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The Privileged Life of a Theoretical Observer.
Douglas Gough
Aug 17, 2022
This is a summary of my scientific career, biased by my personal view of events and unashamedly concentrating on those aspects of some of the scientific developments to which I have contributed. A selective unbiased alternative...
The Privileged Life of a Theoretical Observer
Abstract This is a summary of my scientific career, biased by my personal view of events and unashamedly concentrating on those aspects of some of the scientific developments to which I have...
Douglas Gough
Jul 26, 2022
Computational Analysis of Vertebral Body for Compression Fracture Using Texture and Shape Features
The primary goal in this paper is to automate radiological measurements of Vertebral Body (VB) in Magnetic Resonance Imaging (MRI) spinal scans. It starts by preprocessing the images, then detect and localize the VB regions...
Published by: IGI Global Scientific Publishing
Material property calibration is more important than element size and number of different materials on the finite element modelling of vertebral bodies
Finite element (FE) modelling of a vertebral body (VB) is considered challenging due to the many parameters involved such as element size and type, and material properties. Previous studies have reported how these parameters...
Material property calibration is more important than element size and number of different materials on the finite element modelling of vertebral bodies
Finite element (FE) modelling of a vertebral body (VB) is considered challenging due to the many parameters involved such as element size and type, and material properties. Previous studies have reported how these parameters...
Longitudinal associations between prepubertal childhood total energy and macronutrient intakes and subsequent puberty timing in UK boys and girls.
Tuck Seng Cheng, Stephen J Sharp, Soren Brage, Pauline M Emmett, Nita Forouhi, Kenneth Ong
Jul 12, 2021
PURPOSE: Early puberty is associated with adverse health outcomes. To identify potential modifiable factors for puberty timing, we examined the associations of prepubertal childhood macronutrient intakes with puberty timing in...
The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family.
Fernanda CR de Paiva, Karen Chan, Markiyan Samborskyy, Ariel M Silber, Peter F Leadlay, Marcio VB Dias
Dec 07, 2020
Adenylate-forming enzymes (AFEs) are a mechanistic superfamily of proteins that are involved in many cellular roles. In the biosynthesis of benzoxazole antibiotics, an AFE has been reported to play a key role in the condensation...
Offsetting the Destruction of Marine Fish Habitat During Coastal Development Projects in Canada
Under the Fisheries Act of Canada (2012), proponents of development projects are responsible for offsetting the destruction of freshwater and marine habitat if “serious harm” is expected to occur to fish supporting a commercial...
ML-SIM
Structured illumination microscopy (SIM) has become an important technique for
optical super-resolution imaging because it allows a doubling of image resolution at speeds
compatible with live-cell imaging. However, the...
Calcium imaging analysis - how far have we come?
Techniques for calcium imaging were first demonstrated in the mid-1970s, whilst tools to analyse these markers of cellular activity are still being developed and improved today. For image analysis, custom tools were developed...
classification Neural Networks Quantification denoising calcium imaging Machine Learning motion correction
Published by: F1000Research
Offsetting the Destruction of Marine Fish Habitat During Coastal Development Projects in Canada
Under the Fisheries Act of Canada (2012), proponents of development projects are responsible for offsetting the destruction of freshwater and marine habitat if “serious harm” is expected to occur to fish supporting a commercial...
Calcium imaging analysis - how far have we come?
Techniques for calcium imaging were first demonstrated in the mid-1970s, whilst tools to analyse these markers of cellular activity are still being developed and improved today. For image analysis, custom tools were developed...
The Grizzly, February 15, 2024
Marie Sykes, Sidney Belleroche, Nicolas Ungurean, Renie Christensen, Mairead McDermott, Dominic Minicozzi, Adam Denn
Jan 01, 0001
Freedom, Transformation and Pathways: Spring Exhibits at the Berman Ursinus Faculty Discusses Generative A.I. An Artist's Craft: The Making of Running Away Everybody Dies Opinions: What Was Your Favorite Memory Studying...
Ursinus College Collegeville Pennsylvania newspaper Berman Art Museum Kukulia Velarde Adriane Colburn Sahar Tarighi Artificial Intelligence Sam Love theater morality play study abroad Basketball cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Broadband criticality of human brain network synchronization.
Self-organized criticality is an attractive model for human brain dynamics, but there has been little direct evidence for its existence in large-scale systems measured by neuroimaging. In general, critical systems are associated...
Single-site glycine-specific labeling of proteins.
Landa Purushottam, Srinivasa Rao Adusumalli, Usha Singh, VB Unnikrishnan, Dattatraya Gautam Rawale, Mansi Gujrati, Ram Kumar Mishra, Vishal Rai
Jan 25, 2021
Labeling of native proteins invites interest from diverse segments of science. However, there remains the significant unmet challenge in precise labeling at a single site of a protein. Here, we report the site-specific labeling...
Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
Marcio VB Dias, Fanglu Huang, Dimitri Y Chirgadze, Manuela Tosin, Dieter Spiteller, Emily FV Dry, Peter F Leadlay, Jonathan B Spencer, Tom L Blundell
Mar 12, 2021
The thioesterase FlK from the fluoroacetate-producing Streptomyces cattleya catalyzes the hydrolysis of fluoroacetyl-coenzyme A. This provides an effective self-defense mechanism, preventing any fluoroacetyl-coenzyme A formed...
Acetyl Coenzyme A Biocatalysis Catalytic Domain Crystallography X-Ray Hydrophobic and Hydrophilic Interactions Models Molecular Mutagenesis Site-Directed Mutant Proteins Mutation Protein Structure Quaternary Protein Structure Secondary Streptomyces Substrate Specificity Thiolester Hydrolases Threonine
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