert D Stevens, Marcello Massimini, Martin M Monti, Emmanuel Stamatakis, Melanie Boly, Curing Coma Campaign and Its Contributing Collaborators
Jul 05, 2021
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Jul 30, 2021
Abstract: The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development...
Mechanisms Underlying Disorders of Consciousness
Andrea I Luppi, Joshua Cain, Lennart RB Spindler, Urszula J Górska, Daniel Toker, Andrew E Hudson, Emery N Brown, Michael N Diringer, Robert D Stevens, Marcello Massimini, Martin M Monti, Emmanuel A Stamatakis, Melanie Boly, Curing Coma Campaign and Its Contributing Collaborators
Apr 01, 2022
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