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Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Maik Pietzner, Beatrice Engelmann, Tim Kacprowski, Janine Golchert, Anna-Luise Dirk, Elke Hammer, K Alexander Iwen, Matthias Nauck, Henri Wallaschofski, Dagmar Führer, Thomas F Münte, Nele Friedrich, Uwe Völker, Georg Homuth, Georg Brabant
Nov 16, 2020
BACKGROUND: Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize...
A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans.
Maik Pietzner, Josef Köhrle, Ina Lehmphul, Kathrin Budde, Gabi Kastenmüller, Georg Brabant, Henry Völzke, Anna Artati, Jerzy Adamski, Uwe Völker, Matthias Nauck, Nele Friedrich, Georg Homuth
Jan 10, 2020
Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to...
3 5-diiodothyronine caffeine metabolism Metabolomics Thyroid thyrotoxicosis Adult caffeine Coffee DNA Fingerprinting Diiodothyronines Female Healthy Volunteers Humans Magnetic Resonance Spectroscopy Male Mass Spectrometry Metabolomics Middle Aged Reference Values Thyroid Function Tests Thyroid Hormones Thyrotoxicosis Thyrotropin Thyroxine
Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy
Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdränk, Michael P. Murphy, Thomas Krieg, Marcus Dörr, Uwe Völker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus, Benjamin Meder
Feb 20, 2021
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and...
Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels.
Abhishek Nag, Yuko Kurushima, Ruth CE Bowyer, Philippa M Wells, Stefan Weiss, Maik Pietzner, Thomas Kocher, Johannes Raffler, Uwe Völker, Massimo Mangino, Timothy D Spector, Michael V Milburn, Gabi Kastenmüller, Robert P Mohney, Karsten Suhre, Cristina Menni, Claire J Steves
Jan 12, 2021
Saliva, as a biofluid, is inexpensive and non-invasive to obtain, and provides a vital tool to investigate oral health and its interaction with systemic health conditions. There is growing interest in salivary biomarkers for...
Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy.
Jan Haas, Karen S Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdränk, Michael P Murphy, Thomas Krieg, Marcus Dörr, Uwe Völker, Jens Fielitz, Norbert Frey, Stephan B Felix, Andreas Keller, Hugo A Katus, Benjamin Meder
Feb 25, 2021
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and...
Inside the Anthropocene
Uwe Voigt
Jan 07, 2019
This paper deals with the question, what does it mean to be inside the Anthropocene? In order to answer this question in the first place one hasto have a notion of what the Anthropocene is. There is a seemingly simple factual...
Published by: Memorial University of Newfoundland
Inside the Anthropocene
Uwe Voigt
Jan 07, 2019
This paper deals with the question, what does it mean to be inside the Anthropocene? In order to answer this question in the first place one hasto have a notion of what the Anthropocene is. There is a seemingly simple factual...
Published by: Memorial University of Newfoundland
Hidden figures
Uwe Peters
Mar 04, 2021
Abstract: Demographic diversity might often be present in a group without group members noticing it. What are the epistemic effects if they do? Several philosophers and social scientists have recently argued that when...
Hidden figures
Uwe Peters
Mar 31, 2021
Demographic diversity might often be present in a group without group members noticing it. What are the epistemic effects if they do? Several philosophers and social scientists have recently argued that when individuals detect...
Objectivity, perceptual constancy, and teleology in young children
Uwe Peters
Nov 16, 2022
Can young children such as 3‐year‐olds represent the world objectively? Some prominent developmental psychologists—such as Perner and Tomasello—assume so. I argue that this view is susceptible to a prima facie powerful...
Internet Voting and Turnout
Internet voting (i-voting) is often discussed as a potential remedy against declining turnout rates. This paper presents new evidence on the causal effect of i-voting on turnout, drawing on trials conducted in two Swiss cantons...
The ‘dark side’ of personal values
Personal values are considered as guiding principles in one's life. Much of previous research on values hasconsequently focused on its relations with variables that are considered positive, including subjective well-being...
Internet Voting and Turnout
Internet voting (i-voting) is often discussed as a potential remedy against declining turnout rates. This paper presents new evidence on the causal effect of i-voting on turnout, drawing on trials conducted in two Swiss cantons...
The source attribution effect:
We tested whether mere source attribution is sufficient to cause polarization between groups, even on consensual non-divisive positions. Across four studies (N = 2,182), using samples from Germany, the UK, and the USA, agreement...
The ‘dark side’ of personal values
Personal values are considered as guiding principles in one's life. Much of previous research on values hasconsequently focused on its relations with variables that are considered positive, including subjective well-being...
Generalization Bias in Science.
Many scientists routinely generalize from study samples to larger populations. It is commonly assumed that this cognitive process of scientific induction is a voluntary inference in which researchers assess the generalizability...
The source attribution effect:
We tested whether mere source attribution is sufficient to cause polarization between groups, even on consensual non-divisive positions. Across four studies (N = 2,182), using samples from Germany, the UK, and the USA, agreement...
Tree rings reveal signs of Europe's sustainable forest management long before the first historical evidence.
Bernhard Muigg, Georgios Skiadaresis, Willy Tegel, Franz Herzig, Paul J Krusic, Uwe E Schmidt, Ulf Büntgen
Feb 22, 2021
To satisfy the increasing demand for wood in central Europe during medieval times, a new system of forest management was developed, one far superior to simple coppicing. The adoption of a sophisticated, Coppice-with-Standards...
bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring.
Vítor Trovisco, Katsiaryna Belaya, Dmitry Nashchekin, Uwe Irion, George Sirinakis, Richard Butler, Jack J Lee, Elizabeth R Gavis, Daniel St Johnston
Jun 11, 2018
bicoid mRNA localises to the Drosophila oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at stage 9 reveals that bicoid mRNA particles undergo...
Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish
Laura Cal, Paula Suarez-Bregua, Ingo Braasch, Uwe Irion, Robert Kelsh, Jose Miguel Cerdá-Reverter, Josep Rotllant
Nov 01, 2019
The melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat coloration in amniotes. Additionally, in mammals MC1R is the main...
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